[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620654":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":24,"responsibleParty":31,"collaborators":24,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":24,"eligibilityCriteria":40,"healthyVolunteers":36,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":24,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":24,"overallStatus":53,"whyStopped":24,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":24},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Granisetron + Dexamethasone","EXPERIMENTAL","Patients will receive granisetron preoperatively, followed by dexamethasone administered after induction of anesthesia for prevention of postoperative nausea and vomiting.",[13],"Drug: Granisetron",{"label":15,"type":10,"description":16,"interventionNames":17},"Granisetron + Metoclopramide","Patients will receive granisetron preoperatively, followed by metoclopramide administered after induction of anesthesia for prevention of postoperative nausea and vomiting.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Granisetron","Granisetron will be administered intravenously preoperatively for prevention of postoperative nausea and vomiting in female patients undergoing laparoscopic cholecystectomy.",[9,15],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Amir Mohamed Abd El Halim Mokhimar","CONTACT","+201030244202","amirmohamed13.16@gmail.com",{"type":32,"investigatorFullName":27,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Anesthesiogy Resident","100620654","phase-4-granisetron-combined-with-dexamethasone-or-metoclopramide-for-ponv-prevention-after-laparoscopic-cholecystectomy-100620654",false,"NCT07360431","Granisetron Combined With Dexamethasone or Metoclopramide for PONV Prevention After Laparoscopic Cholecystectomy","Preoperative Granisetron in Combination With Dexamethasone or Metoclopramide for Prevention of Postoperative Nausea and Vomiting in Female Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n\\- 1- Adult female. 2- (ASA I-II), aged 18-60 years. 3- Non smoker. 4- Scheduled for elective laparoscopic cholecystectomy under general anesthesia.\n\n5- Use of intraoperative opioid analgesics.\n\nExclusion Criteria:\n\n* 1- History of hypersensitivity to study drugs. 2- Chronic antiemetic. 3- Antidepressant use. 4- Gastrointestinal disease. 5- Pregnancy\u002Flactation. 6- Severe hepatic\u002Frenal dysfunction","FEMALE","18 Years","60 Years",{"count":45,"type":46},102,"ESTIMATED","INTERVENTIONAL",[49],"PHASE4","Postoperative nausea and vomiting (PONV) remain common and distressing complications following laparoscopic cholecystectomy, particularly in female patients. This randomized interventional study aims to evaluate the effectiveness of preoperative granisetron when combined with either dexamethasone or metoclopramide in preventing PONV. The study compares the incidence and severity of nausea and vomiting, as well as the need for rescue antiemetic therapy, among female patients undergoing laparoscopic cholecystectomy under general anesthesia.",[52],"Postoperative Nausea and Vomiting (PONV)","NOT_YET_RECRUITING","2026-01-16",{"date":56,"type":57},"2026-01-22","ACTUAL",{"date":59,"type":46},"2026-03",{"date":61,"type":46},"2027-10",{"name":5,"class":6}]