[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555372":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":57,"collaborators":18,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":18,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":18,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":18,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"The Methodist Hospital Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intraosseous Injection of Morphine","EXPERIMENTAL","The intervention group will receive an intraosseous (IO) injection of 10mg of morphine mixed with up to 100mg of saline into the tibial tubercle during a standard ACL reconstruction.",[13],"Drug: Intraosseous Morphine",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of Care Morphine Administration","NO_INTERVENTION","The control group will receive the standard of care treatment, which is no IO injection during a standard ACL reconstruction.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Intraosseous Morphine","More recently, intraosseous infusion of analgesics and antibiotics has gained traction in the total joint arthroplasty literature. In knee arthroplasty patients, the combination of a spine and adductor canal block with an intraosseous infusion of morphine into the tibial tubercle prior to incision yielded lower pain in the immediate postoperative period and at 2 weeks, less pain medication use, and significantly better patient-reported outcomes while also reducing systemic opioid exposure in the early postoperative period compared to the spine and adductor block alone.3 No study to date in the available literature has evaluated the efficacy of intraosseous morphine infusion in managing acute postoperative pain in patients undergoing ACL reconstruction with bone-patellar tendon-bone autograft, so that is the intended evaluation point with this project.",[9],[26,27,28],"Duramorph","Astramorph PF","Infumorph",[30],{"name":31,"affiliation":5,"role":32},"Robert Jack, MD","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":18,"email":38},"Haley Goble, MHA","CONTACT","713-441-3930","hmgoble@houstonmethodist.org",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Houston Methodist Research Institute","RECRUITING","Houston","Texas","77030","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-95.36327,29.76328,{"lat":52,"lon":51},[55],{"name":56,"role":36,"phone":18,"phoneExt":18,"email":18},"Haley Goble",{"type":32,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Robert A. Jack","Assistant Professor of Clinical Orthopedic Surgery, Academic Institute","100555372","phase-4-intraosseous-morphine-administration-during-anterior-cruciate-ligament-reconstruction-100555372",false,"NCT06511232","Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction","Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction: A Randomized Control Trial","Inclusion Criteria:\n\n* Patients of the IRB approved surgeon(s) undergoing ACL reconstruction with bone-to-bone (BTB) autograft\n* Patients aged between 18-40 years old at the time of surgery\n\nExclusion Criteria:\n\n* Patients undergoing ACL reconstruction with any other type of autograft or allograft other than BTB\n* Patients younger than 18 years old or older than 40 years old\n* Patients undergoing meniscal root repair or any other repair that changes their weight-bearing status\n* Patients with a history of substance abuse\n* Vulnerable populations\n* Patients on chronic pain medication within the last 6 months\n* BMI \\>\u002F= 35\n* Allergy to morphine\n* Unwilling to participate\n* Any additional reason the PI deems reasonable","ALL","18 Years","40 Years",{"count":71,"type":72},84,"ESTIMATED","INTERVENTIONAL",[75],"PHASE4","The purpose of this study is to determine if intraosseous (IO) morphine decreases pain and post-operative opioid use in patients undergoing anterior cruciate ligament (ACL) reconstruction.",[78,79,80],"Anterior Cruciate Ligament Tear","Anterior Cruciate Ligament Injuries","Anterior Cruciate Ligament Rupture","2026-04-07",{"date":83,"type":84},"2026-04-09","ACTUAL",{"date":86,"type":84},"2024-08-19",{"date":88,"type":72},"2029-07-31",{"name":5,"class":6},1]