[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555511":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":18,"centralContacts":35,"locations":41,"responsibleParty":57,"collaborators":18,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":18,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":18,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":18,"overallStatus":44,"whyStopped":18,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"study group","EXPERIMENTAL","Patient will have extraction of teeth and placement of Erythropoietin carried on chitosan carrier for six months",[13],"Drug: Erythropoietin carried on chitosan carrier",{"label":15,"type":16,"description":17,"interventionNames":18},"control","NO_INTERVENTION","Patient will have extraction of teeth only and followup",null,{"label":20,"type":21,"description":22,"interventionNames":23},"positive control","ACTIVE_COMPARATOR","Patient will have extraction of teeth and placement of chitosan carrier only for six months",[24],"Other: chitosan carrier",[26,31],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":18},"DRUG","Erythropoietin carried on chitosan carrier","Patient will have extraction of teeth and placement of Erythropoietin carried on chitosan carrier for six months to enhance bone healing",[9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":18},"chitosan carrier","inert scaffold agent",[20],[36],{"name":37,"role":38,"phone":39,"phoneExt":18,"email":40},"Marwa El Kassaby","CONTACT","01001741212","marwaelkassaby@dent.asu.edu.eg",[42],{"facility":43,"status":44,"city":45,"state":18,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Faculty of Dentistry Ain Shams University","RECRUITING","Cairo","11361","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],31.24967,30.06263,{"lat":53,"lon":52},[56],{"name":37,"role":38,"phone":18,"phoneExt":18,"email":18},{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","shehad wael","Doctor","100555511","phase-4-evaluation-of-erythropoietin-on-alveolar-ridge-preservation-100555511",false,"NCT06513039","Evaluation of Erythropoietin on Alveolar Ridge Preservation","Evaluation of Erythropoietin on Alveolar Ridge Preservation: (A Randomized Controlled Clinical Trial With Histomorphometric Assessment)","Inclusion Criteria:\n\n1. Age range (18-40).\n2. Hopeless teeth indicated for extraction such as root fractures, caries, internal root resorption, external root resorption, endodontic failures.\n3. Systemically free patients using Cornell Medical Index-Health Questionnaire \\[36\\].\n4. Patients diagnosed with intact surrounding alveolar bone (socket type I) \\[37\\].\n5. Maxillary anterior teeth and\u002For premolars indicated for extraction.\n6. Enough zone of keratinized tissue (≥2 mm).\n\nExclusion Criteria:\n\n1. Smokers\n2. Occlusal trauma at the site of the graft\n3. Pregnancy and lactation\n4. Bad compliance with the plaque control instructions following initial therapy.",true,"ALL","18 Years","40 Years",{"count":73,"type":74},15,"ESTIMATED","INTERVENTIONAL",[77],"PHASE4","regenerative materials would help in decreasing post-extraction resorption in sites indicated for placement of a conventional bridge or prosthetically driven implant. Erythropoietin (EPO) is a growth factor that promotes angiogenesis and bone regeneration by stimulating osteoblastic differentiation and by inhibiting osteoclastic resorption. Post-extraction alveolar ridge resorption creates morphological and volumetric changes. These changes can be considered of clinical value that may threaten the placement of a conventional bridge or an implant-supported crown. Atwood et al. \\[1\\] in a cephalometric study categorized factors influencing the rate of alveolar ridge resorption into 4 types: anatomic, metabolic, functional, and prosthetic. As stated by Tan et al. \\[2\\] in a systematic review of alveolar hard and soft tissue dimensional changes in humans post-extraction, they found that alveolar ridge resorption occurs to a greater extent in a horizontal direction than vertical. Therefore, alveolar ridge preservation (ARP) procedures were introduced in an attempt to prevent hard and soft tissue dimensional changes following extraction.",[80],"Alveolar Bone Loss","2024-07-19",{"date":83,"type":84},"2024-07-22","ACTUAL",{"date":86,"type":84},"2024-01-01",{"date":88,"type":74},"2025-01-01",{"name":5,"class":6},1]