[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100463036":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":34,"centralContacts":38,"locations":47,"responsibleParty":68,"collaborators":42,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":42,"eligibilityCriteria":75,"healthyVolunteers":72,"sex":76,"minAge":77,"maxAge":42,"enrollmentInfo":78,"targetDuration":42,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":50,"whyStopped":42,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Nebraska Methodist Health System","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nifedipine","ACTIVE_COMPARATOR","Patients randomized to Nifedipine will be started on Nifedipine XR 30mg BID. Escalation in therapy to be determined by primary provider. Maximum dose of Nifedipine is 120mg daily. All patients will be monitored for signs and symptoms of hypotension or medication side effect- severe HA, orthostasis, syncope.",[13],"Drug: NIFEdipine ER",{"label":15,"type":10,"description":16,"interventionNames":17},"Labetalol","Patients randomized to Labetalol will be started on 200mg TID. Escalation in therapy to be determined by primary provider. Maximum dose is 2400mg in a day. All patients will be monitored for signs and symptoms of hypotension or medication side effect- orthostasis, syncope, bradycardia.",[18],"Drug: Labetalol Oral Tablet",[20,28],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Labetalol Oral Tablet","See Labetalol arm.",[15],[26,27],"Normodyne","Trandate",{"type":21,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"NIFEdipine ER","See Nifedipine arm.",[9],[33],"Procardia XL",[35],{"name":36,"affiliation":5,"role":37},"Todd Lovgren, MD","PRINCIPAL_INVESTIGATOR",[39,44],{"name":36,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","4028151970",null,"todd.lovgren@nmhs.org",{"name":45,"role":40,"phone":41,"phoneExt":42,"email":46},"Joshua Dahlke, MD","joshua.dahlke@nmhs.org",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Nebraska Methodist Women's Hospital","RECRUITING","Omaha","Nebraska","68022","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-95.94043,41.25626,{"lat":60,"lon":59},[63,66],{"name":64,"role":40,"phone":65,"phoneExt":42,"email":43},"Todd Lovgren","402-815-1970",{"name":67,"role":40,"phone":41,"phoneExt":42,"email":46},"Josh Dahlke",{"type":69,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100463036","phase-4-labetalol-or-nifedipine-for-control-of-postpartum-hypertension-a-randomized-controlled-trial-100463036",false,"NCT05309460","Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial","Inclusion Criteria:\n\nAny patient admitted for delivery by cesarean or vaginal delivery at 24 weeks gestation or greater with hypertension(HTN). Hypertension will be defined during the study as either a systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg on two occasions at least 4 hours apart. This definition is consistent with the ACOG definition for pregnancy related HTN. Following enrollment, treatment will be escalated at discretion of primary provider with the goal of normotension.\n\nExclusion Criteria:\n\nHistory of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema\n\n* Contraindication to either Nifedipine or Labetalol\n* HR \\\u003C60 or \\>110\n* Native language other than English or Spanish","FEMALE","19 Years",{"count":79,"type":80},600,"ESTIMATED","INTERVENTIONAL",[83],"PHASE4","Randomized trial comparing risk of hospital readmission and hypertensive complications between patients managed on Labetalol compared to Nifedipine.",[86,87],"Postpartum Preeclampsia","Hypertension in Pregnancy",[9,15,89,90,91,92],"Postpartum","Hypertension","Preeclampsia","Pregnancy","2024-04-10",{"date":95,"type":96},"2024-04-12","ACTUAL",{"date":98,"type":96},"2022-06-20",{"date":100,"type":80},"2024-12-01",{"name":5,"class":6},1]