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DNB","9912329342","muralidharnims@gmail.com",{"name":626,"role":34,"phone":18,"phoneExt":18,"email":18},{"facility":631,"status":47,"city":632,"state":633,"zip":634,"country":51,"countryCode":52,"cosmosGeoPoint":635,"geoPoint":639,"contacts":640},"King George's Medical University","Lucknow","Uttar Pradesh","226003",{"type":54,"coordinates":636},[637,638],80.92313,26.83928,{"lat":638,"lon":637},[641,645],{"name":642,"role":37,"phone":643,"phoneExt":18,"email":644},"Parveen K Sharma, MD DM","7388111289","pspgimer@gmail.com",{"name":642,"role":34,"phone":18,"phoneExt":18,"email":18},{"facility":647,"status":47,"city":648,"state":633,"zip":649,"country":51,"countryCode":52,"cosmosGeoPoint":650,"geoPoint":654,"contacts":655},"Institute of Medical Sciences of the Banaras Hindu University (BHU)","Varanasi","221005",{"type":54,"coordinates":651},[652,653],83.01041,25.31668,{"lat":653,"lon":652},[656,660],{"name":657,"role":37,"phone":658,"phoneExt":18,"email":659},"Abhishek Pathak, MD DM","8948512666","abhishekpathakaiims@gmail.com",{"name":657,"role":34,"phone":18,"phoneExt":18,"email":18},{"facility":662,"status":47,"city":663,"state":664,"zip":665,"country":51,"countryCode":52,"cosmosGeoPoint":666,"geoPoint":670,"contacts":671},"Institute of Neurosciences","Kolkata","West Bengal","700017",{"type":54,"coordinates":667},[668,669],88.36304,22.56263,{"lat":669,"lon":668},[672,676],{"name":673,"role":37,"phone":674,"phoneExt":18,"email":675},"Jayanta Roy, MD DM","9903048154","jroyneuro01@gmail.com",{"name":673,"role":34,"phone":18,"phoneExt":18,"email":18},{"facility":678,"status":47,"city":663,"state":664,"zip":679,"country":51,"countryCode":52,"cosmosGeoPoint":680,"geoPoint":682,"contacts":683},"Bangur Institute of Neurosciences","700020",{"type":54,"coordinates":681},[668,669],{"lat":669,"lon":668},[684,688],{"name":685,"role":37,"phone":686,"phoneExt":18,"email":687},"Biman K Ray, MD 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DM","7087009695","dherajk@yahoo.com",{"name":712,"role":34,"phone":18,"phoneExt":18,"email":18},{"facility":717,"status":47,"city":718,"state":18,"zip":719,"country":51,"countryCode":52,"cosmosGeoPoint":720,"geoPoint":724,"contacts":725},"St Stephen's Hospital","Delhi","110054",{"type":54,"coordinates":721},[722,723],77.23149,28.65195,{"lat":723,"lon":722},[726,730],{"name":727,"role":37,"phone":728,"phoneExt":18,"email":729},"Gaurav K Mittal, MD DM","7042877975","drgkmittal@gmail.com",{"name":727,"role":34,"phone":18,"phoneExt":18,"email":18},{"type":34,"investigatorFullName":732,"investigatorTitle":733,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Jeyaraj D Pandian","Principal and Professor, Department of Neurology",[735,738,740,742,744,745,747,750,752,754,756,758,760,762,764,766,768,770,772,774,776,778,780,782,784,786,788,790,792,794,796,798,800,802,804,806,808,810,812,814,816,818,820,822,824,826,828],{"name":736,"class":737},"Indian Council of Medical 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India",{"name":765,"class":749},"CARE Hospitals Hyderabad, India",{"name":767,"class":749},"Lalitha Super Specialities Hospital Guntur, India",{"name":769,"class":749},"Dr. Ramesh Cardiac and Multispeciality Hospital Guntur, India",{"name":771,"class":749},"Government General Hospital Guntur, India",{"name":773,"class":749},"Fortis Escorts Hospital Jaipur, India",{"name":775,"class":6},"Institute of Medical Sciences of the Banaras Hindu University, India",{"name":777,"class":749},"Atal Institute of Medical Super Specilities, (AIMSS) Chamiana, Shimla",{"name":779,"class":6},"All India Institute of Medical Sciences, Bhubaneswar",{"name":781,"class":749},"KLEs Dr. Prabhakar Kore Hospital & Medical Research Centre Balgaum, India",{"name":783,"class":6},"Guru Gobind Singh Medical College & Hospital",{"name":785,"class":749},"PBM Hospital Bikaner, India",{"name":787,"class":749},"Shree Krishna Hospital Pramukhswami Medical College Anand, India",{"name":789,"class":749},"Apollo Excelcare Hospitals Guwahati, India",{"name":791,"class":749},"Manipal Hospital Bangalore, India",{"name":793,"class":749},"Artemis