[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643557":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":39,"responsibleParty":54,"collaborators":37,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":37,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":37,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":82,"whyStopped":37,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Pakistan Institute of Medical Sciences","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low Dose Oral Isotretinoin","EXPERIMENTAL","Participants in this arm will receive a low-dose regimen of oral isotretinoin (e.g., 0.25mg\u002Fkg\u002Fday for the duration of the treatment period to evaluate its efficacy and safety in acne vulgaris.",[13],"Drug: Isotretinoin",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Dose Oral Isotretinoin","ACTIVE_COMPARATOR","participants in this arm will receive conventional dose of oral isotretinoin (e.g. 0.5 mg\u002Fkg\u002Fday) for the duration of the treatment period to evaluate its efficacy and safety in acne vulgaris.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Isotretinoin","Oral isotretinoin capsules administered daily to participants for the treatment of acne vulgaris. This study evaluates two distinct dosing regimens to compare their relative efficacy and safety: 1) Low-Dose Regimen: Participants receive a reduced daily dose (e.g. 0.25 mg\u002Fkg\u002Fday). 2) Conventional-Dose Regimen: Participants receive the standard weight-based dose (e.g., 0.5 mg\u002Fkg\u002Fday). Treatment duration, monitoring schedules, and dose adjustments follow protocol specifications.",[15,9],[26,27],"Accutane","Roaccutane",[29],{"name":30,"affiliation":31,"role":32},"Dr Nareeman Ur Rehman, MBBS, FCPS","Pakistan Institute of Medical Sciences (PIMS)","PRINCIPAL_INVESTIGATOR",[34],{"name":30,"role":35,"phone":36,"phoneExt":37,"email":38},"CONTACT","+923169560013",null,"naree.khan1@gmail.com",[40],{"facility":41,"status":37,"city":42,"state":37,"zip":37,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Pakistan Institute of Medical Sciences(PIMS)","Islamabad","Pakistan","PK",{"type":46,"coordinates":47},"Point",[48,49],73.04329,33.72148,{"lat":49,"lon":48},[52],{"name":53,"role":35,"phone":36,"phoneExt":37,"email":38},"Dr Nareeman Ur Rehman, MBBS,FCPS",{"type":32,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"Nareeman Ur Rehman","FCPS Resident, Department of Dermatology","100643557","phase-4-low-dose-versus-conventional-dose-oral-isotretinoin-for-acne-vulgaris-100643557",false,"NCT07639073","Low-Dose Versus Conventional-Dose Oral Isotretinoin for Acne Vulgaris","Comparing the Efficacy and Safety of Low-Dose Oral Isotretinoin Versus Conventional-Dose in the Treatment of Acne Vulgaris","Inclusion Criteria:\n\n* Both genders\n* Age 18-45 years\n* Patients who are clinically diagnosed with moderate to severe acne vulgaris as per criteria defined in operational definition.\n\nExclusion Criteria:\n\n* Patients who are pregnant or lactating\n* Patients with history of endocrine disorders such as PCOS etc. or having drug induced acne\n* Patients on corticosteroid treatment\n* Patients who have hypersensitivity to the isotretinoin\n* Patients who are taking any acne treatment\n* Patients with hyperlipidemia, chronic renal failure or liver failure","ALL","18 Years","45 Years",{"count":68,"type":69},164,"ESTIMATED","INTERVENTIONAL",[72],"PHASE4","Background and Purpose:\n\nAcne vulgaris is a common skin condition that can cause significant physical and emotional distress. Oral isotretinoin is a highly effective treatment for severe or persistent acne. While the standard (conventional) dose is effective, it is often associated with side effects like dry skin, chapped lips, and altered labs.\n\nThe purpose of this study is to compare a lower daily dose of oral isotretinoin against the conventional daily dose in individuals with acne vulgaris.\n\nWhat the Study Aims to Find Out:\n\nResearchers want to determine if a low-dose regimen can match the effectiveness (efficacy) of the conventional dose while reducing the frequency and severity of side effects (safety).\n\nStudy Design:\n\nParticipants will be randomly assigned to receive either the low-dose oral isotretinoin or the conventional-dose oral isotretinoin. Researchers will monitor and compare acne clearance rates, patient satisfaction, and any side effects experienced by the participants throughout the treatment period.",[75],"Acne Vulgaris",[22,26,77,78,79,80,81],"Acne Treatment","Dermatology","Low dose Isotretinoin","Conventional Dose Isotretinoin","Retinoids","NOT_YET_RECRUITING","2026-06-05",{"date":85,"type":86},"2026-06-10","ACTUAL",{"date":88,"type":69},"2026-07",{"date":90,"type":69},"2026-10",{"name":5,"class":6},1]