[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503677":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":25,"locations":26,"responsibleParty":45,"collaborators":25,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":25,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":25,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":25,"overallStatus":29,"whyStopped":25,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Milan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Immediate loading zirconia implant","EXPERIMENTAL","Loading of zirconia dental implant within 7 days after implant placement",[13],"Device: Zirconia implant",{"label":15,"type":16,"description":17,"interventionNames":18},"Delayed loading zirconia implant","ACTIVE_COMPARATOR","Loading of zirconia dental implants after at least 2 months of healing",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Zirconia implant","(Test group; within 7 days of implant placement) versus delayed (Control group; 8 weeks after implant placement)",[15,9],null,[27],{"facility":28,"status":29,"city":30,"state":25,"zip":25,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"San Paolo Hospital","RECRUITING","Milan","Italy","IT",{"type":34,"coordinates":35},"Point",[36,37],12.59836,42.78235,{"lat":37,"lon":36},[40],{"name":41,"role":42,"phone":43,"phoneExt":25,"email":44},"Eugenio Romeo, Full Professor","CONTACT","+39 0250319039","eugenio.romeo@unimi.it",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Antonino Palazzolo","Dr. Principal Investigator","100503677","phase-4-immediate-versus-delayed-loading-of-single-posterior-zirconia-implants-100503677",false,"NCT05838365","Immediate Versus Delayed Loading of Single Posterior Zirconia Implants","Immediate Versus Delayed Loading of Single Posterior Zirconia Implants: A Multicenter Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Sistemically healthy patients\n* partial edentulism\n* premolar position\n* molar position\n* Bone width and height at least 6 and 10mm, respectively.\n* Keratinized tissue, at least 1 mm at implant site\n* Full understanding of the proposed surgical treatments and the protocol schedule\n* Full comprehension and availability to sign the informed consent form\n\nExclusion Criteria:\n\n* Heavy smokers (\\>10 cigarettes a day)\n* Serious kidney or liver diseases\n* Uncontrolled diabetes\n* Bisphosphonates intake\n* History of radiotherapy of the head and neck\n* Current antiblastic chemotherapy\n* Congenital (primary) or acquired (secondary) immunodeficiency\n* Pregnant women\n* Connective tissue disorders\n\nLocal exclusion criteria:\n\n* untreated stage III\u002FIV periodontitis\n* Autoimmune diseases\n* oral parafunctions","ALL","18 Years","80 Years",{"count":60,"type":61},220,"ESTIMATED","INTERVENTIONAL",[64],"PHASE4","The main aim of the present study is to investigate implant success rate after 5 years of function of immediate (Test group; within 7 days of implant placement) versus delayed (Control group; 8 weeks after implant placement) loading of two-pieces zirconia implant, placed in pristine bone without bone regeneration. Implant success rate will be defined according to Buser's criteria. Secondary endpoints: Marginal bone level (MBL) evaluation by means of standardized radiographs; Clinical evaluation of biological (e.g. Plaque Index, PI; Probing Pocket Depth, PPD, Bleeding on Probing, BOP; suppuration upon probing\u002Fpalpation) and prosthetic\u002Ftechnical complications; Clinical evaluation of soft tissue width, keratinized tissue, marginal and interproximal soft tissue recession; Patient reported outcome measures (PROMs) by questionnaire administration:",[67,68,69],"Dental Implant Failed","Peri-implant Mucositis","Peri-Implantitis","2023-04-26",{"date":72,"type":73},"2023-05-01","ACTUAL",{"date":75,"type":73},"2022-12-01",{"date":77,"type":61},"2029-06-01",{"name":5,"class":6},1]