[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569819":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":49,"locations":59,"responsibleParty":86,"collaborators":89,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":54,"eligibilityCriteria":98,"healthyVolunteers":94,"sex":99,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":54,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":62,"whyStopped":54,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"King Abdulaziz University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Arresting Treatment 1","ACTIVE_COMPARATOR","Management of dental caries in children between the ages of 4 and 10 by arresting the lesion using standard Treatment for caries arrest, which is silver diamine fluoride %38",[13],"Drug: Silver diamine Fluoride 38%",{"label":15,"type":16,"description":17,"interventionNames":18},"Arresting Treatment 2","EXPERIMENTAL","Management of dental caries n children between the ages of 4 and 10 by arresting the lesion using an alternative Treatment by using the combination of Silver diamine fluoride 38% + potassium iodide (SDF+KI), Both products reported as materials with an anti-microbial effect",[19],"Drug: Silver diamine fluoride- potassium iodide",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Silver diamine Fluoride 38%","Intervention is the application of Silver diamine fluoride 38% to children Group in arm 1 (Arm 1): children will receive Silver diamine fluoride 38% application for 1 min to arrest primary teeth\n\nSDF: (Silver diamine fluoride 38% is a material used for arresting caries lesions in primary and permanent teeth)\n\n\\- SDF Product generic name and information (E-SDF: it is a 1-step Technique) - The 38% SDF solution comprised a blend of silver, fluoride, and ammonia at a total concentration of 38%.",[9],[27,28],"E-SDF","Silver diamine fluoride",{"type":22,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Silver diamine fluoride- potassium iodide","Intervention is the application of Silver diamine fluoride 38% + potassium iodide to children Group in arm 2 (Arm 2): children will receive Silver diamine fluoride 38% application for 1 min to arrest primary teeth, Followed by an second minute of potassium iodide solution application\n\n\\- SDF Product generic name and information (Riva-star: it is a 2-step Technique) 30-35% SDF solution (1st step) comprised a blend of silver, fluoride, and ammonia applied in combination with a second application of potassium iodide solution (2nd step)",[15],[34,35],"Silver diamine fluoride 38% + potassium iodide","Riva- star SDF",[37,41,44,46],{"name":38,"affiliation":39,"role":40},"Dr. Turki S Abujamel, BDS, MSc, PhD","Department of Medical Laboratory Science, King Abdulaziz University and KFMRC Deputy Director of Administrative and Financial Affairs.","STUDY_DIRECTOR",{"name":42,"affiliation":43,"role":40},"Prof. (Dr.) Abdullah S AlMushayt, BDS, MSc, PhD","Faculty of Dentistry, Department of Pediatric Dentistry, King Abdulaziz University Jeddah, Saudi Arabia",{"name":45,"affiliation":43,"role":40},"Nada O Bamashmous, BDS, MSc, DDENT",{"name":47,"affiliation":48,"role":40},"Shatha O Bamashmous, BDS, MSc, PhD","Department of Periodontology, KAU Faculty of Dentistry, Jeddah, Saudi Arabia",[50,56],{"name":51,"role":52,"phone":53,"phoneExt":54,"email":55},"Dr.Doaa Y Jamal, BDS, MSc, SBPD","CONTACT","(+966)-558887632",null,"Djamal0004@stu.kau.edu.sa",{"name":42,"role":52,"phone":57,"phoneExt":54,"email":58},"(+966)-507733313","aalmushayt@kau.edu.sa",[60],{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"University Dental hospital of King Abdulaziz University","RECRUITING","Jeddah","Mecca Region","80209","Saudi Arabia","SA",{"type":69,"coordinates":70},"Point",[71,72],39.18624,21.49012,{"lat":72,"lon":71},[75,79,82,85],{"name":76,"role":52,"phone":77,"phoneExt":54,"email":78},"Dr.Nada O Bamashmous ( Head of Pediatric Dentistry Department), BDS, MSc, DDENT","+ 966 506356401","nobamashmous@kau.edu.sa",{"name":80,"role":52,"phone":81,"phoneExt":54,"email":58},"Prof. (Dr.) Abdullah S AlMushayt (Postgraduate Programs Director), BDS, MSc, PhD","+‭00966507733313‬",{"name":83,"role":84,"phone":54,"phoneExt":54,"email":54},"Dr.Doaa Y Jamal (PhD candidate), BDS, MSc, SBPD","PRINCIPAL_INVESTIGATOR",{"name":38,"role":84,"phone":54,"phoneExt":54,"email":54},{"type":84,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":54,"oldOrganization":54},"Doaa Yasir Jamal","PhD candidate - Pediatric dental specialist",[90],{"name":91,"class":6},"King Fahd Medical Research Centre","100569819","phase-4-effect-of-silver-diamine-fluoride-application-on-oral-microbiome-of-healthy-pediatric-patient-100569819",false,"NCT06699199","Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient","Effect of Silver Diamine Fluoride Application on Oral Microbiome of Saudi Children: Randomized Clinical Trial in Jeddah City","Inclusion criteria\n\n* Healthy patients.\n* Patients within 4-10 years of age.\n* The presence of at least one deciduous tooth with a caries lesion that is directly accessible (cavitates)\n\nExclusion Criteria:\n\n* Presentation of irreversible pulpititis or necrosis• The extensive lesion was restored.\n* The surface of the lesion was hard and smooth.\n* Children with inherited or systemic conditions.\n* Children with a substantial medication history or those who have taken antibiotics within the previous three months.\n* Children who have undergone topical fluoride treatment within the previous 2 weeks.","ALL","4 Years","12 Years",{"count":103,"type":104},50,"ESTIMATED","INTERVENTIONAL",[107],"PHASE4","This clinical trial aims to learn more about the working mechanism of an antimicrobial agent used to manage dental caries, especially in young, uncooperative children. It will also provide a deeper insight into different products of the same agent and its effectiveness in Arresting dental caries.\n\nThe main questions it aims to answer are:\n\nWhat is the clinical impact of silver diamine fluoride application in caries-active children? What is the antimicrobial effect of silver diamine fluoride in oral microbial inhabitants? Researchers will compare silver diamine fluoride (SDF)only and silver diamine fluoride+ potassium iodide(SDF+KI) to see which materials substantially affect on dental caries and oral microbial inhabitants\n\nParticipants\u002FParent will:\n\nThe parent will fill out a comprehensive data sheet for the child (childhood and current dental and medical history) Visit the dental clinic to Receive one of 2 (SDF or SDF+KI) treatment applications once Visit the clinic a 2nd time for a 2-4 week Treatment Follow-up Go through the sample collection process twice( pre- and 2-4 weeks post- Treatment) Sample collection including (Saliva- Biofilm and caries tissue sample)",[110],"Dental Caries",[112,113,114,115,116,117],"Dental Management","Oral Microbiome","Caries Arrest","SDF","Silver diamine fluoride 38%","Potassium iodide","2025-03-03",{"date":120,"type":121},"2025-03-06","ACTUAL",{"date":123,"type":121},"2023-11-01",{"date":125,"type":104},"2025-06-30",{"name":5,"class":6},1]