[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100488112":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":26,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":26,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Qianfoshan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental:Esmolol","EXPERIMENTAL","The treatment group was given esmolol 0.5mg\u002Fkg load, 10μg \u002Fkg\u002Fmin continuous pump; Patient-controlled analgesia pump (sufentanil 2 μg\u002Fkg, 2 mL\u002Fh, for 48h) was used as the postoperative analgesia regimen in the two groups. If the VAS score was \\>3, analgesic adjuvant drugs were given intravenously and recorded. If repeated treatment is ineffective, the study will be excluded.",[13],"Drug: Esmolol",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Comparator:normal saline(0.9%)","PLACEBO_COMPARATOR","The control group received the same volume of 0.9% normal saline, which was continuously pumped until the end of the operation before extubation.Patient-controlled analgesia pump (sufentanil 2 μg\u002Fkg, 2 mL\u002Fh, for 48h) was used as the postoperative analgesia regimen in the two groups. If the VAS score was \\>3, analgesic adjuvant drugs were given intravenously and recorded. If repeated treatment is ineffective, the study will be excluded.",[19],"Drug: Placebo Comparator: Placebo Comparator:normal saline(0.9%)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Esmolol","The treatment group was given Esmolol 0.5mg\u002Fkg load and 10μg \u002Fkg\u002Fmin continuous pump",[9],null,{"type":22,"name":28,"description":17,"armGroupLabels":29,"otherNames":26},"Placebo Comparator: Placebo Comparator:normal saline(0.9%)",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"yongtao Sun, PH.D","CONTACT","18660795201","sunyongtao1979@163.com",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University","RECRUITING","Jinan","Shandong","China","CN",{"type":45,"coordinates":46},"Point",[47,48],116.99722,36.66833,{"lat":48,"lon":47},[51],{"name":52,"role":33,"phone":34,"phoneExt":26,"email":35},"Sun Y tao, pH.D",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Yongtao Sun","professor","100488112","phase-4-effects-of-low-dose-esmolol-on-myocardial-injury-after-non-cardiac-surgery-in-elderly-frail-patients-100488112",false,"NCT05635877","Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients","Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients:A Multicenter, Prospective, Double-blind, Randomized Controlled Study","Inclusion Criteria:\n\n1. Age ≥ 65 years;\n2. ASA: ⅰ-ⅳ;\n3. Modified frailty index (mFI) ≥ 0.21;\n4. Patients undergoing non-cardiac surgery.\n\nExclusion Criteria:\n\n1. Refuse to participate;\n2. Expected hospital stay \\\u003C3 days;\n3. Preoperative β-blocker therapy;\n4. History of myocardial infarction or coronary artery disease;\n5. Preoperative bradycardia (heart rate \\[HR\\] \\\u003C 50 bpm) or arrhythmia;\n6. Significant cardiac insufficiency (i.e., pulmonary artery pressure \\>18 mm Hg, cardiac index ≤ 2.2 L\u002Fmin\u002Fm 2);\n7. Severe valvular heart disease;\n8. Severe lung disease (e.g. asthma or chronic obstructive pulmonary disease);\n9. Patients with perioperative troponin elevation due to nonischemic causes (e.g., sepsis, pulmonary embolism, arrhythmia);\n10. The same patient can only be included once, regardless of whether the reason for the second operation is related to the first cause.\n\n    \\-","ALL","65 Years","90 Years",{"count":68,"type":69},2000,"ESTIMATED","INTERVENTIONAL",[72],"PHASE4","This topic will focus on the following questions:\n\n1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the predictive factors of myocardial injury after non-cardiac surgery （MINS） in elderly frail patients before operation.\n2. Part Two: To explore the effect of low-dose esmolol on myocardial injury after non-cardiac surgery in frail elderly patients.",[75,23,76],"Frailty","Myocardial Injury",[78],"myocardial injury after non-cardiac surgery, MINS","2023-03-27",{"date":81,"type":82},"2023-03-29","ACTUAL",{"date":84,"type":82},"2023-02-07",{"date":86,"type":69},"2026-12-30",{"name":55,"class":6},1]