[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642749":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":37,"centralContacts":46,"locations":52,"responsibleParty":66,"collaborators":11,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":11,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":11,"overallStatus":90,"whyStopped":11,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"MediBeacon Transdermal Glomerular Filtration Rate (GFR) Monitoring","EXPERIMENTAL",null,[13,14,15,16],"Drug: Relmapirazin","Drug: Iohexol","Device: Medibeacon tGFR monitor","Diagnostic Test: Urine creatinine clearance collection",[18,23,27,32],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"DRUG","Relmapirazin","IV push of relmapirazin (Lumitrace) prior to use of the tGFR device",[9],{"type":19,"name":24,"description":25,"armGroupLabels":26,"otherNames":11},"Iohexol","Small IV push bolus of iohexol as a probe for renal function will be administered prior to use of the tGFR device.",[9],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":11},"DEVICE","Medibeacon tGFR monitor","The tGFR monitor will be applied to the patient after relmapirazin bolus for measurement of GFR.",[9],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"DIAGNOSTIC_TEST","Urine creatinine clearance collection","8-hour urine creatinine clearance collection will be performed during the study period to compare to tGFR \\& other renal function measures.",[9],[38,42],{"name":39,"affiliation":40,"role":41},"Aaron M Cook, PharmD","University of Kentucky College of Pharmacy, Department of Pharmacy Practice & Science","PRINCIPAL_INVESTIGATOR",{"name":43,"affiliation":44,"role":45},"Juan-Carlos Aycinena, MD","University of Kentucky College of Medicine, Department of Nephrology","STUDY_DIRECTOR",[47],{"name":48,"role":49,"phone":50,"phoneExt":11,"email":51},"Aaron Cook, PharmD","CONTACT","18592578444","amcook0@uky.edu",[53],{"facility":54,"status":11,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":11},"UKHealthCare\u002FUniversity of Kentucky","Lexington","Kentucky","40536","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-84.47772,37.98869,{"lat":64,"lon":63},{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Aaron Cook","Associate Professor","100642749","phase-4-fluorescent-probe-for-assessment-of-renal-elimination-100642749",false,"NCT07643467","Fluorescent Probe for Assessment of Renal Elimination","FLARE","Inclusion Criteria:\n\n* 18-65 years old\n* critically ill or acutely ill hospitalized patients admitted to the intensive care unit\n* Stable\u002Fnormal renal function\n\nExclusion Criteria:\n\n* Prisoners\n* Pregnant women\n* Laboratory evidence of unstable kidney function (KDIGO AKI stage 1-3--This includes subjects with Scr \\> 1.5x baseline)","ALL","18 Years","65 Years",{"count":81,"type":82},200,"ESTIMATED","INTERVENTIONAL",[85],"PHASE4","Accurate measures of kidney function is important for precision dosing of many medications. The current methods of determining kidney function largely hinge on the use of equations that use common laboratory values such as serum creatinine \\& static variables like age \\& weight. These are helpful for trending over time, but often are inaccurate during times of medical illness. Other more accurate methods of measuring kidney function include urine collection, although this is not commonly used because of various reasons that make the collection inconvenient or unreliable. The new transdermal glomerular filtration (tGFR) device permits accurate, real-time evaluation of kidney function. This novel method has not been rigorously compared with urine collection \\& other methods of determining kidney function in hospitalized patients. The goal of the study is to compare tGFR with other accepted methods of determining kidney function.",[88,89],"Augmented Renal Clearance","Critical Illness","NOT_YET_RECRUITING","2026-06-12",{"date":93,"type":94},"2026-06-16","ACTUAL",{"date":96,"type":82},"2026-07",{"date":98,"type":82},"2028-06-30",{"name":68,"class":6},1]