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Adult patients receiving mechanical ventilation, with an anticipated duration \\>48 hours after randomization, and requiring deep sedation (target RASS between -3 and -5).\n\nExclusion Criteria:\n\n* Contraindication to isoflurane or propofol\n* Patients with maternal ancestry from Venezuela, due to the potential presence of an mt-ND4 gene mutation associated with neurological injury after exposure to certain volatile anaesthetic agents\n* Significant air leak, defined as a leak exceeding 30% of the delivered minute ventilation\n* Allergy to isoflurane or propofol\n* Cardiopulmonary arrest\n* History of ventricular tachycardia or long QT syndrome\n* Tidal volume \\\u003C 300 mL or PaCO₂ \\> 50 mmHg at the time of randomization.\n* Invasive mechanical ventilation for more than 48 hours at the time of randomization.\n* Pregnancy\n* Breast feeding\n* Acute neurological condition\n* Patients expected to require repeated surgical interventions during their ICU stay.\n* ECMO\n* ECCO2R\n* Active humidification strictly required\n* Neuromuscular disease or high spinal cord injury likely to prevent discontinuation of mechanical ventilation due to baseline condition\n* Requirement for benzodiazepine use for a specific indication\n* Burns\n* Life expectancy less than 48 hours, or patients with such a level of severity that death during the ICU stay is considered highly likely.\n* Any condition (e.g., blindness, deafness, dementia) or language barrier that prevents the administration of delirium or cognitive assessment scales.\n* Lack of informed consent","ALL","18 Years","80 Years",{"count":346,"type":347},620,"ESTIMATED","INTERVENTIONAL",[350],"PHASE4","The proposal of this study is to compare inhaled sedation with isoflurane administered via the Sedaconda ACD-S system with intravenous sedation with propofol. Patients will be randomized 1:1 to receive either inhaled sedation with isoflurane administered via the Sedaconda ACD device (Sedana Medical, Uppsala, Sweden) or intravenous propofol. The primary endpoint is the number of ventilator-free days at 28 days after randomization.",[353,354],"Sedation","Airway Extubation",[356,357,358],"Inhaled sedation","Mechanical ventilation","Delirium","2026-06-26",{"date":361,"type":362},"2026-06-29","ACTUAL",{"date":364,"type":362},"2025-12-15",{"date":366,"type":347},"2027-12",{"name":5,"class":6},22]