[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600642":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":44,"responsibleParty":50,"collaborators":44,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":44,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":44,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":78,"whyStopped":44,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":44},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Topical coconut gel (50%)","EXPERIMENTAL","topical coconut gel (50%) four times per day (after every meal and before going to bed) for eight weeks",[13],"Other: Coconut oil",{"label":15,"type":16,"description":17,"interventionNames":18},"Topical corticosteroid","ACTIVE_COMPARATOR","topical corticosteroid (triamcinolone acetonide 0.1%) four times per day for eight weeks",[19],"Drug: Triamcinolone Acetonide",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Coconut oil","The composition per 100 g of virgin coconut oil 50% in oral mucoadhesive gel will be coconut oil (50 ml), tween 20 (surfactant-2.5 g) or span 60 (surfactant-2.5 g), Carbopol 940 (gelling agent-1 g), triethanolamine (viscous organic compound-0.2 g) and vanillin (0.001 g)",[9],[26],"coconut gel",{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","Triamcinolone Acetonide","topical corticosteroid",[15],[33],"kenalog in orabase",[35],{"name":36,"affiliation":37,"role":38},"Nevine H Kheir El Din, Professor","faculty of dentistry Ain Shams University","STUDY_DIRECTOR",[40,46],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Shahenda M Farid, Ass.lecturer","CONTACT","01110399350",null,"shahendamahmoud@dent.asu.edu.eg",{"name":47,"role":42,"phone":48,"phoneExt":44,"email":49},"Radwa M Ragheb, Professor","01005524754","radwa.ragheb@dent.asu.edu.eg",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"PRINCIPAL_INVESTIGATOR","Shahenda Mahmoud Farid Mahmoud","Assistant lecturer of oral medicine and periodontology department","100600642","phase-4-efficacy-of-coconut-gel-compared-to-corticosteroid-gel-in-the-management-of-oral-lichen-planus-100600642",false,"NCT07100145","Efficacy of Coconut Gel Compared to Corticosteroid Gel in the Management of Oral Lichen Planus","Efficacy of Coconut Gel Compared to Corticosteroid Gel in the Management of Oral Lichen Planus (A Randomized Controlled Clinical Trial With Biochemical Analysis)","Inclusion Criteria:\n\n* Clinically and histologically proven Bullous\u002Ferosive or atrophic forms of OLP.\n\nExclusion Criteria:\n\n* lichenoid lesions.\n* Presence of systemic conditions as; serious active or recurrent infections, malignancy, diabetes mellitus, hypertension, or significant heart, liver, or renal diseases.\n* Smoking.\n* Known hypersensitivity to the treatment drugs or any of the ingredients.\n* Pregnancy or breast-feeding.\n* History of previous treatments potentially effective on OLP such as antimalarial agents, retinoids, corticosteroids or immunosuppressive drugs in the last 2 weeks for topical medications, and 4 weeks for systemic medications prior to starting the study.\n* Loss of pliability or flexibility in the tissues involved by the oral lesions of lichen planus.\n* Histological signs of epithelial dysplasia or lichenoid lesions within the biopsied sites.\n* Vulnerable groups (handicapped, orphans and prisoners).","ALL","25 Years","60 Years",{"count":65,"type":66},30,"ESTIMATED","INTERVENTIONAL",[69],"PHASE4","In oral lichen planus ,Tumor necrosis factor-alpha (TNF-α) has a role in the progression of the disease, enhancing CD8+ cytotoxic T cells and plays a role in the malignant transformation of the lesion. IL-10 is an anti-inflammatory cytokine that controls the disease and maintain homeoastasis. Treatment for OLP includes corticosteroids which is the gold standard, although they have considerable side effects. The use of herbal medicine as an alternative therapy seems promising. Coconut oil has anti-inflammatory, antioxidant, and immunomodulatory properties, no adverse effects, easily available, cost-effective and simply extracted.The aim of this randomized controlled clinical trial is to compare the therapeutic effects of topical 50% coconut mucobioadhesive gel versus topical corticosteroid gel in the management of symptomatic OLP clinically and using biochemical analysis",[72],"Oral Lichen Planus",[74,75,76,77],"Oral lichen planus","coconut oil","TNF-alpha","IL-10","NOT_YET_RECRUITING","2025-08-01",{"date":81,"type":82},"2025-08-06","ACTUAL",{"date":84,"type":66},"2026-01-01",{"date":86,"type":66},"2027-12-01",{"name":5,"class":6}]