[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631712":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":41,"responsibleParty":47,"collaborators":41,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":41,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":74,"whyStopped":41,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":41},{"fullName":5,"class":6},"All India Institute of Medical Sciences, Bhubaneswar","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A - Hyaluronic Acid","EXPERIMENTAL","Hyaluronic Acid",[13],"Drug: Hyaluronic Acid (HA)",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B - Mitomycin-C","ACTIVE_COMPARATOR","Mitomycin-C",[19],"Drug: Mitomycin -C",[21,27],{"type":22,"name":23,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Hyaluronic Acid (HA)",[9],[26],"Aurogel",{"type":22,"name":28,"description":28,"armGroupLabels":29,"otherNames":30},"Mitomycin -C",[15],[31],"Mitomycin 2",[33],{"name":34,"affiliation":35,"role":36},"Sandip K Sahu, MS","AIIMS Bhubaneswar","PRINCIPAL_INVESTIGATOR",[38,43],{"name":34,"role":39,"phone":40,"phoneExt":41,"email":42},"CONTACT","+917978243970",null,"ophthal_sandip@aiimsbhubaneswar.edu.in",{"name":44,"role":39,"phone":41,"phoneExt":45,"email":46},"Pavithra S, MBBS","9003134285","pavithras0587@gmail.com",{"type":36,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Sandip Kumar Sahu","Associate Professor","100631712","phase-4-hyaluronic-acid-vs-mitomycin-c-in-external-dacryocystorhinostomy-100631712",false,"NCT07504250","Hyaluronic Acid vs Mitomycin-C in External Dacryocystorhinostomy","Efficacy of Hyaluronic Acid as Intraoperative Adjuvant in External Dacryocystorhinostomy Compared to Mitomycin-C: A Randomized Controlled Trial","HAM-DCR","Inclusion Criteria:\n\n1. All patients within age group 18-65 years diagnosed with chronic dacryocystitis due to Primary Acquired Nasolacrimal Duct Obstruction (PANDO) qualifying for external dacryocystorhinostomy\n2. Patients with resolved acute dacryocystitis\n\nExclusion Criteria:\n\n1. Acute dacryocystitis\u002F Lacrimal sac abscess\n2. Secondary NLDO conditions such as infections, inflammatory, traumatic, malignant, etc.\n3. Failed\u002F recurrent\u002F revision dacryocystorhinostomy and previous dacryocystectomy\n4. Presence of systemic diseases affecting wound healing (eg: uncontrolled diabetes, autoimmune conditions, etc.)\n5. Use of topical or systemic steroids\u002F immunosuppressants within 1 month prior to surgery\n6. Pregnant or lactating women\n7. Known allergy or hypersensitivity to MMC or HA.\n8. Inadequate tear volume for biomarker analysis or poor sample quality.\n9. Intraoperative flap complications\u002F excessive bleeding\n10. Blood stained discharge or bloody regurgitation\n11. Cervical or generalized lymphadenopathy\n12. Dry eyes","ALL","18 Years","65 Years",{"count":62,"type":63},36,"ESTIMATED","INTERVENTIONAL",[66],"PHASE4","RCT to compare the surgical success in patients undergoing external dacryocystorhinostomy with intraoperative Mitomycin-C (0.4 mg\u002Fml) Vs Hyaluronic acid 1% (1ml) as adjuvant, To compare the complication rates and wound healing patterns in each group, To Compare change in tear MMP-9 levels from preoperative (within 1 week before surgery) to postoperative (6 weeks after surgery) , To compare the comfort levels of patients in each group.",[69],"Dacryocystitis",[69,71,72,73],"dacryocystorhinostomy","mitomycin C","hyaluronic acid","NOT_YET_RECRUITING","2026-03-27",{"date":77,"type":78},"2026-03-31","ACTUAL",{"date":80,"type":63},"2026-04-01",{"date":82,"type":63},"2027-12-31",{"name":5,"class":6}]