[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100495050":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":44,"centralContacts":49,"locations":60,"responsibleParty":82,"collaborators":54,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":88,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":54,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":110,"overallStatus":63,"whyStopped":54,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"University Hospital, Linkoeping","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"acetated Ringers","EXPERIMENTAL","The circulatory effect of a bolus infusion with 4 ml\u002Fkg body weight of acetated Ringers will be studied. If cardiac output increase with 10% a second bolus will be infused and further studied.",[13],"Drug: acetated Ringers",{"label":15,"type":10,"description":16,"interventionNames":17},"albumin 5%","The circulatory effect of a bolus infusion with 4 ml\u002Fkg body weight of Albumin 5% will be studied. If cardiac output increases with 10% a second bolus will be infused and further studied.",[18],"Drug: albumin 5%",{"label":20,"type":10,"description":21,"interventionNames":22},"albumin 20%","The circulatory effect of a bolus infusion with 1 ml\u002Fkg body weight of Albumin 20% will be studied. If cardiac output increase with 10% a second bolus will be infused and further studied.",[23],"Drug: albumin 20%",[25,33,39],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","After insufflation of carbon dioxide during an abdominal laparoscopic procedure, the first fluid bolus is infused. Circulatory and volume effects are studied. If cardiac output increase a second bolus is infused and studied.",[9],[30,31,32],"Ringer's acetate","ringer acetate","acetate Ringer´s",{"type":26,"name":15,"description":34,"armGroupLabels":35,"otherNames":36},"After insufflation of carbon dioxide during an abdominal laparoscopic procedure, the first bolus of fluid is infused. Circulatory and volume effects are studied. If cardiac output increases a second bolus is infused and studied.",[15],[37,38],"Albumin (Human) 5%","Human Albumin 5%",{"type":26,"name":20,"description":34,"armGroupLabels":40,"otherNames":41},[20],[42,43],"Human Albumin 20%","Albumin (Human) 20%",[45],{"name":46,"affiliation":47,"role":48},"Joachim Zdolsek, MD PhD","Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden","PRINCIPAL_INVESTIGATOR",[50,56],{"name":51,"role":52,"phone":53,"phoneExt":54,"email":55},"Robert Svensson, MD","CONTACT","+4610142305",null,"robert.svensson@regionostergotland.se",{"name":57,"role":52,"phone":58,"phoneExt":54,"email":59},"Hans Bahlmann, MD, PhD","+46101031860","hans.bahlmann@regionostergotland.se",[61],{"facility":62,"status":63,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Vrinnevi Hospital","RECRUITING","Norrköping","Östergötland County","60379","Sweden","SE",{"type":70,"coordinates":71},"Point",[72,73],16.1826,58.59419,{"lat":73,"lon":72},[76,78,81],{"name":51,"role":52,"phone":77,"phoneExt":54,"email":55},"+46101040000",{"name":79,"role":52,"phone":77,"phoneExt":54,"email":80},"Fredrik Schiöler, MD","fredrik.schioler@regionostergotland.se.se",{"name":51,"role":48,"phone":54,"phoneExt":54,"email":54},{"type":83,"investigatorFullName":84,"investigatorTitle":85,"investigatorAffiliation":5,"oldNameTitle":54,"oldOrganization":54},"SPONSOR_INVESTIGATOR","Joachim Zdolsek","consultant, assoc prof","100495050","phase-4-fluid-challenge-and-plasma-volume-during-surgery-100495050",false,"NCT05726136","Fluid Challenge and Plasma Volume, During Surgery","Comparison of Albumin and Ringer's Solution for Optimization of the Plasma Volume and Hemodynamics During Laparoscopic Surgery.","FC-VE","Inclusion Criteria:\n\n* Written consent to participate in the study\n* For women: relevant contraceptive, menopausal or a negative pregnancy test.\n* ASA category I to III\n* Laparoscopic abdominal surgery, with a duration of at least 90 minutes.\n* 18 to 85 years\n\nExclusion Criteria:\n\n* Patients with known cardiac failure\n* \\\u003C18 or \\>85 years\n* known allergy to albumin\n* extracellular hyperhydration or hypervolemia\n* kidney failure\n* pregnancy or planned pregnancy","ALL","18 Years","85 Years",{"count":98,"type":99},60,"ESTIMATED","INTERVENTIONAL",[102],"PHASE4","A short bolus infusion of fluid, called \"fluid challenge\" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml\u002Fkg body weight, albumin 5% 4 ml\u002Fkg body weight or albumin 20% 1 ml\u002Fkg body weight), using hemoglobin as a dilution indicator.",[105,106,107,108,109],"Colorectal Cancer","Urologic Cancer","Gynecologic Cancer","Colorectal Disorders","Benign Neoplasm",[111],"laparoscopic surgery, fluid therapy, plasma volume","2026-04-24",{"date":114,"type":115},"2026-04-30","ACTUAL",{"date":117,"type":115},"2023-10-23",{"date":119,"type":99},"2026-10-31",{"name":84,"class":6},1]