[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631955":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":31,"centralContacts":31,"locations":31,"responsibleParty":32,"collaborators":34,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":31,"eligibilityCriteria":43,"healthyVolunteers":40,"sex":44,"minAge":45,"maxAge":31,"enrollmentInfo":46,"targetDuration":31,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":58,"overallStatus":64,"whyStopped":31,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":31},{"fullName":5,"class":6},"Unity Health Toronto","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"STRATAFIX™ and DERMABOND™ PRINEO™ Intervention Group","EXPERIMENTAL","This experimental arm evaluates a dual-component sternal closure strategy in 401 patients undergoing CABG surgery. The intervention replaces traditional non-barbed sutures with a combination of STRATAFIX™ barbed sutures and DERMABOND™ PRINEO™ mesh-based adhesive.",[13,14],"Device: Knotless Barbed Sutures","Device: Mesh-based Topical Skin Adhesive",[16,25],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DEVICE","Knotless Barbed Sutures","This intervention replaces traditional non-barbed, knotted sutures with a specialized knotless and adhesive system. The strategy is characterized by the following layer-specific applications:\n\nDeep Tissue (Presternal Fascia): Application of STRATAFIX™ Symmetric barbed sutures.\n\nSubcutaneous and Subcuticular Layers: Use of STRATAFIX™ Spiral MONOCRYL™ Plus and\u002For STRATAFIX™ Spiral PDS™ Plus. These sutures feature an antibacterial triclosan coating designed to reduce the risk of surgical site infections.",[9],[22,23,24],"STRATAFIX™ Symmetric barbed sutures","STRATAFIX™ Spiral MONOCRYL™ Plus","STRATAFIX™ Spiral PDS™ Plus",{"type":17,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Mesh-based Topical Skin Adhesive","Skin Surface: Final closure using the DERMABOND™ PRINEO™ system, which combines 2-octyl cyanoacrylate topical adhesive with a self-adhesive polymer mesh tape.",[9],[30],"DERMABOND™ PRINEO™",null,{"type":33,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR",[35],{"name":36,"class":37},"Johnson & Johnson","INDUSTRY","100631955","phase-4-innovative-sternal-closure-techniques-evaluating-stratafix-and-dermabond-for-reduced-complications-in-cabg-patients-100631955",false,"NCT07507409","Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients","Inclusion Criteria:\n\n\\- Patients aged 18 years and older undergoing CABG surgery.\n\nExclusion Criteria:\n\n* Patients who refuse to participate in the trial.\n* Patients who do not read or speak English.\n* Patient with allergy to surgical adhesives or sutures","ALL","18 Years",{"count":47,"type":48},401,"ESTIMATED","INTERVENTIONAL",[51],"PHASE4","The goal of this clinical trial is to learn if a new method of closing the breastbone after heart bypass surgery can improve healing and reduce complications in adults undergoing coronary artery bypass graft (CABG) surgery.\n\nThe main questions it aims to answer are:\n\nDoes this new closure method reduce infections and wound reopening? Does it improve healing, recovery, and overall patient outcomes?\n\nResearchers will compare patients who receive the new closure method to past patients who received the standard method to see if outcomes are better.\n\nParticipants will:\n\nReceive the new closure method during their surgery (as part of standard care) Be followed during their normal recovery up to their 6-week follow-up visit Complete a short quality-of-life questionnaire (about 10 minutes) Have their recovery assessed, including healing, complications, and hospital use\n\nResearchers will also look at quality of life, heart complications, hospital readmissions, antibiotic use, scar appearance, and overall costs to understand the full impact of the new method.",[54,55,56,57],"Cardiovascular Disease","Surgical Site Infection","Superficial Sternal Wound Infection","Mediastinitis",[59,60,61,62,63],"STRATAFIX","DERMABOND","Sternal Closure","Suture","CABG","NOT_YET_RECRUITING","2026-04-07",{"date":67,"type":68},"2026-04-13","ACTUAL",{"date":70,"type":48},"2026-05-01",{"date":72,"type":48},"2028-05-01",{"name":5,"class":6}]