[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640947":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":49,"locations":53,"responsibleParty":55,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":53,"enrollmentInfo":70,"targetDuration":53,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":53,"overallStatus":80,"whyStopped":53,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":53},{"fullName":5,"class":6},"University of Aarhus","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous infusion preceded by a loading dose","EXPERIMENTAL","Participants receive intravenous furosemide administered as a continuous infusion preceded by an initial loading dose. The loading dose is administered immediately before initiation of the infusion. Daily intravenous furosemide doses are determined according to the participant's oral loop diuretic dose at hospital admission using a predefined dosing algorithm.",[13],"Drug: Intravenous furosemide continuous infusion",{"label":15,"type":10,"description":16,"interventionNames":17},"Bolus injections three times a day","Participants receive intravenous furosemide administered as bolus injections three times a day. The first bolus injection includes an additional dose to mirror the loading dose strategy used in the continuous infusion group. Daily intravenous furosemide doses are determined according to the participant's oral loop diuretic dose at hospital admission using a predefined dosing algorithm.",[18],"Drug: Intravenous furosemide bolus injections",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Intravenous furosemide continuous infusion","Intravenous furosemide administered as a continuous infusion preceded by a loading dose. Daily intravenous furosemide doses are determined according to the participant's oral loop diuretic dose at hospital admission using a predefined dosing algorithm.",[9],[26],"Furosemide infusion",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Intravenous furosemide bolus injections","Intravenous furosemide administered as bolus injections three times a day. The first bolus injection includes an additional dose to mirror the loading dose strategy used in the continuous infusion group. Daily intravenous furosemide doses are determined according to the participant's oral loop diuretic dose at hospital admission using a predefined dosing algorithm.",[15],[32],"Furosemide bolus injections",[34,38,41,44,46],{"name":35,"affiliation":36,"role":37},"Esben Merrild, MD","Department of Medicine, Randers Regional Hospital","STUDY_DIRECTOR",{"name":39,"affiliation":36,"role":40},"Bo Løfgren, MD PhD","STUDY_CHAIR",{"name":42,"affiliation":43,"role":40},"Henrik Birn, MD PhD DMSc","Department of Renal Medicine, Aarhus University Hospital",{"name":45,"affiliation":36,"role":40},"Kasper G Lauridsen, MD PhD",{"name":47,"affiliation":48,"role":40},"Christian B Poulsen, MD PhD","Private Organization",[50],{"name":35,"role":51,"phone":52,"phoneExt":53,"email":54},"CONTACT","+4522996026",null,"esbenmerrild@clin.au.dk",{"type":56,"investigatorFullName":53,"investigatorTitle":53,"investigatorAffiliation":53,"oldNameTitle":53,"oldOrganization":53},"SPONSOR",[58],{"name":59,"class":6},"Central Denmark Region","100640947","phase-4-infusion-of-furosemide-to-improve-diuretic-efficiency-in-acute-heart-failure-100640947",false,"NCT07577596","Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure","Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure (INFUSE-AHF)","INFUSE-AHF","Inclusion Criteria:\n\n* Clinical diagnosis of acute heart failure with volume overload\n* At least 1 sign of volume overload\n* Anticipated intravenous furosemide treatment for at least 3 days\n* Age 18 years or older\n\nExclusion Criteria:\n\n* Shock\n* Patient requiring treatment with inotropes or vasopressors\n* Current or planned use of renal replacement therapy or ultrafiltration\n* Patient with a renal transplant\n* Patients who are pregnant or breastfeeding\n* Severe hypokalaemia, defined as potassium less than 2.5 mmol\u002FL, or severe hyponatremia, defined as sodium less than 125 mmol\u002FL\n* Allergy to furosemide and its components","ALL","18 Years",{"count":71,"type":72},436,"ESTIMATED","INTERVENTIONAL",[75],"PHASE4","Acute heart failure is a condition where the heart suddenly cannot pump blood well enough for the body's needs. Many people admitted to the hospital with acute heart failure have too much fluid in the body. This can cause shortness of breath, swelling, and the need for treatment with water-removing medicine.\n\nFurosemide is a commonly used water-removing medicine that is given into a vein to treat fluid overload. It can be given in different ways. One way is as a continuous infusion, where the medicine is given slowly over time through a pump. Another way is as repeated injections given several times a day. It is not known whether one of these ways is better than the other for removing excess fluid in people with acute heart failure.\n\nThe purpose of this study is to compare two ways of giving furosemide into a vein: Continuous infusion started with an initial extra dose, and bolus injections given three times a day. About 436 adults admitted to hospitals in Denmark with acute heart failure and fluid overload will take part. Participants will be randomly assigned to one of the two treatment groups. This means that chance will decide which treatment method each participant receives.\n\nThe main thing the researchers will measure is how much body weight participants lose about 3 days after randomization. Weight loss is used as a measure of how much excess fluid has been removed.",[78,79],"Acute Heart Failure","Volume Overload","NOT_YET_RECRUITING","2026-05-05",{"date":83,"type":84},"2026-05-11","ACTUAL",{"date":86,"type":72},"2026-05-01",{"date":88,"type":72},"2027-10-01",{"name":5,"class":6}]