[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618235":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":33,"responsibleParty":57,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":25,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":85,"overallStatus":94,"whyStopped":25,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Shortened-Duration Corticosteroids","EXPERIMENTAL","Discontinue adjunctive systemic corticosteroids at day 10 of therapy or at hospital discharge (whichever occurs first), after documented clinical recovery (room air for ≥6 hours).",[13],"Drug: Systemic corticosteroids",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard duration of Corticosteroids","ACTIVE_COMPARATOR","Continue adjunctive systemic corticosteroids to a total of 21 days (standard of care).",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Systemic corticosteroids","Adjunctive systemiccorticosteroid therapy administered as part of standard treatment for pneumocystis Pneumonia, with duration varying by study arm.",[9,15],null,[27],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},"Babykumari Chitramuthu, PhD","CONTACT","15149341934","23730","babykumari.chitramuthu@muhc.mcgill.ca",[34],{"facility":35,"status":25,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"McGill university Health Centre (Royal victoria Hospital and Montreal General Hospital","Montreal","Quebec","H4A 3J1","Canada","CA",{"type":42,"coordinates":43},"Point",[44,45],-73.58781,45.50884,{"lat":45,"lon":44},[48,50,53,55],{"name":28,"role":29,"phone":49,"phoneExt":31,"email":32},"5149341934",{"name":51,"role":52,"phone":25,"phoneExt":25,"email":25},"Emily G McDonald, MD MSc","PRINCIPAL_INVESTIGATOR",{"name":54,"role":52,"phone":25,"phoneExt":25,"email":25},"Todd C Lee, MD MPH FIDSA",{"name":56,"role":52,"phone":25,"phoneExt":25,"email":25},"Matthew P Cheng, MDCM, FRCPC, FACP, DABMM",{"type":52,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Emily McDonald","Associate professor of medicine","100618235","phase-4-how-long-should-we-give-steroids-for-patients-with-severe-pcp-100618235",false,"NCT07328984","How Long Should we Give Steroids for Patients With Severe PCP","How Long Should we Give Steroids for Patients With Severe PCP (HOW LONG)","HOW LONG","Inclusion Criteria:\n\n* Age ≥18 years\n* Proven or probable Pneumocystis jirovecii pneumonia\n* Severe PCP requiring supplemental oxygen (e.g., ≥4 L\u002Fmin or ≥35% FiO₂ to maintain SpO₂ ≥94%)\n* Planned or receiving adjunctive systemic corticosteroid therapy for severe PCP\n* Clinical recovery by day 10 of steroid therapy: breathing room air for ≥6 hours\n* Able to provide informed consent (or per local requirements)\n\nExclusion Criteria:\n\n* Persistent hypoxemia or ongoing oxygen requirement at day 10\n* Clinical deterioration prior to randomization\n* Treating clinician determines steroids must be continued or stopped immediately for medical reasons\n* Anticipated death within 48 hours\n* Inability or unwillingness to complete follow-up through day 180","ALL","18 Years",{"count":71,"type":72},416,"ESTIMATED","INTERVENTIONAL",[75],"PHASE4","The HOW LONG trial is an international, multicenter, Phase IV randomized clinical trial evaluating the optimal duration of adjunctive systemic corticosteroids in immunocompromised adults with severe Pneumocystis jirovecii pneumonia (PCP) who demonstrate early clinical recovery. Participants who no longer require supplemental oxygen by day 10 of corticosteroid therapy are randomized to discontinue corticosteroids at day 10 (or hospital discharge, if earlier) versus continue corticosteroids for a total of 21 days. The trial assesses whether earlier discontinuation reduces steroid-related complications while maintaining clinical outcomes.",[78,79,80,81,82,83,84],"Pneumocystis Pneumonia","Pneumocystis","Pneumocystis Jirovecii Infection","Pneumocystis Jiroveci Pneumonia","Pneumocystis Carinii; Infection, Resulting From HIV Disease","Pneumocystosis Associated With AIDS","Pneumocystosis; Pneumonia (Etiology)",[86,87,88,89,90,91,92,93],"PCP","Systemic Corticosteroids","De-escalation of Therapy","Randomized Control Trial","Immunocompromised host","HIV","Non-HIV","Pneumocystis jirovecii pneumonia","NOT_YET_RECRUITING","2025-12-27",{"date":97,"type":98},"2026-01-09","ACTUAL",{"date":100,"type":72},"2026-01-30",{"date":102,"type":72},"2029-06",{"name":5,"class":6},1]