[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053446":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":36,"locations":45,"responsibleParty":60,"collaborators":27,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":27,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":27,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":86,"overallStatus":101,"whyStopped":27,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Seoul National University Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Single-shot block with IV dexamethasone","EXPERIMENTAL","Participants receive a single-shot ultrasound-guided interscalene brachial plexus block with 0.75% ropivacaine 15-20 mL, followed by intravenous dexamethasone 5 mg administered after confirmation of successful block on arrival in the operating room. Postoperatively, an intravenous patient-controlled analgesia (PCA) pump with fentanyl (10 mcg\u002FmL, bolus 1 mL, lockout 6 min, no basal rate) is connected. All participants receive standard multimodal analgesia (intravenous acetaminophen 1000 mg plus ibuprofen 300 mg every 8 hours).",[13,14],"Drug: Dexamethasone (IV)","Procedure: Single-shot interscalene brachial plexus block",{"label":16,"type":17,"description":18,"interventionNames":19},"Continuous interscalene brachial plexus block","ACTIVE_COMPARATOR","Participants receive an ultrasound-guided continuous interscalene brachial plexus block: 0.75% ropivacaine 15-20 mL is injected at the interscalene level, and a perineural catheter is placed with the tip adjacent to the superior trunk. Postoperatively, a nerve block PCA (0.2% ropivacaine, basal rate 5 mL\u002Fh, bolus 3 mL, lockout 30 min) is connected via the catheter. All participants receive the same standard multimodal analgesia as the experimental arm.",[20],"Procedure: Continuous interscalene brachial plexus block",[22,28,33],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Dexamethasone (IV)","Intravenous dexamethasone 5 mg, administered as a single dose after confirmation of adequate sensory and motor block on arrival in the operating room.",[9],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"PROCEDURE","Single-shot interscalene brachial plexus block","Ultrasound-guided single-shot interscalene brachial plexus block performed with a 50 mm needle. 0.75% ropivacaine 15-20 mL is injected at the interscalene level. No perineural catheter is placed.",[9],{"type":29,"name":16,"description":34,"armGroupLabels":35,"otherNames":27},"Ultrasound-guided interscalene brachial plexus block with 0.75% ropivacaine 15-20 mL, followed by placement of a perineural catheter adjacent to the superior trunk. Continuous postoperative analgesia is provided through the catheter using 0.2% ropivacaine (basal rate 5 mL\u002Fh, bolus 3 mL, lockout time 30 min) via a patient-controlled analgesia pump.",[16],[37,42],{"name":38,"role":39,"phone":40,"phoneExt":27,"email":41},"Hansol Kim, M.D.","CONTACT","+82-2-2072-2467","hansolfrkr@gmail.com",{"name":43,"role":39,"phone":40,"phoneExt":27,"email":44},"Hwan Suk Jang, M.D.","j4n6h5@gmail.com",[46],{"facility":5,"status":27,"city":47,"state":48,"zip":49,"country":50,"countryCode":27,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Seoul","Jongno-gu","03080","South Korea",{"type":52,"coordinates":53},"Point",[54,55],126.9784,37.566,{"lat":55,"lon":54},[58,59],{"name":38,"role":39,"phone":40,"phoneExt":27,"email":41},{"name":43,"role":39,"phone":40,"phoneExt":27,"email":44},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Hansol Kim, MD","Clinical Associate Professor","100053446","phase-4-intravenous-dexamethasone-with-single-shot-versus-continuous-brachial-plexus-block-for-rebound-pain-after-shoulder-surgery-100053446",false,"NCT07699744","Intravenous Dexamethasone With Single-Shot Versus Continuous Brachial Plexus Block for Rebound Pain After Shoulder Surgery","Pain Management Protocol Optimization for Rebound Pain Prevention and Enhanced Recovery After Shoulder Surgery: A Randomized Noninferiority Trial of Intravenous Dexamethasone Combined With Single-Shot Versus Continuous Brachial Plexus Block","Inclusion Criteria:\n\n* Adult patients aged 19 to 79 years scheduled for elective shoulder surgery under brachial plexus block and monitored anesthesia care (MAC)\n\nExclusion Criteria:\n\n* Pre-existing neurological deficit of the brachial plexus\n* Emergency surgery\n* American Society of Anesthesiologists (ASA) physical status classification IV or higher\n* Contraindication or history of hypersensitivity to local anesthetics or dexamethasone\n* Severe pulmonary disease (e.g., chronic obstructive pulmonary disease)\n* Body mass index (BMI) ≥ 35 kg\u002Fm²\n* Long-term use of steroids\n* Long-term use of analgesics\n* Inability to cooperate or communicate\n* Pregnancy","ALL","19 Years","79 Years",{"count":75,"type":76},92,"ESTIMATED","INTERVENTIONAL",[79],"PHASE4","Shoulder surgery often causes severe pain after the operation. To control this pain, doctors commonly perform a nerve block (interscalene brachial plexus block), which numbs the shoulder area. However, when the effect of a single-injection nerve block wears off, many patients experience sudden, intense pain known as \"rebound pain\".\n\nOne way to prevent rebound pain is to place a thin catheter near the nerves so that local anesthetic can be given continuously for a longer period (continuous nerve block). However, this method is technically demanding and can cause problems such as catheter dislodgement, infection, and inconvenience for patients. Another simpler option is to give a single-injection nerve block together with an intravenous (IV) injection of dexamethasone, a steroid medication known to prolong the effect of nerve blocks and reduce rebound pain.\n\nThe purpose of this study is to determine whether a single-injection nerve block combined with IV dexamethasone (5 mg) is not inferior to a continuous nerve block in preventing rebound pain after shoulder surgery. A total of 92 adult patients scheduled for elective shoulder surgery will be randomly assigned to one of the two groups. The main outcome is the rebound pain score, defined as the difference between the last pain score recorded in the recovery room (while the nerve block is still working) and the highest pain score reported within the first 24 hours after the nerve block. The investigators expect that the simpler single-injection method with IV dexamethasone will provide comparable pain control while avoiding the complications and inconvenience of catheter-based continuous nerve blocks.",[82,83,84,85],"Pain, Postoperative","Rebound Pain","Shoulder Injuries","Rotator Cuff Injuries",[87,88,89,90,91,92,93,94,95,96,97,98,99,100],"Rebound pain","Interscalene brachial plexus block","Single-shot nerve block","Continuous peripheral nerve block","Perineural catheter","Dexamethasone","Intravenous dexamethasone","Shoulder surgery","Rotator cuff repair","Regional anesthesia","Postoperative analgesia","Multimodal analgesia","Non-inferiority trial","Enhanced recovery after surgery","NOT_YET_RECRUITING","2026-07-09",{"date":104,"type":105},"2026-07-13","ACTUAL",{"date":107,"type":76},"2026-07-15",{"date":109,"type":76},"2027-07-15",{"name":5,"class":6},1]