[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575746":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":58,"collaborators":18,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":18,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":90,"whyStopped":18,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Microsurgery with Platelet Rich Fibrin","EXPERIMENTAL","Patents will have a blood draw completed so that PRF can be made. Endodontic microsurgery will then be completed. Prior to closing the flap, PRF will be placed in the osteotomy.",[13],"Biological: Platelet rich fibrin",{"label":15,"type":16,"description":17,"interventionNames":18},"Microsurgery Alone","NO_INTERVENTION","Endodontic microsurgery will be completed without PRF. The osteotomy will remain empty as per standard procedure.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BIOLOGICAL","Platelet rich fibrin","Platelet rich fibrin will be used to fill an osteotomy after endodontic microsurgery is completed.",[9],[26],{"name":27,"affiliation":18,"role":28},"Mark Schachman, DMD","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Dawn Dawson, RDH, CCRC","CONTACT","8593235409","ddaws1@uky.edu",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Michael Skanchy, DMD","859-562-2232","msk232@uky.edu",[40],{"facility":41,"status":18,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"University of Kentucky College of Dentistry Endodontics Division","Lexington","Kentucky","40508","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-84.47772,37.98869,{"lat":51,"lon":50},[54,57],{"name":27,"role":32,"phone":55,"phoneExt":18,"email":56},"8593238575","mark.schachman@uky.edu",{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Mark Schachman","Post Graduate Program Director in Endodontics","100575746","phase-4-endodontic-microsurgery-100575746",false,"NCT06776289","Endodontic Microsurgery","Endodontic Microsurgery With and Without Platelet-Rich Fibrin","EMS","Inclusion Criteria:\n\n* Maxillary or Mandibular Anterior teeth and premolars #4-13 and #20-29 with a history of failing RCT and a periapical radiolucency will be accepted\n\nExclusion Criteria:\n\n* Patients with vertical root fractures\n* Patients with non-restorable teeth\n* Patients with class 3 mobility\n* Pregnant\n* Smoker\n* Systematic disease contraindicating surgery","ALL","18 Years","90 Years",{"count":74,"type":75},20,"ESTIMATED","INTERVENTIONAL",[78],"PHASE4","Current literature on platelet rich fibrin (PRF) use in apicoectomies, also known as endodontic microsurgery, is sparse. PRF use in oral surgery or periodontal surgery has been more thoroughly researched. Whether it is able to reduce post-op pain or if it improves success rate in endodontic microsurgery is not well known. It is also not well known if it will be able to increase the rate of healing. This study will evaluate the success of endodontic microsurgery with and without PRF.",[81],"Apical Periodontitis",[83,84,85,86,87,88,89],"endo","endodontic","microsurgery","apicoectomy","apico","prf","platelet rich fibrin","NOT_YET_RECRUITING","2026-01-14",{"date":93,"type":94},"2026-01-16","ACTUAL",{"date":96,"type":75},"2026-03",{"date":98,"type":75},"2026-12-30",{"name":60,"class":6},1]