[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590367":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":31,"responsibleParty":50,"collaborators":52,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":18,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":78,"whyStopped":18,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Colgate Palmolive","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","ACTIVE_COMPARATOR","Regular fluoride toothpaste",[13],"Drug: Stannous Fluoride Toothpaste (SnF)",{"label":15,"type":16,"description":17,"interventionNames":18},"Test","NO_INTERVENTION","Stannous fluoride containing toothpaste",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DRUG","Stannous Fluoride Toothpaste (SnF)","stannous fluoride toothpaste",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Roger Arce, DDS, MS, PhD","CONTACT","713 486 4382","Roger.M.Arce@uth.tmc.edu",[32],{"facility":33,"status":18,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"UT Health School of Dentistry","Houston","Texas","77054","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-95.36327,29.76328,{"lat":43,"lon":42},[46],{"name":47,"role":28,"phone":48,"phoneExt":18,"email":49},"Roger Arce, Assoc Prof, Dept. of Periodontics & Oral Hygiene, DDS, MS, PhD","713-486-4382","rarcemunoz@uth.edu",{"type":51,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[53],{"name":54,"class":55},"The University of Texas Health Science Center, Houston","OTHER","100590367","phase-4-investigation-of-the-interplay-between-local-oral-inflammation-microbiota-and-systemic-immune-responses-100590367",false,"NCT06966492","Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.","ILIMSIR","Inclusion Criteria:\n\n1. Males and females, between 18-65 years of age;\n2. Availability for the duration of the study;\n3. ASA 1 Good general health (absence of any self-reported systemic disease or condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve\u002Fhip replacements, etc);\n4. Willingness to provide information related to their medical history;\n5. Minimum of 20 uncrowned permanent natural teeth (excluding third molars and crowns);\n6. Informed Consent Form signed.\n\nExclusion Criteria:\n\n1. Subjects with more that 2 sites with pocket depth of \\> 4 mm and those presenting purulent exudate, tooth mobility, and\u002For extensive loss of periodontal attachment or alveolar bone;\n2. Oral pathology or a history of allergy to testing products;\n3. Subject using anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication or daily analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; to be defined by the dental examiner;\n4. Subject participating in any other clinical study;\n5. Subject pregnant or breastfeeding;\n6. Subject allergic to oral care products and personal care consumer products\n7. Extended use of antibiotics or therapeutic mouthwash (eg: Chlorhexidine) any time during the three months prior to entry into the study;\n8. Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine)\n9. Current smokers (or users of tobacco and vaping products) and subjects with a history of alcohol or drug abuse;\n10. An existing medical condition which prohibits eating or drinking for periods up to 4 hours.\n11. Individuals with orthodontic bands or removable partial dentures.\n12. Dental prophylaxis in the previous 3 months prior to the baseline examination",true,"ALL","18 Years","65 Years",{"count":68,"type":69},20,"ESTIMATED","INTERVENTIONAL",[72],"PHASE4","This is a clinical research study designed to measure changes in inflammation and the oral microbiome during a phase of good oral hygiene and the absence of oral hygiene. The goal of the study is to investigate the interplay between local oral inflammation, microbiota and systemic immune responses.",[75],"Gingival Inflammation",[77],"induced gingivitis","NOT_YET_RECRUITING","2026-05-22",{"date":81,"type":82},"2026-05-26","ACTUAL",{"date":84,"type":69},"2026-06",{"date":86,"type":69},"2027-06",{"name":5,"class":6},1]