[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642566":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":44,"responsibleParty":59,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":26,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":26,"enrollmentInfo":71,"targetDuration":26,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":84,"overallStatus":86,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Liposomal bupivacaine group","EXPERIMENTAL","Participants in this arm will receive a single preoperative ultrasound-guided supra-inguinal fascia iliaca block. The mixture used for nerve block will consist of 10 mL of 0.5% plain bupivacaine plus 20 mL of liposomal bupivacaine (266 mg), for a total volume of 30 mL. The mixture will be injected after negative aspiration and under real-time ultrasound visualization to confirm correct needle tip position between the fascia iliaca and the iliacus muscle. The block will be performed in the preoperative holding area.",[13],"Drug: Liposomal bupivacaine (LB)",{"label":15,"type":16,"description":17,"interventionNames":18},"Plain bupivacaine group","ACTIVE_COMPARATOR","Participants in this arm will receive a single preoperative ultrasound-guided supra-inguinal fascia iliaca block. The mixture used for nerve block will consist of 30 mL of 0.5% plain bupivacaine (total 150 mg). The mixture will be injected after negative aspiration and under real-time ultrasound visualization to confirm correct needle tip position between the fascia iliaca and the iliacus muscle. The block will be performed in the preoperative holding area.",[19],"Drug: Plain bupivacaine",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Liposomal bupivacaine (LB)","A single preoperative ultrasound-guided supra-inguinal fascia iliaca block will be perfomed using a mixture of 10 mL of 0.5% plain bupivacaine plus 20 mL of liposomal bupivacaine (266 mg), total volume 30 mL. The injection will be performed after negative aspiration and under real-time ultrasound visualization to ensure proper spread between the fascia iliaca and the iliacus muscle. The block will be performed in the preoperative holding area.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Plain bupivacaine","A single preoperative ultrasound-guided supra-inguinal fascia iliaca block will be performed using 30 mL of 0.5% plain bupivacaine (150 mg). The injection will be performed after negative aspiration and under real-time ultrasound visualization to ensure proper spread between the fascia iliaca and the iliacus muscle. The block will be performed in the preoperative holding area.",[15],[32],{"name":33,"affiliation":5,"role":34},"Dong-Xin Wang, MD, PhD","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","010-83572784","wangdongxin@hotmail.com",{"name":41,"role":37,"phone":42,"phoneExt":26,"email":43},"Zhen Zhang, MD","+86 13681035526","zhangzhen1st@163.com",[45],{"facility":5,"status":26,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Beijing","Beijing Municipality","100034","China","CN",{"type":52,"coordinates":53},"Point",[54,55],116.39723,39.9075,{"lat":55,"lon":54},[58],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},{"type":34,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Dong-Xin Wang","Chief Physician, Professor","100642566","phase-4-fascia-iliaca-block-using-liposomal-bupivacaine-for-analgesia-after-hip-fracture-surgery-100642566",false,"NCT07643792","Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery","Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery: a Randomized Trial","Inclusion Criteria:\n\n* Aged ≥ 55 years.\n* Diagnosed as hip fracture and scheduled to undergo hip replacement surgery.\n* Agree to receive regional nerve block and postoperative patient-controlled intravenous analgesia (PCIA).\n\nExclusion Criteria:\n\n* Inability to communicate due to visual, auditory, language, or other reasons before surgery.\n* Chronic opioid dependence and long-term use of various types of analgesics (for more than 3 months).\n* Severe coagulation abnormalities (International Normalized Ratio \\> 1.7, activated partial thromboplastin time exceeding the normal value by more than 4 seconds, platelet count \\\u003C 80 × 10⁹\u002FL), trauma or infection at the intended puncture site, or severe low back pain.\n* Preoperative severe renal insufficiency (serum creatinine \\> 442 μmol\u002FL or requiring renal replacement therapy), hepatic insufficiency (Child-Pugh class C), or ASA physical status \\> IV.\n* Known allergy to local anesthetics.\n* Any other condition that the investigator or attending physician deems unsuitable for participation in the study.","ALL","55 Years",{"count":72,"type":73},148,"ESTIMATED","INTERVENTIONAL",[76],"PHASE4","Older patients with hip fractures often suffer from severe pain. Inadequate analgesia increases the risk of postoperative delirium, myocardial injury, and other complications. Peripheral nerve block is an important component of multimodal analgesia, but conventional local anesthetics (such as plain bupivacaine) provide only approximately 12 hours of analgesic duration, which is far from covering the most painful 72 hours after surgery. Liposomal bupivacaine has a slow-release property, prolonging the analgesic duration up to 72 hours after a single injection. However, its clinical advantages in hip fracture surgery remain controversial. The investigators suppose that, compared with plain bupivacaine alone, preoperative supra-inguinal fascia iliaca block using liposomal bupivacaine combined with plain bupivacaine can further improve analgesia, decrease opioid consumption, and improve postoperative recovery quality within 72 hours in older patients after hip fracture surgery.",[79,80,81,82,83],"Older Adults","Hip Fracture Surgery","Fascia Iliaca Block","Liposomal Bupivacaine","Postoperative Pain",[79,85,81,82,83],"Hip fracture surgery","NOT_YET_RECRUITING","2026-06-11",{"date":89,"type":90},"2026-06-15","ACTUAL",{"date":92,"type":73},"2026-07",{"date":94,"type":73},"2028-08",{"name":5,"class":6},1]