[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606567":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":57,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":25,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":25,"overallStatus":78,"whyStopped":25,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Thomas Jefferson University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Early ketamine","ACTIVE_COMPARATOR","Initiation of ketamine infusion simultaneously with midazolam infusion as the third-line anesthetic treatment",[13,14],"Drug: Ketamine","Drug: Midazolam",{"label":16,"type":10,"description":17,"interventionNames":18},"Late ketamine","Initiation of ketamine infusion only after midazolam infusion has been started",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Ketamine","Timing of ketamine initiation will differ between groups (early versus late ketamine)",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Midazolam","Midazolam infusion will be initiated at the same time in both groups",[9,16],[31],{"name":32,"affiliation":5,"role":33},"Syed O Shah, MD","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Elizabeth Fletman, DO","CONTACT","215-955-7000","elizabeth.fletman@jefferson.edu",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},"Syed 0 Shah, MD","Syed.Shah@Jefferson.edu",[44],{"facility":45,"status":25,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":25},"Thomas Jefferson University Hospital","Philadelphia","Pennsylvania","19107","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-75.16362,39.95238,{"lat":55,"lon":54},{"type":33,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Syed Omar Shah","Associate Professor, Neurology and Neurological Surgery","100606567","phase-4-ketamine-for-the-treatment-of-refractory-status-epilepticus-100606567",false,"NCT07177235","Ketamine for the Treatment of Refractory Status Epilepticus","Early Ketamine Plus Midazolam Versus Ketamine Plus Midazolam for the Treatment of Refractory Status Epilepticus","Inclusion Criteria:\n\n1. Adults 18 years of age or older\n2. Patients with refractory status epilepticus unresponsive to appropriately dosed first line agents administered intravenous or intraosseous and one second line agent\n\n   1. First line agents: lorazepam, midazolam, or diazepam\n   2. Second line agents: phenytoin (20 mg\u002Fkg), valproate (40 mg\u002Fkg), levetiracetam (60 mg\u002Fkg), lacosamide (400 mg)\n3. All etiologies of status epilepticus will be included\n\nExclusion Criteria:\n\n1. Exclusively psychogenic non epileptic seizures\n2. Pregnant individuals\n3. Incarcerated individuals\n4. Patients with hypersensitivity to ketamine or any component of the formulation\n5. Conditions in which an increase in blood pressure would be hazardous\n6. Focal motor status epilepticus\n7. Status epilepticus lasting \\> 24 hours prior to enrollment (SRSE)\n8. Patients with EEG in the ictal-interictal continuum (IIC)","ALL","18 Years",{"count":70,"type":71},50,"ESTIMATED","INTERVENTIONAL",[74],"PHASE4","This pilot feasibility study aims to examine how the timing of ketamine introduction as a third-line anti-seizure medication infusion relates to seizure cessation in patients with refractory status epilepticus (RSE).",[77],"Refractory Status Epilepticus","NOT_YET_RECRUITING","2025-09-09",{"date":81,"type":82},"2025-09-16","ACTUAL",{"date":84,"type":71},"2025-11",{"date":86,"type":71},"2028-07",{"name":5,"class":6},1]