[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543687":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":213,"collaborators":26,"id":217,"slug":218,"hasResults":219,"nctId":220,"briefTitle":221,"officialTitle":221,"acronym":26,"eligibilityCriteria":222,"healthyVolunteers":219,"sex":223,"minAge":224,"maxAge":26,"enrollmentInfo":225,"targetDuration":26,"studyType":228,"phases":229,"briefSummary":231,"conditions":232,"keywords":26,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":243},{"fullName":5,"class":6},"China Medical University, China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control: 80% Oxygen","PLACEBO_COMPARATOR","Before anesthesia induction, the participants inhaled 100% oxygen through the mask for 3 minutes. After successful anesthesia induction, the fraction of inspired oxygen (FiO2) will be adjusted to 80%, and the total gas flow rate will be set at 2L\u002Fminute. All patients will receive treatment through the lung-protective ventilation strategy. The respiratory parameters are VT: 6-8mL\u002Fkg, positive end-expiratory pressure (PEEP), 6-8 cmH2O; RR: 1:2, and respiratory rate will be adjusted by maintaining a partial pressure of carbon dioxide at 35-45 mmHg. Manual lung recruitment maneuvers will be performed after tracheal intubation and before tracheal extubation. Blood will be collected for blood gas analysis within 48 hours after surgery.",[13],"Drug: 80% Oxygen",{"label":15,"type":16,"description":17,"interventionNames":18},"Experimental: 40% Oxygen","EXPERIMENTAL","Before anesthesia induction, the participants inhaled 100% oxygen through the mask for 3 minutes. After successful anesthesia induction, FiO2 will be adjusted to 40%, and the total gas flow rate will be set at 2L\u002Fminute. All patients will receive treatment through the lung-protective ventilation strategy. The respiratory parameters are VT: 6-8mL\u002Fkg, positive end-expiratory pressure (PEEP), 6-8 cmH2O; RR: 1:2, and respiratory rate will be adjusted by maintaining a partial pressure of carbon dioxide at 35-45 mmHg. Manual lung recruitment maneuvers will be performed after tracheal intubation and before tracheal extubation. However, when intraoperative oxygen saturation is less than 94%, the manual lung recruitment maneuver will also be performed. Patients should transfer to 80% Oxygen group if intraoperative oxygen saturation less than 85%.Blood will be collected for blood gas analysis within 48 hours after surgery.",[19],"Drug: 40% Oxygen",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","80% Oxygen","After successful anesthesia induction, the fraction of inspired oxygen (FiO2) will be adjusted to 80%, and the total gas flow rate will be set at 2L\u002Fminute.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"40% Oxygen","After successful anesthesia induction, the fraction of inspired oxygen (FiO2) will be adjusted to 40%, and the total gas flow rate will be set at 2L\u002Fminute.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Tianhao Zhang, M.D.","CONTACT","+862483283100","zhth774176947@163.com",{"name":38,"role":34,"phone":35,"phoneExt":26,"email":39},"Yang An, 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Hospital",{"type":50,"coordinates":126},[117,118],{"lat":118,"lon":117},[129],{"name":130,"role":34,"phone":26,"phoneExt":26,"email":26},"Fei Han",{"facility":132,"status":43,"city":133,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"First Medical University and Shandong Provincial Qianfoshan Hospital","Jinan",{"type":50,"coordinates":135},[136,137],116.99722,36.66833,{"lat":137,"lon":136},[140],{"name":141,"role":34,"phone":26,"phoneExt":26,"email":26},"Jianbo Wu",{"facility":143,"status":43,"city":144,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"First Affiliated Hospital of Kunming Medical University","Kunming",{"type":50,"coordinates":146},[147,148],102.71833,25.03889,{"lat":148,"lon":147},[151],{"name":152,"role":34,"phone":26,"phoneExt":26,"email":26},"Jianlin