[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566659":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":40,"collaborators":25,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":25,"enrollmentInfo":54,"targetDuration":25,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":77,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":25},{"fullName":5,"class":6},"University of Southern California","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A (control)","ACTIVE_COMPARATOR","Patients will receive an erector spinae plane block (ESPB) with 20 cc solution per single-shot injection comprised of 0.25% bupivacaine and 0.9% normal saline under ultrasound guidance to be administered bilaterally (40 cc total).",[13],"Drug: Control (Standard treatment)",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B (Intervention)","Patients will receive ESPB with 20cc solution per single-shot injection comprised of 0.25% bupivacaine, 25mcg dexmedetomidine, and 5mg dexamethasone under ultrasound guidance to be administered bilaterally (40 cc total). This is in addition to the bupivacaine.",[18],"Drug: Adjuvant analgesia",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Adjuvant analgesia","Patients will receive adjuvant dexmedetomidine (25mcg) and dexamethasone (5mg) in addition to bupivacaine.",[15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Control (Standard treatment)","Patient will receive standard ESPB with bupivacaine and normal saline",[9],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Paul S Lee","CONTACT","(323) 442-7400","pauls.lee@med.usc.edu",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"Ram K Alluri, MD","(323) 442-5300","ram.alluri@med.usc.edu",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Paul S. Lee","Associate Professor","100566659","phase-4-erector-spinae-plan-block-espb-with-dexmedetomidine-and-dexamethasone-in-lumbar-spine-fusion-100566659",false,"NCT06658054","Erector Spinae Plan Block (ESPB) with Dexmedetomidine and Dexamethasone in Lumbar Spine Fusion","Analgesic Efficacy of Erector Spinae Plane Block with Dexmedetomidine and Dexamethasone As Adjuvants in Single to Three-Level Lumbar Spine Fusion","ESPB","Inclusion Criteria:\n\n* Medically optimized patients undergoing 1-3 level lumbar fusion surgery for treatment of degenerative lumbar spinal pathologies\n* Aged 18 years or older\n* English-speaking patients\n\nExclusion Criteria:\n\n* Patients with surgical indications for infection, malignancy, or trauma\n* women who are pregnancy or breastfeeding\n* Patients with respiratory compromise\n* Patients who are smokers\n* Patients with allergies to local anesthetics, and\u002For opioid medications","ALL","18 Years",{"count":55,"type":56},46,"ESTIMATED","INTERVENTIONAL",[59],"PHASE4","This study wants to understand if using a pre-operative anesthetic injection could contribute to better pain relief after the surgery. This injection is referred to as an erector spinae plane block (ESPB, or \"Block\" for short). In the past, blocks have been commonly used to alleviate different types of pain, including pain following lumbar spine surgery, but our investigators are curious to study if adding two additional commonly used drugs could improve pain relief following surgery when used together. This possibility for improvement in pain management is important for our doctors to study because they want to find ways to reduce the amount of pain medication required after surgery.\n\nWe try to assess if one treatment is better than the other by looking into the amount of pain medication used immediately after the surgery (up to five times within the first 2 days; this is usually done by reviewing progress notes) and by asking patients if they can share with us their pain experienced at different times during their stay at the hospital and at 2-weeks after their procedure.",[62],"Lumbar Degenerative Disease",[64,50,65,66,67,68,69,70,71,72,73,74,75,76],"analgesia","erector spinae plane block","dexmedetomidine","dexamethasone","bupivacaine","randomized","blinded","postoperative","opioid","PONV","nausea","vomitting","fusion","NOT_YET_RECRUITING","2024-10-22",{"date":80,"type":81},"2024-10-26","ACTUAL",{"date":83,"type":56},"2024-11",{"date":85,"type":56},"2026-11",{"name":5,"class":6}]