[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617730":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":11,"centralContacts":51,"locations":57,"responsibleParty":74,"collaborators":11,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":11,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":11,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":60,"whyStopped":11,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Mansoura University","OTHER",[8,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Norepinephrine","EXPERIMENTAL",null,[13,14,15,16,17],"Procedure: Spinal Anesthesia with Bupivacaine and Fentanyl","Drug: Crystalloid Coload 1000 mL","Procedure: Cesarean Delivery","Radiation: Transthoracic Echocardiography","Drug: Intravenous Norepinephrine Bolus",{"label":19,"type":20,"description":11,"interventionNames":21},"Ephedrine","ACTIVE_COMPARATOR",[13,14,15,16,22],"Drug: Intravenous Ephedrine Bolus",[24,29,34,38,43,47],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"PROCEDURE","Spinal Anesthesia with Bupivacaine and Fentanyl","Spinal anesthesia using 2.5 mL of 0.5% hyperbaric bupivacaine (12.5 mg) and 15 mcg of fentanyl at the L4-L5 or L3-L4 interspace",[19,9],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"DRUG","Crystalloid Coload 1000 mL","Ringer acetate 1000 mL will be administered over 10 minutes starting immediately after intrathecal injection",[19,9],{"type":25,"name":35,"description":36,"armGroupLabels":37,"otherNames":11},"Cesarean Delivery","Lower segment cesarean section using the Pfannenstiel incision and uterine exteriorization",[19,9],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":11},"RADIATION","Transthoracic Echocardiography","Measurement of cardiac output in supine position with left lateral tilt at baseline, at 1 and 10 minutes after intrathecal injection, and immediately after delivery",[19,9],{"type":30,"name":44,"description":45,"armGroupLabels":46,"otherNames":11},"Intravenous Norepinephrine Bolus","Prophylactic IV norepinephrine bolus of 6 mcg will be administered immediately after intrathecal injection, followed by rescue IV norepinephrine boluses of 3, 6, and 9 mcg when systolic blood pressure decreases below 90%, 80%, and 70% of baseline value, respectively",[9],{"type":30,"name":48,"description":49,"armGroupLabels":50,"otherNames":11},"Intravenous Ephedrine Bolus","Prophylactic IV ephedrine bolus of 6 mg will be administered immediately after intrathecal injection, followed by rescue IV ephedrine boluses of 3, 6, and 9 mg when systolic blood pressure decreases below 90%, 80%, and 70% of baseline value, respectively",[19],[52],{"name":53,"role":54,"phone":55,"phoneExt":11,"email":56},"Mohamed M Tawfik, MD","CONTACT","0020 1001183400","m2tawfik@mans.edu.eg",[58],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Department of Anesthesia and Surgical Critical Care, Mansoura University Hospitals","RECRUITING","Al Mansurah","Dakahlia Governorate","35511","Egypt","EG",{"type":67,"coordinates":68},"Point",[69,70],31.38069,31.03637,{"lat":70,"lon":69},[73],{"name":53,"role":54,"phone":55,"phoneExt":11,"email":56},{"type":75,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Mohamed Mohamed Tawfik","Associate Professor","100617730","phase-4-hemodynamics-during-cesarean-delivery-under-spinal-anesthesia-with-norepinephrine-versus-ephedrine-100617730",false,"NCT07322419","Hemodynamics During Cesarean Delivery Under Spinal Anesthesia With Norepinephrine Versus Ephedrine","Echocardiographic Evaluation of Cardiac Output During Cesarean Delivery Under Spinal Anesthesia Using Norepinephrine Versus Ephedrine: A Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists physical status II.\n* Singleton, full term pregnancy.\n* Scheduled cesarean delivery under spinal anesthesia.\n\nExclusion Criteria:\n\n* Height \\\u003C150 or \\>180 cm.\n* Weight \\\u003C60 or \\>110 kg.\n* Body mass index (BMI) \\\u003C18.5 or ≥35 kg\u002Fm².\n* Women presenting in labor.\n* Any contraindication to spinal anesthesia: increased intracranial pressure, coagulopathy, or local skin infection.\n* Chronic or pregnancy-induced hypertension.\n* Baseline systolic blood pressure \\>140 mm Hg.\n* Hemoglobin \\\u003C10 g\u002Fdl.\n* Diabetes mellitus, cardiovascular, cerebrovascular, or renal disease.\n* Polyhydramnios or known significant fetal abnormalities.\n* Current administration of vasoactive drugs such as: beta blockers, salbutamol, or thyroxin.","FEMALE","19 Years","40 Years",{"count":89,"type":90},200,"ESTIMATED","INTERVENTIONAL",[93],"PHASE4","Echocardiography will be used to measure cardiac output and calculate other important hemodynamic variables in healthy patients with full-term singleton pregnancy during cesarean delivery under conventional spinal anesthesia using 2 different vasopressor drugs: norepinephrine in 1 group versus ephedrine in another group.",[35,96],"Spinal Anesthesia for Cesarean Section",[98,99,100,101],"Cesarean delivery","Spinal anesthesia","Echocardiography","Hemodynamics","2026-01-12",{"date":104,"type":105},"2026-01-14","ACTUAL",{"date":107,"type":105},"2026-01-01",{"date":109,"type":90},"2026-12-31",{"name":5,"class":6},1]