[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633781":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":39,"centralContacts":43,"locations":48,"responsibleParty":62,"collaborators":31,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":31,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":31,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":92,"whyStopped":31,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Izmir Katip Celebi University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Oral flurbiprofen (0.25%) spray group","ACTIVE_COMPARATOR","This group will receive one puff of oral flurbiprofen (0.25%) spray (for pain palliation) at 5 hours post-operatively",[13],"Drug: Flurbiprofen",{"label":15,"type":10,"description":16,"interventionNames":17},"Ice cream group","This group will receive 105 ml of frozen ice cream at 5 hours post-operatively",[18],"Dietary Supplement: Food Effect cohort",{"label":20,"type":21,"description":22,"interventionNames":23},"Placebo group","PLACEBO_COMPARATOR","This group will receive one puff of spray prepared with drinking water at 5 hours post-operatively as a placebo.",[24],"Drug: Placebo Control",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Flurbiprofen","This group will receive one puff of oral flurbiprofen (0.25%) spray (for pain palliation) at 5 hours post-operatively.",[9],null,{"type":33,"name":34,"description":16,"armGroupLabels":35,"otherNames":31},"DIETARY_SUPPLEMENT","Food Effect cohort",[15],{"type":27,"name":37,"description":22,"armGroupLabels":38,"otherNames":31},"Placebo Control",[20],[40],{"name":41,"affiliation":5,"role":42},"Serkan KARAISLI, Asc.Professor, MD, FEBS (End.)","PRINCIPAL_INVESTIGATOR",[44],{"name":41,"role":45,"phone":46,"phoneExt":31,"email":47},"CONTACT","00 90 555 373 8550","skaraisli@gmail.com",[49],{"facility":5,"status":31,"city":50,"state":31,"zip":51,"country":52,"countryCode":31,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Izmir","35620","Turkey (Türkiye)",{"type":54,"coordinates":55},"Point",[56,57],27.13838,38.41273,{"lat":57,"lon":56},[60],{"name":41,"role":45,"phone":61,"phoneExt":31,"email":47},"90 555 373 8550",{"type":42,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Serkan Karaisli","Associate Professor, MD, F.E.B.S (End.)","100633781","phase-4-effects-of-flurbiprofen-spray-and-ice-cream-for-pain-and-voice-outcomes-after-thyroidectomy-100633781",false,"NCT07531147","Effects of Flurbiprofen Spray and Ice Cream for Pain and Voice Outcomes After Thyroidectomy","Comparison of the Effects of Postoperative Oral Flurbiprofen (0.25%) Spray and Ice Cream on Analgesia and Voice Quality in Patients Undergoing Thyroidectomy","Inclusion Criteria:\n\n* No history of neck surgery\n* Age between 18-85 years\n* Undergoing thyroidectomy\n* Agreeing to participate in the study\n* Operation duration between 60-120 minutes\n\nExclusion Criteria:\n\n* History of neck surgery\n* History of radiotherapy to the head and neck region\n* Pre-operative or post-operative vocal cord paralysis\n* Pre-operative phonetic disorder\n* Pre-operative laryngeal pathology\n* Being under 18 years of age\n* Refusal to participate in the study\n* Smoking\n* Flurbiprofen allergy\n* Lactose intolerance","ALL","18 Years","85 Years",{"count":76,"type":77},100,"ESTIMATED","INTERVENTIONAL",[80],"PHASE4","Researchers will compare oral flurbiprofen (%0.25) spray and ice cream to a placebo (a look-alike substance that contains no drug) to see if oral flurbiprofen (%0.25) spray and ice cream works to effect post-thyroidectomy throat pain and voice quality.\n\nParticipants will:\n\n* Receive 1 puff of oral flurbiprofen (0.25%) spray or 105 ml of ice cream or 1 puff of oral spray prepared with drinking water (placebo) at 5 hours postoperatively according to randomization result\n* Undergo voice analysis using Praat voice analysis (University of Amsterdam) at 6 hours postoperatively\n* Undergo a visual analog scale for analgesia status at 6 hours postoperatively",[83,84,85],"Thyroidectomy","Sore Throat","Voice Quality",[87,88,89,90,91],"thyroidectomy","sore throat","voice quality","flurbiprofen","ice cream","NOT_YET_RECRUITING","2026-04-11",{"date":95,"type":96},"2026-04-15","ACTUAL",{"date":98,"type":77},"2026-04",{"date":100,"type":77},"2026-09",{"name":5,"class":6},1]