Hospital Gurgaon, India",{"name":795,"class":749},"Dr. Kamakshi Memorial Hospital Chennai, India",{"name":797,"class":749},"Bharati Vidyapeeth DTU Medical College Pune, India",{"name":799,"class":749},"Aster MIMS Hospital Calicut, India",{"name":801,"class":749},"Holy Spirit Hospital Mumbai, India",{"name":803,"class":749},"Sparsh Superspeciality Hospital Bangalore, India",{"name":805,"class":749},"King George's Medical University, Lucknow, India",{"name":807,"class":749},"Assam Medical College, Dibrugarh, India",{"name":809,"class":749},"KG Hospital and Post Graduate Medical Institute Coimbatore, India",{"name":811,"class":749},"Tirunelveli Medical College, Tirunelveli, India",{"name":813,"class":749},"Santokba Durlabhji Memorial Hospital, Jaipur, India",{"name":815,"class":749},"Tezpur Medical College and Hospital, Assam, India",{"name":817,"class":749},"Baby Memorial Hospital Calicut, India",{"name":819,"class":749},"Institute of Human Behaviour and Allied Sciences Delhi, India",{"name":821,"class":749},"The Calcutta Medical Research Institute, Kolkata, India",{"name":823,"class":749},"Fortis Hospital Mulund Mumbai, India",{"name":825,"class":749},"Government Medical College Trivandrum, India",{"name":827,"class":749},"Ruby Hall Clinic, Pune, India",{"name":829,"class":749},"Manipal Hospital Goa, India","100503559","phase-4-indian-trial-of-tranexamic-acid-in-spontaneous-intracerebral-haemorrhage-100503559",false,"NCT05836831","Indian Trial of Tranexamic Acid in Spontaneous Intracerebral Haemorrhage","Inclusion Criteria:\n\nAdult patients aged more than 18 years, presenting with non- traumatic intracerebral haemorrhage within 4.5 hours of onset of stroke symptoms\n\nExclusion Criteria:\n\n1. Patients with ICH secondary to anticoagulation, thrombolysis, or known underlying structural abnormality such as arteriovenous malformation, aneurysm, tumor, venous thrombosis or due to known hereditary coagulation disorders.\n2. Contraindication to TXA.\n3. Concurrent participation in another trial.\n4. Pre-stroke life expectancy \\\u003C3 months (e.g. advanced metastatic cancer).\n5. Glasgow coma scale (GCS) ⩽5.\n6. ICH secondary to trauma.\n7. Women of childbearing potential, pregnant, or breastfeeding at randomization.\n8. Geographical or other factors that prohibit follow-upto 90 days.\n9. Concurrent or planned treatment with any other hemostatic agents.\n10. ICH volume \\>60 mL as measured by ABC\u002F2 method.","ALL","18 Years","99 Years",{"count":840,"type":841},3400,"ESTIMATED","INTERVENTIONAL",[844],"PHASE4","This multicenter, pragmatic randomized, open-label clinical trial aims to assess whether Tranexamic Acid improves outcomes in adult patients with spontaneous intracerebral haemorrhage.\n\nThe participants presenting within 4.5 hours of the onset of symptoms of stroke with intracerebral haemorrhage confirmed on Computed Tomography (CT Scan) will be randomized into two groups in a 1:1 ratio using a central online randomization. The treatment arm will consist of giving intravenously 2 grams of Tranexamic Acid in 100 ml 0.9% sodium chloride administered over 45 minutes. Control arm patients will receive standard of care treatment as per the institutional protocol. In both arms, intensive systolic blood pressure reduction to less than 140 mmHg will be done using antihypertensive medications, which has to be achieved within one hour and will be maintained over next seven days. The choice of antihypertensive drug will depend on the clinician's preference.\n\nBoth groups will have a repeat CT scan after 24 hours to check for any increase in the haematoma volume. Any deterioration in the neurological status will warrant urgent brain imaging. On day 7, the patient will be assessed for their NIHSS score and mRS score. On day 90, quality of life and the functional outcome will be assessed.",[847],"Intracerebral Hemorrhagic Stroke",[849,850,851],"Stroke","Spontaneous Intracerebral Haemorrhage","Tranexamic acid","2026-01-21",{"date":854,"type":855},"2026-01-22","ACTUAL",{"date":857,"type":855},"2022-08-30",{"date":859,"type":841},"2026-11",{"name":5,"class":6},48]