[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638015":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":38,"centralContacts":42,"locations":51,"responsibleParty":69,"collaborators":33,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":33,"eligibilityCriteria":77,"healthyVolunteers":74,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":33,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":97,"whyStopped":33,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment Group","EXPERIMENTAL","Patients in the treatment group will receive a 4 mg oral 6-day methylprednisolone taper in addition to standard post-operative pain control. All patients will receive the surgeon's standard ACL postoperative multimodal pain regimen.",[13,14],"Drug: Methyl Prednisolone (MP)","Combination Product: Surgeon's Standard ACL Postoperative Regimen",{"label":16,"type":17,"description":18,"interventionNames":19},"Control Group","ACTIVE_COMPARATOR","Patients in the control group will receive standard post-operative pain control. All patients will receive the surgeon's standard ACL postoperative multimodal pain regimen.",[20,14],"Drug: Standard Post-Operative Pain Control",[22,29,34],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Methyl Prednisolone (MP)","Participants will receive 4mg oral tablet of methylprednisolone taper for 6 days after surgery.",[9],[28],"Corticosteroid",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Standard Post-Operative Pain Control","All patients will receive the surgeon's standard ACL postoperative multimodal pain regimen.",[16],null,{"type":35,"name":36,"description":31,"armGroupLabels":37,"otherNames":33},"COMBINATION_PRODUCT","Surgeon's Standard ACL Postoperative Regimen",[16,9],[39],{"name":40,"affiliation":5,"role":41},"Amit Momaya, MD","PRINCIPAL_INVESTIGATOR",[43,47],{"name":40,"role":44,"phone":45,"phoneExt":33,"email":46},"CONTACT","(205) 930-8339","amomaya@uabmc.edu",{"name":48,"role":44,"phone":49,"phoneExt":33,"email":50},"Crystal Taylor","205-807-4050","crystalmtaylor@uabmc.edu",[52],{"facility":5,"status":33,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Birmingham","Alabama","35294","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-86.80249,33.52066,{"lat":62,"lon":61},[65,66,68],{"name":40,"role":44,"phone":45,"phoneExt":33,"email":46},{"name":48,"role":44,"phone":67,"phoneExt":33,"email":50},"(205) 807-4050",{"name":40,"role":41,"phone":33,"phoneExt":33,"email":33},{"type":41,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Amit Momaya","Associate Professor","100638015","phase-4-methylprednisolone-addition-to-multimodal-pain-regimens-after-anterior-cruciate-ligament-reconstruction-100638015",false,"NCT07605923","Methylprednisolone Addition to Multimodal Pain Regimens After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* aged 14-65\n* undergoing ACL Reconstruction.\n\nExclusion Criteria:\n\n* contraindications to corticosteroids","ALL","14 Years","65 Years",{"count":82,"type":83},64,"ESTIMATED","INTERVENTIONAL",[86],"PHASE4","Patients who are being seen for ACL tears will be approached in the UAB Orthopedic Clinic. Included patients will be those aged 14-65 undergoing ACL Reconstruction. Excluded patients will be those with contraindications to corticosteroids. If the patient meets the criteria and agrees to participate, then the consent form will be signed, and the patient will be enrolled. Enrolled patients will be randomized to one of two groups. Patients in the treatment group will receive a 4 mg oral 6-day methylprednisolone taper in addition to standard post-operative pain control. Patients in the control group will receive standard post-operative pain control. All patients will receive the surgeon's standard ACL postoperative multimodal pain regimen. Endpoints will include narcotic consumption assessed daily and at one week post-op through a patient self-reported diary. The VAS pain score will be collected each day for the first week. Secondary endpoints will include range of motion and patient-reported outcomes, including IKDC, KOOS Jr, Tegner Activity Scale, ACL-RSI, and PROMIS Global collected at baseline, 2 weeks, 6 weeks and 3 months. All outcomes will be collected through PatientIQ.",[89],"ACL Reconstruction",[91,92,93,94,95,96],"ACL","Anterior Cruciate ligament reconstruction","postoperative pain","corticosteroid taper","methylprednisolone taper","multimodal pain protocol","NOT_YET_RECRUITING","2026-05-18",{"date":100,"type":101},"2026-05-26","ACTUAL",{"date":103,"type":83},"2026-09",{"date":105,"type":83},"2031-08",{"name":5,"class":6},1]