[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600799":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":53,"collaborators":11,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":11,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":11,"maxAge":11,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":38,"whyStopped":11,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Badr University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"adapalene gel 0.1% once daily at bedtime","ACTIVE_COMPARATOR",null,[13],"Drug: use of adapalene gel 0.1% once daily at bedtime",{"label":15,"type":16,"description":11,"interventionNames":17},"adapalene gel 0.1% once daily at bedtime and hyaluronic acid","EXPERIMENTAL",[18],"Drug: use of adapalene gel 0.1% and hyaluronic acid at bedtime",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","use of adapalene gel 0.1% and hyaluronic acid at bedtime","in this intervention a combination of adapalene gel 0.1% and hyaluronic acid will be used",[15],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"use of adapalene gel 0.1% once daily at bedtime","in this intervention involves the use of adapalene gel 0.1% once daily only topically at bedtime",[9],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Hebatallah Moustafa, PhD","CONTACT","01001652500","hebatallah.ahmed@buc.edu.eg",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Badr university in Cairo","RECRUITING","Cairo","Cairo Governorate","11829","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],31.24967,30.06263,{"lat":48,"lon":47},[51],{"name":52,"role":32,"phone":33,"phoneExt":11,"email":34},"Hebatallah Moustafa",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Hebatallah Ahmed Mohamed Moustafa","Assistant professor in the clinical pharmacy and pharmacy practice department","100600799","phase-4-efficacy-and-safety-of-adapalene-gel-and-hyaluronic-acid-versus-adapalene-gel-alone-in-mild-to-moderate-acne-vulgaris-100600799",false,"NCT07102186","Efficacy and Safety of Adapalene Gel and Hyaluronic Acid Versus Adapalene Gel Alone in Mild to Moderate Acne Vulgaris","Comparing the Efficacy and Safety of Adapalene Gel and Hyaluronic Acid Versus Adapalene Gel Alone in Mild to Moderate Acne Vulgaris: An Open-label Randomized Controlled Trial.","Inclusion Criteria:\n\n* Patients with mild to moderate acne vulgaris who have not used topical retinoids or systemic acne treatments within the past 3 months will be included.\n\nExclusion Criteria:\n\n* patients with severe acne, nodulocystic acne, secondary infections, known hypersensitivity to adapalene or hyaluronic acid, pregnant, or lactating individuals.","ALL",{"count":66,"type":67},120,"ESTIMATED","INTERVENTIONAL",[70],"PHASE4","Acne vulgaris affects around 85% of adolescents and young adults. Adapalene, a topical retinoid, is a common treatment but often causes irritation, leading to poor adherence. Hyaluronic acid (HA), known for its hydrating and anti-inflammatory properties, may help reduce these side effects.\n\nThis prospective, open-label, randomized controlled trial compares adapalene 0.1% gel combined with HA serum versus adapalene alone over 8 weeks in patients with mild to moderate acne. Key outcomes include acne lesion reduction, incidence and severity of side effects (erythema, dryness, scaling, stinging\u002Fburning, pruritus), and skin hydration assessed through the skin turgor test. Acne severity will be measured using the Acne Severity Index (ASI) and Investigator's Global Assessment (IGA) scale.\n\nThe study anticipates better efficacy, reduced irritation, and improved skin hydration with the combination therapy. Ethical approval was obtained, and informed consent will be secured from all participants.",[73],"Acne Vulgaris",[75,76,77,78],"acne vulgaris","adapalene","Hyaluronic acid","Topical Retinoids","2025-07-28",{"date":81,"type":82},"2025-08-03","ACTUAL",{"date":84,"type":82},"2025-07-21",{"date":86,"type":67},"2025-10-21",{"name":5,"class":6},1]