[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611903":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":57,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":26,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":26,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":81,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Wake Forest University Health Sciences","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard of Care","SHAM_COMPARATOR","standard treatment of cerebral vasospasm and sham injection of 10 mL preservative-free normal saline in luer-lock sterile syringe",[13],"Drug: Normal Saline",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of Care Plus Nicardipine","EXPERIMENTAL","standard treatment of cerebral vasospasm with prophylactic administration of intrathecal nicardipine",[19],"Drug: Nicardipine",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Normal Saline","10 mL preservative-free normal saline in luer-lock sterile syringe every 24 hours from randomization through day 14 post-bleed or lumbar drain removal, whichever occurs first.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Nicardipine","Nicardipine 4 mg will be diluted in preservative-free normal saline to 10 mL in luer-lock sterile syringe every 24 hours from randomization through day 14 post-bleed or lumbar drain removal, whichever occurs first.",[15],[32],{"name":33,"affiliation":34,"role":35},"Krishna Joshi, MD","Advocate Lutheran General Hospital","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Sajid Suriya, MD","CONTACT","847-723-2078","Sajid.suriya@aah.org",[43],{"facility":34,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Park Ridge","Illinois","60068","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-87.84062,42.01114,{"lat":53,"lon":52},[56],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},{"type":58,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100611903","phase-4-lumbar-drain-with-intrathecal-nicardipine-in-aneurysmal-subarachnoid-hemorrhage-100611903",false,"NCT07246629","Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage","Prophylactic Use of Intrathecal Calcium Channel Antagonist Through Lumbar Drain in Patients With Subarachnoid Hemorrhage Due to Aneurysmal Rupture","Inclusion Criteria:\n\n* Age ≥18 years\n* Aneurysmal subarachnoid hemorrhage with Hunt and Hess score 3 or less\n* Patient or legal authorized representative available to sign the informed consent form\n* Pre-morbid modified Rankin scale of 0 or 1.\n* Patients who have lumbar drain placed or planned for cerebrospinal fluid diversion per standard of care\n* Patients who are able to be randomized within 72 hours from arrival with aneurysmal subarachnoid hemorrhage or within 24 hours from lumbar drain placement\n\nExclusion Criteria:\n\n* Pregnant females\n* Subarachnoid hemorrhage (SAH) with hunt and hess scale of \\>3\n* SAH due to etiology other than aneurysmal rupture\n* Any contraindications in patients receiving calcium channel antagonists like hypersensitivity to dihydropyridines\n* Active central nerve infection (CNS) infection or high suspicion of CNS infection\n* Hemodynamic instability preventing the use of Nicardipine","ALL","18 Years",{"count":69,"type":70},214,"ESTIMATED","INTERVENTIONAL",[73],"PHASE4","The purpose of this study is to determine the effectiveness of prophylactic administration of intra-thecal nicardipine though lumbar cerebrospinal fluid drain in prevention of symptomatic vasospasm in patients with subarachnoid hemorrhage due to rupture of cerebral aneurysms.",[76],"Subarachnoid Hemorrhage",[78,79,80],"cerebral aneurysm","intrathecal nicardipine","vasospasm","NOT_YET_RECRUITING","2026-04-23",{"date":84,"type":85},"2026-04-24","ACTUAL",{"date":87,"type":70},"2026-06",{"date":89,"type":70},"2027-01",{"name":5,"class":6},1]