[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100523371":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":32,"locations":41,"responsibleParty":61,"collaborators":63,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":31,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":31,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":31,"overallStatus":43,"whyStopped":31,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Delaware","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Salt Resistant Adults","EXPERIMENTAL","Adults who experience minimal BP change during dietary sodium challenge",[13,14],"Drug: Furosemide (Diuretic)","Other: Hypertonic Saline Infusion",{"label":16,"type":10,"description":17,"interventionNames":18},"Salt Sensitive","Adults who experience increased BP (mean arterial pressures \\>5mmHg) during dietary sodium challenge",[13,14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Furosemide (Diuretic)","The diuretic furosemide will be given during a 3% hypertonic saline infusion to examine blockade of the NKCC2.",[9,16],[26],"Lasix",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Hypertonic Saline Infusion","3% Hypertonic saline infusion to acutely increase sodium and osmolality",[9,16],null,[33,38],{"name":34,"role":35,"phone":36,"phoneExt":31,"email":37},"Megan Wenner, PhD","CONTACT","3028317343","mwenner@udel.edu",{"name":39,"role":35,"phone":31,"phoneExt":31,"email":40},"Virginia Nuckols, PhD","gnuckols@udel.edu",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Newark","Delaware","19713","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-75.74966,39.68372,{"lat":53,"lon":52},[56,58],{"name":57,"role":35,"phone":31,"phoneExt":31,"email":40},"Ginny Nuckols, PhD",{"name":59,"role":35,"phone":31,"phoneExt":31,"email":60},"Katherine Masso, BS","kcmasso@udel.edu",{"type":62,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR",[64],{"name":65,"class":66},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100523371","phase-4-forebrain-electroneutral-transporters-in-salt-sensitive-hypertension-an-mri-study-100523371",false,"NCT06094816","Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study","Inclusion Criteria:\n\n* Age: \\> 40 years or \\\u003C 60 years\n* Blood pressure: \\> 100\u002F60 mmHg or \\\u003C 140\u002F90 mmHg\n* BMI: \\> 18.5 kg\u002Fm2 or \\\u003C 35 kg\u002Fm2\n* Serum potassium: \\> 3.5 mmol\u002FL or \\\u003C 5.5 mmol\u002FL\n* No history of cardiovascular, renal, metabolic, or neurological disease\n\nExclusion Criteria:\n\n* Age: \\\u003C 40 years or \\> 60 years\n* Blood pressure: \\\u003C 100\u002F60 mmHg or \\> 140\u002F90 mmHg\n* BMI: \\\u003C 18.5 kg\u002Fm2 or \\> 30 kg\u002Fm2\n* Serum potassium: \\\u003C 3.5 mmol\u002FL or \\> 5.5 mmol\u002FL\n* Abnormal ECG\n* History of - cardiovascular, cancer, metabolic, respiratory, renal disease\n* Hormone replacement therapy\n* Current tobacco or nicotine use\n* Pregnant or nursing mothers\n* Major brain injury (concussions do not count)\n* Clinically diagnosed psychiatric or neurological disorder\n* Clinically diagnosed anxiety or depression\n* Psychiatric, neurological, anxiety or depression medications\n* Hypertension medications\n* Sulfonamide drug allergy\n* Contra-indications to MRI (implants, metal, etc)\n* Claustrophobia",true,"ALL","40 Years","60 Years",{"count":78,"type":79},120,"ESTIMATED","INTERVENTIONAL",[82],"PHASE4","The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.",[85],"Salt-Sensitivity of Blood Pressure","2026-03-20",{"date":88,"type":89},"2026-03-24","ACTUAL",{"date":91,"type":89},"2024-03-05",{"date":93,"type":79},"2028-07-01",{"name":5,"class":6},1]