[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622648":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":24,"locations":28,"responsibleParty":51,"collaborators":24,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":24,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":24,"enrollmentInfo":63,"targetDuration":24,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":76,"overallStatus":30,"whyStopped":24,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Hospital Central do Funchal","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intrathecal morphine","EXPERIMENTAL","Postoperative analgesia with intrathecal morphine 80 mcg",[13],"Drug: Intrathecal Morphine",{"label":15,"type":10,"description":16,"interventionNames":17},"Epidural morphine","Postoperative analgesia with epidural morphine 2.5mg",[18],"Drug: Epidural Morphine",[20,25],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":24},"DRUG","Intrathecal Morphine",[9],null,{"type":21,"name":26,"description":16,"armGroupLabels":27,"otherNames":24},"Epidural Morphine",[15],[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Funchal","Madeira","9004-514","Portugal","PT",{"type":37,"coordinates":38},"Point",[39,40],-16.92547,32.66568,{"lat":40,"lon":39},[43,48],{"name":44,"role":45,"phone":46,"phoneExt":24,"email":47},"Joao Salgado Costa","CONTACT","+351914633659","joaomscosta1@gmail.com",{"name":49,"role":50,"phone":24,"phoneExt":24,"email":24},"João Salgado Costa","PRINCIPAL_INVESTIGATOR",{"type":50,"investigatorFullName":44,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Anesthesiology Resident","100622648","phase-4-intrathecal-versus-epidural-morphine-for-post-cesarean-analgesia-100622648",false,"NCT07386353","Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia","Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women scheduled for elective cesarean section;\n* Age \\> 18 years;\n* Willingness to participate in the study, as demonstrated by signed informed consent.\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status classification \\> III;\n* Chronic kidney disease with a glomerular filtration rate \\\u003C 60 mL\u002Fmin;\n* Relevant drug allergies (particularly to protocol medications);\n* Opioid tolerance;\n* Contraindication to neuraxial anesthetic techniques.",true,"FEMALE","18 Years",{"count":64,"type":65},120,"ESTIMATED","INTERVENTIONAL",[68],"PHASE4","Cesarean section is one of the most commonly performed surgical procedures worldwide, making effective management of acute postoperative pain a key issue in obstetric anesthesiology. Post-cesarean analgesia should promote rapid maternal recovery, support newborn care, and consider the pharmacological implications for breastfeeding.\n\nAccording to recent PROSPECT® guidelines from ESRA, neuraxial opioids play a central role in post-cesarean analgesia and are at least as effective as other techniques, such as continuous local anesthetic infusion. However, the optimal route of opioid administration remains unclear. While earlier studies favored epidural morphine, more recent evidence suggests that intrathecal morphine may provide superior analgesia. Due to limited and conflicting data, no definitive conclusion can be drawn. Given that epidural morphine remains standard practice at Hospital Central do Funchal, a randomized clinical trial is proposed to compare the analgesic efficacy of intrathecal versus epidural morphine after elective cesarean section.",[71,72,73,74,75],"Analgesia Obstetrical","Analgesia","Post Operative Pain","Patient Satisfaction","Cesarean Section Pain",[77,26,22],"Post-Cesarean Analgesia","2026-01-27",{"date":80,"type":81},"2026-02-04","ACTUAL",{"date":83,"type":81},"2024-05-20",{"date":85,"type":65},"2026-07-31",{"name":5,"class":6},1]