[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642879":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":37,"locations":26,"responsibleParty":45,"collaborators":47,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":26,"enrollmentInfo":61,"targetDuration":26,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":73,"whyStopped":26,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":26},{"fullName":5,"class":6},"University of Zurich","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"SOT followed by Sham intervention","ACTIVE_COMPARATOR","5L \u002Fmin supplemental oxygen therapy through a nasal canula will be administered to the participants. The intervention will start 5 minutes before the neurocognitive assessments and will be administered throughout the assessment. After \\>4 hours of washout, the participants will repeat the neurocognitive assessments with 5 L\u002Fmin sham intervention (room air).",[13,14],"Drug: Supplemental oxygen therapy","Other: Sham intervention",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham intervention followed by SOT","SHAM_COMPARATOR","5L \u002Fmin sham intervention (room air) through a nasal canula will be administered to the participants. The intervention will start 5 minutes before the neurocognitive assessments and will be administered throughout the assessment. After \\>4 hours of washout, the participants will repeat the neurocognitive assessments with 5 L\u002Fmin supplemental oxygen therapy.",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Supplemental oxygen therapy","5 L\u002Fmin supplemental oxygen therapy administered through nasal canula.",[9,16],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham intervention","5 L\u002Fmin sham intervention administered through nasal canula.",[9,16],[32,35],{"name":33,"affiliation":5,"role":34},"Michael Furian","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Edith M Schneider, Dr.",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":26,"email":42},"Michael Furian, Prof. Dr.","CONTACT","+41794037586","michael.furian@usz.ch",{"name":36,"role":40,"phone":26,"phoneExt":26,"email":44},"edith.schneidergasser@usz.ch",{"type":46,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[48],{"name":49,"class":50},"National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov","OTHER_GOV","100642879","phase-4-effect-of-supplemental-oxygen-therapy-on-neurocognitive-performance-in-healthy-highlanders-100642879",false,"NCT07651917","Effect of Supplemental Oxygen Therapy on Neurocognitive Performance in Healthy Highlanders","SPIRIT_1","Inclusion Criteria:\n\n* Signed written consent\n* Age \\>18\n* Kyrgyz ethnicity\n* Born, raised and living at approximately 2500 m\n* Native or fluent in Russian language\n\nExclusion Criteria:\n\n* Severe disease such as unstable hypertension, coronary heart disease, pulmonary diseases, others.\n* Regular use of medication that interfere with sleep or breathing such as benzodiazepines, opioids, acetazolamide\n* Heavy smoking of \\>20 cigarettes per day\n* Not able to read or adhere to the study protocol",true,"ALL","18 Years",{"count":62,"type":63},50,"ESTIMATED","INTERVENTIONAL",[66],"PHASE4","Exposure to high altitudes, defined as locations above 2500 m, has been shown to cause cognitive alternations due to reduced blood oxygenation (SpO2). However, it remains to be determined whether cognitive changes are present in highlanders living at moderate altitudes (2500 m) and whether cognitive alterations are reversible with supplemental oxygen therapy (SOT).",[69],"Neurocognition",[71,72,23],"Hypoxia","Altitude","NOT_YET_RECRUITING","2026-06-10",{"date":76,"type":77},"2026-06-16","ACTUAL",{"date":79,"type":63},"2026-06-18",{"date":81,"type":63},"2026-07-31",{"name":5,"class":6}]