[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637813":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":23,"centralContacts":23,"locations":24,"responsibleParty":48,"collaborators":23,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":23,"enrollmentInfo":62,"targetDuration":23,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":23,"overallStatus":72,"whyStopped":23,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Dartmouth-Hitchcock Medical Center","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Intraplerual Saline","All patients will be in a single arm and escalated from intraplerual saline to tPA\u002FDNAse followed by surgery as warranted based on protocol criteria.",[12],"Drug: Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.","Though intraplerual alteplase\u002F dornase alfa and normal saline have been established method to reduce complicated pleural infection sizes and rate of surgical interventions, with tPA\u002FDNAse being the gold standards, there has not been a study comparing the two head to head. This trial's purpose is to function as pilot study as a foundation for a potential noninferiorrity trail comparing the two.",[9],[20,21,22],"normal saline","alteplase","dornase alfa",null,[25],{"facility":5,"status":23,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Hanover","New Hampshire","03756","United States","US",{"type":32,"coordinates":33},"Point",[34,35],-72.28954,43.70229,{"lat":35,"lon":34},[38,43,46],{"name":39,"role":40,"phone":41,"phoneExt":23,"email":42},"Adele E Soutar, MD","CONTACT","603-650-5000","adele.e.soutar@hitchcock.org",{"name":44,"role":45,"phone":23,"phoneExt":23,"email":23},"Jimmy Wang, MD","SUB_INVESTIGATOR",{"name":47,"role":45,"phone":23,"phoneExt":23,"email":23},"David Feller-Kopman, MD",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Adele.E.Soutar","Pulmonary and Critical Care Fellow","100637813","phase-4-flush-lyse-operate-100637813",false,"NCT07592520","Flush, Lyse, Operate","Flush, Lyse, Operate: A Pilot Trial of Step-Wise Escalation for Pleural Infection: FLO Trial","FLO","Inclusion Criteria:\n\n* Age 18+\n* Complicated Parapneumonic Effusion or Empyema Requiring Thoracostomy\n* Are able to personally or have a designated medical decision maker provide consent\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Have received any intrapleural medications prior to enrolment via current chest tube\n* Have a contraindication to tPA\u002FDNase:\n\n  * Anticoagulation\n  * Active hemorrhage\n  * Allergy to tPA\u002FDNase\n  * Pregnancy\n* Are unable to personally or do not have a designated medical decision maker provide consent","ALL","18 Years",{"count":63,"type":64},30,"ESTIMATED","INTERVENTIONAL",[67],"PHASE4","The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space. The main question it aims to answer is:\n\nWhat is the time to chest tube removal? Do these patients after need to escalate to fibrinolytics? Do these patients after need to escalate to surgery?\n\nParticipants will:\n\n* Receive receive saline into their pleural space through an existing chest tube\n* If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will receive fibrynolytics through an existing chest tube\n* If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will be referred to surgery.",[70,71],"Complicated Parapneumonic Effusion","Empyema, Pleural","NOT_YET_RECRUITING","2026-05-11",{"date":75,"type":76},"2026-05-18","ACTUAL",{"date":78,"type":64},"2026-04",{"date":80,"type":64},"2027-04",{"name":5,"class":6},1]