[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570628":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":46,"centralContacts":50,"locations":59,"responsibleParty":77,"collaborators":54,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":54,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":54,"enrollmentInfo":88,"targetDuration":54,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":100,"overallStatus":104,"whyStopped":54,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Walter Reed National Military Medical Center","FED",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Preoperative QL block with liposomal bupivacaine, intra-operative incisional injections with placebo","EXPERIMENTAL","Subjects will receive a pre-operative quadratus lumborum nerve block with liposomal bupivacaine and then an intra-operative placebo injection at each incision site with saline.",[13,14],"Drug: Quadratus Lumborum Block (QLB)","Drug: Local Anesthetic Solution",{"label":16,"type":17,"description":18,"interventionNames":19},"Preoperative QL block with placebo, intra-operative incisional injection with bupivacaine","ACTIVE_COMPARATOR","Subjects will undergo a sham pre-operative quadratus lumborum block procedure with saline and then an intra-operative injection of local anesthetic (0.25% bupivacaine) at each incision site.",[20,14],"Drug: Quadratus lumborum block",[22,29,35,41],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Quadratus Lumborum Block (QLB)","Pre-operative quadratus lumborum block with liposomal bupivacaine",[9],[28],"liposomal bupivacaine",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Quadratus lumborum block","Pre-operative quadratus lumborum block with saline",[16],[34],"saline",{"type":23,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"Local Anesthetic Solution","Intraoperative injection of 0.25% bupivacaine at each incision site",[16],[40],"bupivacaine",{"type":23,"name":36,"description":42,"armGroupLabels":43,"otherNames":44},"Intraoperative injection of saline at each incision site.",[9],[45],"Saline",[47],{"name":48,"affiliation":5,"role":49},"Kathryn A Edmonds, MD","PRINCIPAL_INVESTIGATOR",[51,56],{"name":48,"role":52,"phone":53,"phoneExt":54,"email":55},"CONTACT","301-319-8866",null,"kathryn.a.edmonds2.mil@health.mil",{"name":57,"role":52,"phone":53,"phoneExt":54,"email":58},"Candice E Jones-Cox, MD","candice.e.jones-cox.civ@health.mil",[60],{"facility":5,"status":54,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Bethesda","Maryland","20889","United States","US",{"type":67,"coordinates":68},"Point",[69,70],-77.10026,38.98067,{"lat":70,"lon":69},[73,75,76],{"name":48,"role":52,"phone":74,"phoneExt":54,"email":55},"301-400-2140",{"name":57,"role":52,"phone":53,"phoneExt":54,"email":58},{"name":48,"role":52,"phone":54,"phoneExt":54,"email":54},{"type":78,"investigatorFullName":54,"investigatorTitle":54,"investigatorAffiliation":54,"oldNameTitle":54,"oldOrganization":54},"SPONSOR","100570628","phase-4-impact-of-preoperative-quadratus-lumborum-block-on-postoperative-opioid-consumption-after-laparoscopic-hysterectomy-100570628",false,"NCT06709716","Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy","Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy: a Double-blinded Randomized Controlled Trial","Inclusion Criteria:\n\n* 18 years or older\n* scheduled to undergo laparoscopic hysterectomy\n* able to speak and understand English\n* DEERs eligible (eligible for healthcare within military heath system)\n* Owning a phone that can receive text messages or having internet access to complete questionnaires\n\nExclusion Criteria:\n\n* pre-operative opioid use\n* pre-operative pain management clinic patient\n* planned concomitant prolapse or incontinence procedure\n* planned concomitant non-gynecologic abdominal procedure (i.e. hernia repair)\n* inability to receive liposomal or non-liposomal bupivacaine\n* inability to receive non-steroidal anti-inflammatory drugs (NSAIDs)\n* inability to receive acetaminophen\n* inability to receive oxycodone\n* QL block not able to be performed bilaterally\n* planned or performed mini-laparotomy (incision greater than 2cm)\n* case converted to laparotomy","FEMALE","18 Years",{"count":89,"type":90},76,"ESTIMATED","INTERVENTIONAL",[93],"PHASE4","The goal of this clinical trial is to learn if preoperative nerve block (quadratus lumborum \\[QL\\] block) works to improve pain control during and after laparoscopic hysterectomy. The main questions it aims to answer are:\n\nDoes QL block decrease the amount of narcotic medication needed during surgery? Does QL block decrease the amount of narcotic medication needed after surgery?\n\nResearchers will compare QL block to local injection of a numbing medication at each incision site (the current standard practice) to see if QL block works to decrease surgical pain.\n\nParticipants will be randomly assigned to receive one of the two following interventions:\n\n1. QL block before surgery with a long-acting numbing medicine (liposomal bupivacaine) and then injection of placebo (saline) at each incision site in the operating room.\n2. QL block before surgery with placebo (saline) and then injection of local numbing medicine (bupivacaine) at each incision site in the operating room.\n\nParticipants will also:\n\n* Visit the clinic\u002Fhospital for a pre-operative appointment, the surgical procedure, and a 4-6 week post-operative appointment (all standard visits even if not participating in research)\n* Complete a questionnaire electronically, or by phone, that takes \\\u003C10 minutes at the pre-operative appointment and on postoperative days 1, 3, 5, 14, and 4-6 weeks.",[96,97,98,99],"Postoperative Pain","Laparoscopic Hysterectomy","Nerve Block","Quadratus Lumborum Block",[101,102,103],"postoperative pain","quadratus lumborum block","laparoscopic hysterectomy","NOT_YET_RECRUITING","2024-11-25",{"date":107,"type":108},"2024-11-29","ACTUAL",{"date":110,"type":90},"2024-12-01",{"date":112,"type":90},"2026-02",{"name":5,"class":6},1]