[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597938":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":45,"locations":55,"responsibleParty":67,"collaborators":31,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":31,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":97,"whyStopped":31,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Yuzuncu Yil University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo Group","PLACEBO_COMPARATOR","Patients will receive 20 mL of normal saline administered intraarticularly at the end of surgery.",[13],"Drug: Saline",{"label":15,"type":16,"description":17,"interventionNames":18},"Tramadol Group","EXPERIMENTAL","Patients will receive 100 mg tramadol diluted with saline to a total volume of 20 mL, administered intraarticularly at the end of surgery.",[19],"Drug: Tramadol",{"label":21,"type":16,"description":22,"interventionNames":23},"Tramadol + Dexamethasone Group","Patients will receive 100 mg tramadol combined with 8 mg dexamethasone diluted with saline to a total volume of 20 mL, administered intraarticularly at the end of surgery.",[24],"Drug: Tramadol + Dexamethasone",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Saline","20 mL of normal saline administered intraarticularly at the end of surgery.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Tramadol","Tramadol 100 mg diluted with saline to a total volume of 20 mL, administered intraarticularly at the end of surgery.",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Tramadol + Dexamethasone","Tramadol 100 mg combined with dexamethasone 8 mg diluted with saline to a total volume of 20 mL, administered intraarticularly at the end of surgery.",[21],[41],{"name":42,"affiliation":43,"role":44},"Şükran Sevimli, PhD","Van Yuzuncu Yil University Ethics","STUDY_CHAIR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":31,"email":50},"Arzu Esen Tekeli, MD","CONTACT","+905053756375","esentekeli190807@hotmail.com",{"name":52,"role":48,"phone":53,"phoneExt":31,"email":54},"Doğukan Çatulay, MD","05556880881","dctly9292@gmail.com",[56],{"facility":57,"status":31,"city":58,"state":31,"zip":59,"country":60,"countryCode":31,"cosmosGeoPoint":61,"geoPoint":66,"contacts":31},"Van Yuzuncu Yil University School of Medicine Department of Anesthesiology and Reanimation","Van","65100","Turkey (Türkiye)",{"type":62,"coordinates":63},"Point",[64,65],43.38323,38.49457,{"lat":65,"lon":64},{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"SPONSOR_INVESTIGATOR","Arzu Esen Tekeli","Associate Professor of Anesthesiology","100597938","phase-4-effects-of-intraarticular-tramadol-and-tramadol-dexamethasone-on-postoperative-pain-after-knee-arthroscopy-100597938",false,"NCT07064993","Effects of Intraarticular Tramadol and Tramadol-Dexamethasone on Postoperative Pain After Knee Arthroscopy","A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating the Effects of Intraarticular Tramadol and Tramadol Plus Dexamethasone on Postoperative Pain After Knee Arthroscopy","KATD-PAIN","Inclusion Criteria:\n\nPatients aged 18-65 years ASA physical status I-II Scheduled for elective knee arthroscopy under general anesthesia Only minor arthroscopic procedures such as partial meniscectomy will be included Ability to provide informed consent\n\nExclusion Criteria:\n\nAllergy or contraindication to tramadol or dexamethasone Chronic opioid use or chronic pain conditions History of psychiatric or neurological disorders that may affect pain perception Severe hepatic or renal impairment Pregnancy or breastfeeding Infection at the injection site Bleeding diathesis Refusal to participate Major reconstructive knee surgeries (e.g., anterior cruciate ligament reconstruction)","ALL","18 Years","65 Years",{"count":83,"type":84},135,"ESTIMATED","INTERVENTIONAL",[87],"PHASE4","Patients scheduled for elective knee arthroscopy under general anesthesia will be randomly assigned into three groups in a 1:1:1 ratio: placebo (saline), tramadol, and tramadol plus dexamethasone. At the end of surgery, after aspiration of the irrigation fluid, the study solution will be administered intraarticularly in a standardized volume.\n\nThe primary outcome is the area under the curve (AUC) of VAS scores measured at 0, 2, 6, 12, and 24 hours postoperatively (VAS AUC 0-24h). Secondary outcomes include time to first analgesic requirement, total analgesic consumption within 24 hours, and the incidence of adverse effects such as nausea, vomiting, itching, and shivering.\n\nThis study aims to determine whether intraarticular tramadol provides effective postoperative analgesia and whether the addition of dexamethasone enhances this analgesic effect.",[90,91],"Knee Arthroscopy","Postoperative Pain",[90,91,93,33,94,95,96],"Intraarticular Injection","Dexamethasone","Analgesia","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-05-11",{"date":100,"type":101},"2026-05-14","ACTUAL",{"date":103,"type":84},"2026-07-15",{"date":105,"type":84},"2027-04-30",{"name":69,"class":6},1]