[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633677":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":26,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":84,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Bach Mai Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-dose norepinephrine infusion","EXPERIMENTAL","Participants receive a norepinephrine infusion at 0.05 micrograms\u002Fkg\u002Fmin starting 3 minutes before fentanyl during standardized induction of general anesthesia.",[13],"Drug: Norepinephrine (0.05 μg\u002Fkg\u002Fmin)",{"label":15,"type":16,"description":17,"interventionNames":18},"0.9% sodium chloride infusion","PLACEBO_COMPARATOR","Participants receive 0.9% sodium chloride with the same presentation, timing, and infusion settings as the intervention arm during standardized induction of general anesthesia.",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Norepinephrine (0.05 μg\u002Fkg\u002Fmin)","Norepinephrine prepared in a blinded syringe and infused continuously at 0.05 micrograms\u002Fkg\u002Fmin starting 3 minutes before fentanyl during induction of general anesthesia. Infusion is adjusted or temporarily stopped according to the protocol-defined hemodynamic safety algorithm.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Placebo: 0.9% Sodium Chloride prepared in a blinded syringe and administered with the same timing, presentation, and pump settings as the active study drug.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Thang Toan Nguyen, PhD","CONTACT","+084916874795","nguyentoanthang@hmu.edu.vn",[38],{"facility":39,"status":26,"city":40,"state":26,"zip":26,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Center for Anesthesia and Surgical Intensive Care, Bach Mai Hospital","Hanoi","Vietnam","VN",{"type":44,"coordinates":45},"Point",[46,47],105.84117,21.0245,{"lat":47,"lon":46},[50],{"name":51,"role":34,"phone":52,"phoneExt":26,"email":53},"Center for Anesthesia and Intensive Care, Bach Mai Hospital. Center for Anesthesia and Intensive Care, Bach Mai Hospital.","+084869587720","trungtamgaymehoisuc@bachmai.edu.vn",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Nguyen Toan Thang","Consultant Anesthesiologist, Director of Center for Anesthesia and Surgical ICU","100633677","phase-4-low-dose-norepinephrine-infusion-for-prevention-of-post-induction-hypotension-in-emergency-surgery-for-peritonitis-100633677",false,"NCT07529795","Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Emergency Surgery for Peritonitis","Protocolized Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Adults Undergoing Emergency Surgery for Secondary Peritonitis: A Randomized Double-blind Placebo-controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Secondary peritonitis requiring emergency surgery under general anesthesia with endotracheal intubation.\n* Planned induction with fentanyl, propofol, and rocuronium according to the study protocol.\n* Hemodynamically stabilized after initial resuscitation, with MAP at least 65 mmHg and no ongoing vasopressor infusion before induction.\n* ASA physical status I to III.\n* Written informed consent from the participant or a legally authorized representative.\n\nExclusion Criteria:\n\n* Allergy or contraindication to norepinephrine, propofol, fentanyl, or rocuronium.\n* Severe cardiovascular disease likely to confound hemodynamic assessment, including decompensated heart failure, acute coronary syndrome, severe arrhythmia, severe valvular disease, or major cardiomyopathy.\n* Ongoing vasopressor therapy before induction.\n* Shock before surgery, including hypovolemic, septic, or cardiogenic shock.\n* Severe hypertension before induction (systolic blood pressure \\>180 mmHg or mean arterial pressure \\>110 mmHg).\n* Severe peripheral vascular disease or clinically significant limb ischemia.\n* Current monoamine oxidase inhibitor use.\n* Pregnancy or breastfeeding.\n* Contraindication to arterial catheter placement.\n* Refusal of consent.","ALL","18 Years",{"count":68,"type":69},60,"ESTIMATED","INTERVENTIONAL",[72],"PHASE4","This study tests whether giving a low-dose norepinephrine infusion just before induction of anesthesia can reduce low blood pressure during emergency surgery for peritonitis. Adults with secondary peritonitis who are scheduled for emergency surgery and have stable blood pressure after initial resuscitation will be randomly assigned to receive either norepinephrine or placebo (normal saline) during induction of anesthesia. The main outcome is the cumulative time spent with mean arterial pressure (MAP) below 65 mmHg from the start of propofol administration to 10 minutes after endotracheal intubation. The study will also evaluate rescue vasopressor use, heart rate changes, drug-related adverse events, and selected early postoperative outcomes.",[75,76],"Secondary Peritonitis","Post-induction Hypotension",[78,79,80,81,82,83],"Emergency surgery","General anesthesia","Norepinephrine","Noradrenaline","Induction hypotension","Mean arterial pressure","NOT_YET_RECRUITING","2026-04-07",{"date":87,"type":88},"2026-04-14","ACTUAL",{"date":90,"type":69},"2026-04-01",{"date":92,"type":69},"2026-10",{"name":5,"class":6},1]