[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606827":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":35,"locations":41,"responsibleParty":81,"collaborators":27,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":87,"sex":93,"minAge":94,"maxAge":27,"enrollmentInfo":95,"targetDuration":27,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":106,"overallStatus":116,"whyStopped":27,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Universität Luzern","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Metronidazol\u002FNeomycin","ACTIVE_COMPARATOR","Currently the most frequently used antibiotics for gut decolonisation prior to colon surgery (Standard of care)",[13,14],"Drug: Metronidazole","Drug: Neomycin Sulfate",{"label":16,"type":17,"description":18,"interventionNames":19},"Rifaximin","EXPERIMENTAL","Antibiotic with poorly systemic resorption after oral administration, under investigation as an agent for gut decolonization before colon surgery",[20],"Drug: Rifaximin (Xifaxan)",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Rifaximin (Xifaxan)","Preoperative gut decolonization protocol based on oral Rifaximin 2x550mg 10 am and 10 pm on the day preceding the surgery",[16],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Metronidazole","Preoperative gut decolonization protocols based on oral Neomycine 2x500mg and Metronidazole 2x500mg 10 am and 10pm on the day preceding the surgery",[9],{"type":23,"name":33,"description":30,"armGroupLabels":34,"otherNames":27},"Neomycin Sulfate",[9],[36],{"name":37,"role":38,"phone":39,"phoneExt":27,"email":40},"Rami Sommerstein, Prof. Dr. Med.","CONTACT","+41 41 208 32 54","rami.sommerstein@unilu.ch",[42,54,63,72],{"facility":43,"status":27,"city":44,"state":27,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":27},"Kantonsspital Aarau","Aarau","5001","Switzerland","CH",{"type":49,"coordinates":50},"Point",[51,52],8.04422,47.39254,{"lat":52,"lon":51},{"facility":55,"status":27,"city":56,"state":27,"zip":57,"country":46,"countryCode":47,"cosmosGeoPoint":58,"geoPoint":62,"contacts":27},"Luzerner Kantonsspital","Lucerne","6006",{"type":49,"coordinates":59},[60,61],8.30635,47.05048,{"lat":61,"lon":60},{"facility":64,"status":27,"city":65,"state":27,"zip":66,"country":46,"countryCode":47,"cosmosGeoPoint":67,"geoPoint":71,"contacts":27},"Kantonsspital St. Gallen","Sankt Gallen","9007",{"type":49,"coordinates":68},[69,70],9.37477,47.42391,{"lat":70,"lon":69},{"facility":73,"status":27,"city":74,"state":27,"zip":75,"country":46,"countryCode":47,"cosmosGeoPoint":76,"geoPoint":80,"contacts":27},"Stadtspital Triemli","Zurich","8063",{"type":49,"coordinates":77},[78,79],8.55,47.36667,{"lat":79,"lon":78},{"type":82,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Rami Sommerstein","Prof. Dr. Med.","100606827","phase-4-gut-decolonisation-with-neomycinmetronidazole-or-rifaximin-before-colon-surgery-100606827",false,"NCT07180615","Gut Decolonisation With Neomycin\u002FMetronidazole or Rifaximin Before Colon Surgery","Neomycine\u002FMetronidazole- vs Rifaximin-based Gut Decolonisation Prior to Colon Surgery: a Randomized Multicenter Trial","NeoRiDe","Inclusion Criteria:\n\n* aged ≥ 18 years\n* undergoind planned colon surgery\n* colon surgery will be included in Swissnoso SSI surveillance\n* informed consent\n\nExclusion Criteria:\n\n* contraindications and\u002For intolerance to one of the study compounds\n* patients with underlying active infection (wound contamination class IV) at the timepoint of incision\n* pregnant women\n* unable to follow study protocol","ALL","18 Years",{"count":96,"type":97},458,"ESTIMATED","INTERVENTIONAL",[100],"PHASE4","The goal of this clinical trial is to find out if a gut cleaning using Rifaximin works as well as the usual treatment with Neomycin and Metronidazole to prevent infections after colon surgery. The study includes adult patients who will have colon surgery.\n\nThe main question it aims to answer are:\n\n-Does the Rifaximin treatment prevent surgical site infections as well as the Neomycin\u002FMetronidazole treatment?\n\nOther things the study will look at:\n\n* How often infections happen, stratified on how deep they are, the type of surgery the patients got, or if bowel cleaning was done before surgery.\n* How many people will die after surgery\n* How long people stay in hospital\n\nParticipants will:\n\n* Take either Rifaximin or Neomycin\u002FMetronidazole one day before surgery to clean their gut\n* Keep a diary until the surgery to record medication intake and any side effects\n* Be contacted by phone 30 days after surgery to ask about their condition and any side effects,",[103,104,105],"Surgical Site Infection","Colon Surgery","Surgical Site Infections",[107,108,109,110,111,112,113,114,115],"SSI","surgical site infection","Metronidazol","flagyl","neomycine","rifaximin","colon surgery","antibiotics","preoperative decolonisation","NOT_YET_RECRUITING","2025-09-11",{"date":119,"type":120},"2025-09-18","ACTUAL",{"date":122,"type":97},"2026-06-01",{"date":124,"type":97},"2029-06-30",{"name":5,"class":6},4]