[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100466246":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":38,"responsibleParty":58,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":26,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":26,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Northwestern University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","Placebo, Intrathecal saline",[13],"Other: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Morphine","ACTIVE_COMPARATOR","Intrathecal morphine",[19],"Drug: Morphine Sulfate",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Morphine Sulfate","5 mcg\u002Fkg intrathecal preservative free morphine sulfate",[15],null,{"type":6,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"Sterile saline, placebo",[9],[31],"Sterile Saline",[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Richa Dhawan, MD MPH","CONTACT","312-695-0061","richa.dhawan@northwestern.edu",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"University of Chicago","RECRUITING","Chicago","Illinois","60637","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-87.65005,41.85003,{"lat":51,"lon":50},[54],{"name":55,"role":35,"phone":56,"phoneExt":26,"email":57},"Ed Fox","773-834-5234","efox1@bsd.uchicago.edu",{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Richa Dhawan","Associate Professor","100466246","phase-4-intrathecal-morphine-for-analgesia-in-video-assisted-and-robotic-assisted-thoracic-surgery-100466246",false,"NCT05351229","Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery","Intrathecal Morphine for Postoperative Analgesia in Video-Assisted and Robotic-Assisted Thoracic Surgery: A Randomized, Placebo-controlled, Double-blinded Clinical Trial","Inclusion Criteria:\n\n* Age 18-80 years old\n* Undergoing elective video-assisted thoracoscopic or robotic assisted surgery for anatomical lung resection\n* General anesthesia with anticipated intraoperative extubation.\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) classification of 4 or 5\n* Anticipated postoperative intubation\n* Significant liver disease\n* Preoperative use of intravenous inotropes and\u002For vasopressor support\n* Preoperative mechanical ventilation\n* Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)\n* Severe pulmonary disease (home oxygen requirement and\u002For current oral steroid use)\n* Morphine allergy\n* Opioid or alcohol abuse\n* Chronic pain\n* Renal failure\n* Inability to comprehend English language\n* Bleeding disorder\n* Abnormal preoperative coagulation\n* Infection\n* Patient refusal\n* Failed spinal","ALL","18 Years","80 Years",{"count":73,"type":74},90,"ESTIMATED","INTERVENTIONAL",[77],"PHASE4","VATS\u002FRATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS\u002FRATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investigation, investigators hypothesize that 5 mcg\u002Fkg intrathecal morphine will decrease postoperative analgesic consumption and reduce pain.",[80],"Pain, Postoperative","2026-06-05",{"date":83,"type":84},"2026-06-09","ACTUAL",{"date":86,"type":84},"2023-09-29",{"date":88,"type":74},"2027-09-01",{"name":5,"class":6},1]