[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613609":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":33,"locations":39,"responsibleParty":120,"collaborators":32,"id":123,"slug":124,"hasResults":125,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":125,"sex":131,"minAge":132,"maxAge":32,"enrollmentInfo":133,"targetDuration":32,"studyType":136,"phases":137,"briefSummary":139,"conditions":140,"keywords":32,"overallStatus":42,"whyStopped":32,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},{"fullName":5,"class":6},"Incheon St.Mary's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Zastaprazan","EXPERIMENTAL","Zastaprazan 20 mg, once daily, preferably administered orally in the morning before breakfast for four weeks",[13],"Drug: Zastaprazan",{"label":15,"type":16,"description":17,"interventionNames":18},"Esomeprazole","ACTIVE_COMPARATOR","Esomeprazole 40 mg, once daily, preferably administered orally in the morning before breakfast for four weeks",[19],"Drug: Esomeprazole",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Participants in this arm will receive zastaprazan. This group serves as the experimental treatment group exploratorily evaluating drug for GERD.",[9],[26],"P-CAB",{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Participants in this arm will receive esomeprazole. This group serves as the active comparator treatment group exploratorily evaluating drug for GERD.",[15],[31],"PPI",null,[34],{"name":35,"role":36,"phone":37,"phoneExt":32,"email":38},"Byung-Wook Kim","CONTACT","+82-1544-9004","gastro@catholic.ac.kr",[40,51,59,67,75,83,94,102,107,112],{"facility":41,"status":42,"city":43,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":45,"geoPoint":50,"contacts":32},"Korea University Ansan Hospital","RECRUITING","Ansan","South Korea",{"type":46,"coordinates":47},"Point",[48,49],126.52613,35.46836,{"lat":49,"lon":48},{"facility":52,"status":42,"city":53,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":54,"geoPoint":58,"contacts":32},"Pusan National University Hospital","Busan",{"type":46,"coordinates":55},[56,57],129.03004,35.10168,{"lat":57,"lon":56},{"facility":60,"status":42,"city":61,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":62,"geoPoint":66,"contacts":32},"Kyungpook National University Chilgok Hospital","Chilgok",{"type":46,"coordinates":63},[64,65],128.39785,35.99251,{"lat":65,"lon":64},{"facility":68,"status":42,"city":69,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":70,"geoPoint":74,"contacts":32},"Hallym University Chuncheon Sacred Heart Hospital","Chuncheon",{"type":46,"coordinates":71},[72,73],127.73417,37.87472,{"lat":73,"lon":72},{"facility":76,"status":42,"city":77,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":78,"geoPoint":82,"contacts":32},"Chonnam National University Hospital","Gwangju",{"type":46,"coordinates":79},[80,81],126.91556,35.15472,{"lat":81,"lon":80},{"facility":84,"status":42,"city":85,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Catholic University of Korea, Incheon ST. Mary's Hospital","Incheon",{"type":46,"coordinates":87},[88,89],126.70515,37.45646,{"lat":89,"lon":88},[92],{"name":35,"role":36,"phone":93,"phoneExt":32,"email":38},"82-2-1544-9004",{"facility":95,"status":42,"city":96,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":97,"geoPoint":101,"contacts":32},"Gangnam Severance Hospital","Seoul",{"type":46,"coordinates":98},[99,100],126.9784,37.566,{"lat":100,"lon":99},{"facility":103,"status":42,"city":96,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":104,"geoPoint":106,"contacts":32},"Kyung Hee University Hospital",{"type":46,"coordinates":105},[99,100],{"lat":100,"lon":99},{"facility":108,"status":42,"city":96,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":109,"geoPoint":111,"contacts":32},"Soonchunhyang University Hospital",{"type":46,"coordinates":110},[99,100],{"lat":100,"lon":99},{"facility":113,"status":42,"city":114,"state":32,"zip":32,"country":44,"countryCode":32,"cosmosGeoPoint":115,"geoPoint":119,"contacts":32},"Pusan National University Yangsan Hospital","Yangsan",{"type":46,"coordinates":116},[117,118],129.03358,35.34199,{"lat":118,"lon":117},{"type":121,"investigatorFullName":35,"investigatorTitle":122,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Professor","100613609","phase-4-heartburn-gastroesophageal-reflux-disease-100613609",false,"NCT07268820","Heartburn, Gastroesophageal Reflux Disease","A Multicenter, Double-blind, Randomized, Investigator-initiated Trial to Evaluate the Degree of Symptom Relief of Zastaprazan and Esomeprazole in Patients With Erosive Reflux Disease With Night-time Heartburn Symptoms","GERD","Inclusion Criteria:\n\n1. Korean adults aged 19 years or older as of the date of written consent\n2. Those diagnosed with erosive gastroesophageal reflux disease based on upper gastrointestinal endoscopy (EGD)\n3. Those who reported nighttime heartburn for more than 3 months at the time of screening (Visit 1)\n4. Those who voluntarily decided to participate and provide written informed consent\n\nExclusion Criteria:\n\n1. Those who cannot undergo upper gastrointestinal endoscopy (EGD)\n2. Individuals with a history of drug or alcohol abuse (within the past year)\n3. Individuals who have received other investigational products within one month prior to the screening visit (Visit 1)\n4. In addition to the above, individuals with clinically significant findings that the investigator deems medically inappropriate for the present study","ALL","19 Years",{"count":134,"type":135},160,"ESTIMATED","INTERVENTIONAL",[138],"PHASE4","Gastroesophageal reflux disease (GERD) is a condition caused by the reflux of stomach contents into the esophagus, presenting with typical symptoms such as heartburn and acid regurgitation.\n\nGERD is a chronic condition that affects quality of life, and patients with this condition are known to have a lower quality of life compared to healthy individuals. In particular, nocturnal heartburn can lead to sleep deprivation and affect daily life, as well as overall quality of life.\n\nThis study aims to evaluate the efficacy of alleviating nocturnal heartburn symptoms in patients with erosive reflux disease (ERD).",[129],"2025-12-16",{"date":143,"type":144},"2025-12-23","ACTUAL",{"date":146,"type":144},"2025-07-07",{"date":148,"type":135},"2026-09-30",{"name":5,"class":6},10]