[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580704":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":176,"collaborators":180,"id":184,"slug":185,"hasResults":186,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":186,"sex":192,"minAge":193,"maxAge":25,"enrollmentInfo":194,"targetDuration":25,"studyType":197,"phases":198,"briefSummary":200,"conditions":201,"keywords":208,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":229},{"fullName":5,"class":6},"McMaster University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sex-matched","EXPERIMENTAL","Sex-matched red blood cell transfusion",[13],"Biological: Sex-matched red blood cell 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Science","24928","levoyjob@mcmaster.ca",[44,65,82,98,114,130,145,158],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Hamilton General Hospital","RECRUITING","Hamilton","Ontario","L8L 2X2","Canada","CA",{"type":53,"coordinates":54},"Point",[55,56],-79.84963,43.25011,{"lat":56,"lon":55},[59,64],{"name":60,"role":35,"phone":61,"phoneExt":62,"email":63},"Andrew Shih, Doctor of Medicine","905-527-0271","46140","shiha@mcmaster.ca",{"name":60,"role":32,"phone":25,"phoneExt":25,"email":25},{"facility":66,"status":67,"city":68,"state":48,"zip":69,"country":50,"countryCode":51,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Kingston Health Sciences Centre","NOT_YET_RECRUITING","Kingston","K7L 2V7",{"type":53,"coordinates":71},[72,73],-76.48098,44.22976,{"lat":73,"lon":72},[76,81],{"name":77,"role":35,"phone":78,"phoneExt":79,"email":80},"Jeannie Callum, Doctor of 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Medicine","1-416-340-4800","8116","Jacob.Pendergrast@uhn.ca",{"name":171,"role":35,"phone":172,"phoneExt":168,"email":173},"Nadia Gabarin, Doctor of Medicine","416-340-4800","nadia.gabarin@uhn.ca",{"name":166,"role":32,"phone":25,"phoneExt":25,"email":25},{"name":171,"role":32,"phone":25,"phoneExt":25,"email":25},{"type":177,"investigatorFullName":178,"investigatorTitle":179,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Michelle Zeller","Associate Professor",[181],{"name":182,"class":183},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV","100580704","phase-4-effects-of-donor-recipient-sex-matched-blood-transfusion-on-patient-outcomes-100580704",false,"NCT06840756","Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes","Effects of Donor-recipient Sex-matched Versus Sex-mismatched Red Blood Cell Transfusion on Outcomes in Critically Ill Adult Patients","SexMATTERS RCT","Inclusion Criteria:\n\n* Adults (age ≥18);\n* Admission to a participating ICU;\n* Requiring RBC transfusion.\n\nExclusion Criteria:\n\n* Requirement for a specialized RBC product or unit not readily available in inventory (e.g., rare blood type, washed RBCs, complex RBC antibodies, etc.);\n* Massively bleeding patient (i.e., ≥4 units of blood ordered at one time, or Massive Hemorrhage Protocol initiated, or an urgent blood request made);\n* Sex unknown or sex other than male or female (i.e. intersex);\n* Do not have a valid Ontario Health Insurance Plan (OHIP) health card number.","ALL","18 Years",{"count":195,"type":196},11082,"ESTIMATED","INTERVENTIONAL",[199],"PHASE4","Red blood cell (RBC) transfusions are selected based upon matching donor and recipient blood group: donor and recipient sex are not considered when selecting blood for transfusion. Hence, transfused patients can currently receive sex-matched and\u002For unmatched RBCs when transfusions are given. Sex-matched stem cell transplants, and some solid organ transplants, have shown that sex-matching donor to recipient improves patient outcomes. Recent exploratory studies have also suggested that patient outcomes could be improved by sex-matching for RBC transfusion. There is emerging evidence of underlying biologic mechanism(s) to support these observations. This study is designed as a randomized controlled trial and will explore the impact on patients who receive RBC transfusions from donors of the same sex (\"sex-matched\") compared with donors of the opposite sex (\"sex-mismatched\").\n\nThe trial will study adult patients admitted to the Intensive Care Unit who require an RBC transfusion. Patients will be assigned (through a process called randomization) to receive sex-matched RBCs or sex-mismatched RBCs to determine if there is a difference in mortality between those receiving matched versus mismatched RBCs. The results of this trial could have direct implications on resources, blood inventory, and RBC transfusion ordering practices.",[202,203,204,205,206,207],"Red Blood Cell Transfusions","Sex Differences","Health Services","Critically Ill Intensive Care Unit Patients","Hematology","Cardiovascular",[209,210,211,212,213,214,215,216,217,218,219],"transfusions","red blood cell transfusions","sex-matched","sex-mismatched","intensive care unit","ICU","cardiovascular","circulatory","hematology","mortality","blood donor characteristics","2026-03-10",{"date":222,"type":223},"2026-03-12","ACTUAL",{"date":225,"type":223},"2025-09-11",{"date":227,"type":196},"2029-03-31",{"name":178,"class":6},8]