[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630294":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":48,"collaborators":18,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":18,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":18,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":33,"whyStopped":18,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"AdventHealth","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Methadone","EXPERIMENTAL","Patient will receive one perioperative dose of IV methadone prior to their surgical procedure in addition to standard of care medications.",[13],"Drug: Methadone",{"label":15,"type":16,"description":17,"interventionNames":18},"No medication","NO_INTERVENTION","Patient will receive only the standard of care medications for their procedure.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"DRUG","Subjects randomized to receive methadone will be given one dose of methadone 0.15mg\u002Fkg intravenously dosed based on ideal body weight administered by the anesthesia team prior to surgical incision",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Makenna Hemmerle","CONTACT","303-260-2951","makenna.hemmerle@adventhealth.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"AdventHealth Porter","RECRUITING","Denver","Colorado","80210","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-104.9847,39.73915,{"lat":43,"lon":42},[46],{"name":26,"role":27,"phone":47,"phoneExt":18,"email":29},"3032602951",{"type":49,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100630294","phase-4-methadone-in-the-management-of-post-operative-pain-in-total-knee-replacement-100630294",false,"NCT07485803","Methadone in the Management of Post-Operative Pain in Total Knee Replacement","A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent from\n2. Stated willingness to comply with all study procedures and availability to attend all required visits for the duration of the study.\n3. Age 21- 75\n4. Unilateral total knee arthroplasty at Colorado Joint Replacement\n5. All individuals will be screened for drug use (opioid use, illicit drug use) at their preoperative appointment\n6. For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation.\n\nExclusion Criteria:\n\n1. Narcotic use in the past 6 weeks\n2. Current or previous history of drug and alcohol abuse\n3. Tobacco use in the previous 90 days\n4. Treatment with another investigational drug\n5. Patients that cannot receive spinal anesthesia\n6. Patients that cannot receive the standardized multimodal pain medications (i.e. Tylenol, gabapentin and meloxicam)'\n7. Patients that are not able to go home after leaving the hospital and require a short-term rehabilitation facility\n8. Obstructive sleep apnea\n9. Morbid obesity (BMI \\>40)\n10. Patients with liver disease.\n11. Significant kidney disease - stage 3 CKD or greater\n12. Pregnant or nursing females\n13. Baseline QTc \\>480\n14. severe COPD (GOLD 3 or 4)\n15. home oxygen requirement","ALL","21 Years","75 Years",{"count":61,"type":62},192,"ESTIMATED","INTERVENTIONAL",[65],"PHASE4","The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.",[68],"Total Knee Arthroplasty",[70,71,72],"pain management","TKA","methadone","2026-06-16",{"date":75,"type":76},"2026-06-22","ACTUAL",{"date":78,"type":76},"2026-06-01",{"date":80,"type":62},"2028-06",{"name":5,"class":6},1]