[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100471936":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":45,"responsibleParty":65,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":26,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intravenous (IV) acetaminophen plus oral placebo","EXPERIMENTAL","In this group, the IV study drug will be IV acetaminophen and the oral study drug will be a placebo tablet.",[13],"Drug: Intravenous (IV) acetaminophen + oral placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Intravenous (IV) placebo plus oral acetaminophen","ACTIVE_COMPARATOR","In this group the IV study drug will be normal saline and the pill will be acetaminophen",[19],"Drug: Intravenous (IV) placebo plus oral acetaminophen",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Intravenous (IV) acetaminophen + oral placebo","Postoperatively patients will receive both a tablet and an IV solution every 6 hours for 48 hours, for a total of 8 doses. In this group, the IV study drug will be IV acetaminophen and the oral study drug will be a placebo tablet.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Postoperatively patients will receive both a tablet and an IV solution every 6 hours for 48 hours, for a total of 8 doses. In this group the IV study drug will be normal saline and the pill will be acetaminophen",[15],[31],{"name":32,"affiliation":5,"role":33},"Jean Wong, MD","PRINCIPAL_INVESTIGATOR",[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Laurentia Enesi","CONTACT","416-603-5800","3959","laurentia.enesi@uhn.ca",{"name":42,"role":37,"phone":38,"phoneExt":43,"email":44},"Aparna P Saripella","6137","aparna.saripella@uhn.ca",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Toronto Western Hospital (UHN)","RECRUITING","Toronto","Ontario","M5T 2S8","Canada","CA",{"type":55,"coordinates":56},"Point",[57,58],-79.39864,43.70643,{"lat":58,"lon":57},[61,63],{"name":62,"role":37,"phone":26,"phoneExt":26,"email":26},"Dr. Jean Wong, MD",{"name":64,"role":37,"phone":26,"phoneExt":26,"email":26},"Dr.Simone Schiavo, MD",{"type":33,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Jean Wong","Associate Professor, University of Toronto, Department of Anesthesiology and Pain Medicine","100471936","phase-4-intravenous-vs-oral-acetaminophen-in-postoperative-hip-fracture-adult-patients-100471936",false,"NCT05425355","Intravenous vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients","INTACT-HIP: INTravenous Acetaminophen vs. Oral Randomized Controlled Trial in HIP Fracture Patients - a Feasibility Trial","INTACT-HIP","Inclusion Criteria:\n\n* 60 years of age and older\n* Patients who were ambulating without human assistance before fracture, with any type of non-neoplastic hip fracture\n* Patients undergoing surgical treatment as an inpatient\n\nExclusion Criteria:\n\n* Patients with neoplastic hip fracture\n* Severe cognitive impairment (Montreal Cognitive Assessment (MoCA) \\\u003C10)\n* Pre-existing delirium\n* Known hypersensitivity or allergy to acetaminophen\n* Severe or chronic liver or kidney dysfunction\n* Planned postoperative ventilation\n* Swallowing issues and\u002For dysphagia\n* English language limitation\n* Weight \\\u003C50kg","ALL","60 Years",{"count":79,"type":80},42,"ESTIMATED","INTERVENTIONAL",[83],"PHASE4","The INTACT-HIP trial study will evaluate feasibility of conducting a randomized, double-blinded controlled trial comparing postoperative treatment with intravenous (IV) acetaminophen versus oral acetaminophen, in older adults undergoing hip fracture surgery.\n\nThe results of this feasibility trial will be used to inform designing a larger, multi-center, randomized controlled trial to assess the efficacy of IV acetaminophen compared to oral acetaminophen to reduce delirium and improve other clinical and patient-centered outcomes after hip fracture surgery. It will randomize 42 older adults to receive either oral or IV acetaminophen after hip fracture surgery.",[86,87],"Hip-fracture","Surgery",[89,90,91,92],"elderly","acetaminophen","oral vs intravenous","hip fracture surgery","2025-05-23",{"date":95,"type":96},"2025-05-30","ACTUAL",{"date":98,"type":96},"2023-01-23",{"date":100,"type":80},"2026-06-30",{"name":5,"class":6},1]