Shao",{"facility":154,"status":43,"city":155,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"Affiliated Hospital of Qingdao University","Qingdao",{"type":50,"coordinates":157},[158,159],120.38042,36.06488,{"lat":159,"lon":158},[162],{"name":163,"role":34,"phone":26,"phoneExt":26,"email":26},"Wei Feng",{"facility":165,"status":43,"city":44,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":166,"geoPoint":168,"contacts":169},"Liaoning Cancer Hospital and Institute",{"type":50,"coordinates":167},[52,53],{"lat":53,"lon":52},[170],{"name":171,"role":34,"phone":26,"phoneExt":26,"email":26},"Zeqing Huang",{"facility":173,"status":43,"city":174,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":175,"geoPoint":179,"contacts":180},"Shenzhen People's Hospita","Shenzhen",{"type":50,"coordinates":176},[177,178],114.0683,22.54554,{"lat":178,"lon":177},[181],{"name":182,"role":34,"phone":26,"phoneExt":26,"email":26},"Chaoran Wu",{"facility":184,"status":43,"city":185,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":186,"geoPoint":190,"contacts":191},"First Hospital of Hebei Medical University","Shijia Zhuang",{"type":50,"coordinates":187},[188,189],109.84894,34.17775,{"lat":189,"lon":188},[192],{"name":193,"role":34,"phone":26,"phoneExt":26,"email":26},"Li Wang",{"facility":195,"status":43,"city":185,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":196,"geoPoint":198,"contacts":199},"Second Hospital of Hebei Medical University",{"type":50,"coordinates":197},[188,189],{"lat":189,"lon":188},[200],{"name":201,"role":34,"phone":26,"phoneExt":26,"email":26},"Lining Huang",{"facility":203,"status":43,"city":204,"state":26,"zip":26,"country":47,"countryCode":48,"cosmosGeoPoint":205,"geoPoint":209,"contacts":210},"YANBIAN University Hospital（Yanbian Hospital）","Yanbian",{"type":50,"coordinates":206},[207,208],107.6096,36.41442,{"lat":208,"lon":207},[211],{"name":212,"role":34,"phone":26,"phoneExt":26,"email":26},"Yongshan Nan",{"type":214,"investigatorFullName":215,"investigatorTitle":216,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Wenfei Tan","Professor,Chairman","100543687","phase-4-effects-of-different-inhaled-oxygen-concentrations-on-lung-function-in-older-patients-after-laparoscopic-gastrointestinal-surgery-under-general-anesthesia-100543687",false,"NCT06359106","Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia","Inclusion Criteria:\n\n* Age not less than 65 years\n* American Society of Anesthesiologists grades I-III\n* No history of drug allergies or abnormal anesthesia.\n* The duration of mechanical ventilation was expected to be more than 2 hours.\n* Laparoscopic Gastrointestinal Surgery\n* The preoperative oxygen saturation was not less than 94%.\n* The patients will be planned to extubate in the operating room.\n\nExclusion Criteria:\n\n* History of acute lung injury or acute respiratory distress syndrome (ARDS) within 3 months.\n* Cardiac function Class IV (New York Heart Association classification)\n* Chronic renal failure (renal cell filtration rate \\\u003C30 ml min-11.73\u002Fm2), severe liver disease\n* Patients with blurred consciousness and cognitive dysfunction\n* Severe coagulation dysfunction.\n* Without preoperative oxygen inhalation, blood oxygen level \\\u003C94%, and severe pulmonary dysfunction\n* Patients with endotracheal tubes were admitted to the intensive care unit (ICU) after surgery.\n* Body mass index (BMI) \\>30kg\u002Fm2\n* Inability to complete the study","ALL","65 Years",{"count":226,"type":227},1176,"ESTIMATED","INTERVENTIONAL",[230],"PHASE4","This was a multicenter, prospective, parallel-grouping, randomized controlled clinical study comparing low FiO2 (40%) and high FiO2 (80%) levels in older patients undergoing laparoscopic gastrointestinal surgery.",[233],"Oxygenation Index","2026-01-23",{"date":236,"type":237},"2026-01-26","ACTUAL",{"date":239,"type":237},"2024-07-02",{"date":241,"type":227},"2026-06-30",{"name":5,"class":6},16]