[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100487402":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":42,"centralContacts":42,"locations":43,"responsibleParty":64,"collaborators":42,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":42,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":42,"enrollmentInfo":77,"targetDuration":42,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":46,"whyStopped":42,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Endeavor Health","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Azelastine and Mometasone Nasal Spray","ACTIVE_COMPARATOR","The study intervention will be saline irrigation (240 mL) followed by azelastine spray (137 mcg\u002Fspray) and mometasone spray (50 mcg\u002Fspray). Participants will have to dissolve the salt packet in a 240 mL sinus rinse bottle to create the saline solution. All participants will be instructed to perform the following twice a day: irrigation of right and left nasal cavity with half of the saline solution for each side followed by 2 sprays per nostril of both of the nasal sprays.",[13],"Drug: Azelastine (137 mcg\u002Fspray) Nasal Spray and Mometasone (50 mcg\u002Fspray) Nasal Spray",{"label":15,"type":16,"description":17,"interventionNames":18},"Mometasone Nasal Irrigation","EXPERIMENTAL","The study intervention will be mometasone (1 mg\u002Fcapsule). Participants will be required to dissolve the contents of the capsule into a 240 mL sinus rinse bottle along with the salt packet to create the rinse solution. All participants will be instructed to perform the following twice a day: irrigation of right and left nasal cavity with half of the rinse solution for each side.",[19],"Drug: Mometasone Nasal Irrigation (1 mg capsule)",{"label":21,"type":16,"description":22,"interventionNames":23},"Azelastine and Mometasone Nasal Irrigation","The study intervention will be azelastine (1mg) and mometasone (1 mg). The azelastine and mometasone will be provided in one capsule identical to the mometasone capsule. Participants will be required to dissolve the contents of the capsule into a 240 mL sinus rinse bottle along with the salt packet to create the rinse solution. All participants will be instructed to perform the following twice a day: irrigation of right and left nasal cavity with half of the rinse solution for each side.",[24],"Drug: Mometasone (1 mg) and Azelastine (1 mg) Nasal Irrigation",[26,33,38],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Azelastine (137 mcg\u002Fspray) Nasal Spray and Mometasone (50 mcg\u002Fspray) Nasal Spray","Participants will follow this medication regimen for 6 months.",[9],[32],"Astelin, Nasonex",{"type":27,"name":34,"description":29,"armGroupLabels":35,"otherNames":36},"Mometasone Nasal Irrigation (1 mg capsule)",[15],[37],"Nasonex",{"type":27,"name":39,"description":29,"armGroupLabels":40,"otherNames":41},"Mometasone (1 mg) and Azelastine (1 mg) Nasal Irrigation",[21],[32],null,[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Northshore University HealthSystem","RECRUITING","Evanston","Illinois","60201","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-87.69006,42.04114,{"lat":56,"lon":55},[59],{"name":60,"role":61,"phone":62,"phoneExt":42,"email":63},"Auddie Sweis, MD","CONTACT","847-570-1700","asweis@northshore.org",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"PRINCIPAL_INVESTIGATOR","Auddie Sweis","Principal Investigator","100487402","phase-4-efficacy-of-azelastine-and-mometasone-irrigation-in-comparison-to-nasal-sprays-in-patients-with-chronic-rhinitis-100487402",false,"NCT05626621","Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis","Inclusion Criteria:\n\n* Adults 18 years and older seeking treatment for chronic rhinitis and willing to undergo six months of topical therapy.\n* Diagnosis of Chronic Rhinitis.\n\nExclusion Criteria:\n\n* The patient has diagnosis(es) other than chronic rhinitis that can account for his\u002Fher symptoms (septal deviation, nasal valve collapse, chronic sinusitis).\n* Use of oral antihistamines or oral steroids, unless patient undergoes a 4 week washout period.\n* Smokers (tobacco, marijuana, vaping, etc.).\n* Known or suspected pregnancy, or lactation.\n* Other medical conditions that the investigator believed would confound the study.\n* Allergy to study drugs.",true,"ALL","18 Years",{"count":78,"type":79},81,"ESTIMATED","INTERVENTIONAL",[82],"PHASE4","The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is:\n\nDo high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastine combined with nasal steroid mometasone as compared to the standard low pressure, low volume delivery mechanisms in nasal sprays?\n\nSubjects will complete six months of one of three medication regimens:\n\n1. Saline irrigation followed by azelastine spray and mometasone spray\n2. Mometasone saline irrigation\n3. Azelastine saline irrigation combined with mometasone saline irrigation.",[85],"Chronic Rhinitis",[87,88,89,90,91,92],"mometasone","azelastine","irrigation","topical therapy","nasal spray","chronic rhinitis","2023-07-25",{"date":95,"type":96},"2023-07-28","ACTUAL",{"date":98,"type":96},"2022-11-23",{"date":100,"type":79},"2026-08",{"name":5,"class":6},1]