[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571465":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":48,"responsibleParty":113,"collaborators":42,"id":116,"slug":117,"hasResults":118,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":118,"sex":124,"minAge":125,"maxAge":42,"enrollmentInfo":126,"targetDuration":42,"studyType":129,"phases":130,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":140,"whyStopped":42,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},{"fullName":5,"class":6},"Indonesia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Vonoprazan","EXPERIMENTAL","Each randomized patients will consume 20mg of vonoprazan once a day for 14 days consecutively",[13],"Drug: Vonoprazan 20 mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Esomeprazole","ACTIVE_COMPARATOR","Each randomized patients will consume 40mg of esomeprazole once a day for 14 days consecutively",[19],"Drug: Esomeprazole",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Vonoprazan 20 mg","Vonoprazan PO, 20mg, once a day, 14 days.",[9],[27],"vocinti",{"type":22,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"Esomeprazole PO, 40mg, once a day, 14 days",[15],[32],"Esomeprazole generic",[34],{"name":35,"affiliation":36,"role":37},"Ari F Syam, MD","Fakultas Kedokteran Universitas Indonesia","PRINCIPAL_INVESTIGATOR",[39,44],{"name":35,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","+62818706199",null,"ari_syam@hotmail.com",{"name":45,"role":40,"phone":46,"phoneExt":42,"email":47},"Ryan Herardi, MD","+6281381166910","dr.ryanherardi@gmail.com",[49,61,73,84,99],{"facility":50,"status":42,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":42,"geoPoint":42,"contacts":56},"Hermina Jatinegara Hospital","East Jakarta","DKI Jakarta","13320","Indonesia","ID",[57],{"name":58,"role":40,"phone":59,"phoneExt":42,"email":60},"Arlyando Saragih, MD","+628128225640","arlyando2020@gmail.com",{"facility":62,"status":42,"city":63,"state":52,"zip":64,"country":54,"countryCode":55,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Cipto Mangunkusumo Hospital","Jakarta Pusat","10430",{"type":66,"coordinates":67},"Point",[68,69],106.8223,-6.1818,{"lat":69,"lon":68},[72],{"name":45,"role":40,"phone":46,"phoneExt":42,"email":47},{"facility":74,"status":42,"city":63,"state":52,"zip":75,"country":54,"countryCode":55,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},"Hermina Kemayoran Hospital","10620",{"type":66,"coordinates":77},[68,69],{"lat":69,"lon":68},[80],{"name":81,"role":40,"phone":82,"phoneExt":42,"email":83},"Andry Kurniawan, MD","+628126729703","andreedoc85@gmail.com",{"facility":85,"status":42,"city":86,"state":87,"zip":88,"country":54,"countryCode":55,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Hermina Bekasi Hospital","Bekasi","West Java","17141",{"type":66,"coordinates":90},[91,92],106.9896,-6.2349,{"lat":92,"lon":91},[95],{"name":96,"role":40,"phone":97,"phoneExt":42,"email":98},"Nikko Darnindro, MD","+628129734458","nikkodarnindro@gmail.com",{"facility":100,"status":42,"city":101,"state":87,"zip":102,"country":54,"countryCode":55,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Hermina Depok Hospital","Depok","16436",{"type":66,"coordinates":104},[105,106],106.81861,-6.4,{"lat":106,"lon":105},[109],{"name":110,"role":40,"phone":111,"phoneExt":42,"email":112},"Aru Ariadno, MD","+6281384473476","roeariadno@gmail.com",{"type":37,"investigatorFullName":114,"investigatorTitle":115,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Ari Fahrial Syam","Dean of Faculty of Medicine Universitas Indonesia","100571465","phase-4-indonesian-study-of-vonoprazan-vs-esomeprazole-in-erosive-esophagitis-100571465",false,"NCT06720610","Indonesian Study of Vonoprazan Vs Esomeprazole in Erosive Esophagitis","Comparison of the Effectiveness of Vonoprazan and Esomeprazole in Improving Initial Symptoms in Patients with Erosive Esophagitis: a Double-Blind Randomized Trial","INVEST","Inclusion Criteria:\n\n* Patients aged \\>18 years with a GERD-Q score of 8.\n* Diagnosed with erosive esophagitis by endoscopy. (Los Angeles Classification A-D)\n* Patients are willing to undergo a series of therapeutic management.\n\nExclusion Criteria:\n\n* Patients with a history of allergy to PCAB or PPI groups.\n* Patients with gastric and\u002For duodenal ulcers.\n* Patients with Helicobacter pylori infection.\n* Patients with a history of significant systemic disease disorders affecting the esophagus and stomach.\n* Patients with a history of malignant disease related to the esophagus and\u002For stomach.\n* Patients with a history of esophageal and\u002For gastric surgery.\n* Pregnant patients","ALL","18 Years",{"count":127,"type":128},216,"ESTIMATED","INTERVENTIONAL",[131],"PHASE4","The goal of this clinical trial is to compare drug vonoprazan vs esomeprazole effectiveness to relieve early symptoms in Erosive Esophagitis Patients. It will also learn about the safety of both modalities. The main questions it aims to answer are:\n\nHow does the effectiveness of Vonoprazan compare with Esomeprazole in improving early symptoms of erosive esophagitis patients in the Indonesian population?\n\nResearchers will compare drug vonoprazan to a esomeprazole with a look-alike packaging to see their effect to reduce early symptoms of erosive esophagitis.\n\nParticipants will:\n\n* Take drug vonoprazan 20mg or esomeprazole 40mg one time every day for 2 weeks\n* Visit the clinic once every weeks for followup (Gastro Esophageal Reflux Disease-Quetionnaire measurement)\n* Keep a diary of their adverse effect occurence and every variable data based on Gastro Esophageal Reflux Disease-Questionnaire.",[134],"Erosive Esophagitis",[136,137,138,139],"erosive esophagitis","vonoprazan","esomeprazole","gerd-q","NOT_YET_RECRUITING","2024-12-12",{"date":143,"type":144},"2024-12-17","ACTUAL",{"date":146,"type":128},"2024-12-09",{"date":148,"type":128},"2025-06-27",{"name":5,"class":6},5]