[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623085":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":26,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":67,"whyStopped":26,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":26},{"fullName":5,"class":6},"Jinnah Postgraduate Medical Centre","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Metronidazole 2% Gel","EXPERIMENTAL","Participants will apply 2% metronidazole gel as a thin layer twice daily (morning and night) for 12 weeks after gentle cleansing and drying.",[13],"Drug: Metronidazole Topical Gel 2%",{"label":15,"type":16,"description":17,"interventionNames":18},"Clindamycin 1% Gel","ACTIVE_COMPARATOR","Participants will apply 1% clindamycin gel as a thin layer twice daily (morning and night) for 12 weeks after gentle cleansing and drying.",[19],"Drug: Clindamycin Topical Gel 1%",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Metronidazole Topical Gel 2%","Topical metronidazole gel 2% applied as a thin layer to affected areas twice daily (morning and night) for 12 weeks after gentle cleansing and drying.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Clindamycin Topical Gel 1%","Topical clindamycin gel 1% applied as a thin layer to affected areas twice daily (morning and night) for 12 weeks after gentle cleansing and drying.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Rubab Murtaza, FCPS","CONTACT","0334 2341118","rubabumer96@gmail.com",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Rubab Murtaza","FCPS Resident","100623085","phase-4-metronidazole-2-gel-versus-clindamycin-1-gel-for-moderate-acne-vulgaris-100623085",false,"NCT07392047","Metronidazole 2% Gel Versus Clindamycin 1% Gel for Moderate Acne Vulgaris","Comparison Of The Efficacy Of 2% Metronidazole Gel Versus 1% Clindamycin Gel In The Treatment Of Moderate Acne Vulgaris","METROCLIN","Inclusion Criteria\n\nAdults aged 18-35 years of either sex.\n\nClinical diagnosis of moderate acne vulgaris, defined as a Modified Global Acne Grading System (mGAGS) score of 45-80.\n\nNot currently using any other anti-acne treatment (topical or systemic).\n\nExclusion Criteria\n\nPregnant or lactating women.\n\nSevere acne vulgaris, defined as an mGAGS score \\>80.\n\nKnown hypersensitivity\u002Fallergy to metronidazole or clindamycin (or any component of the study gels).\n\nAny other dermatologic condition affecting the face that may interfere with assessment of acne severity or treatment response.","ALL","18 Years","35 Years",{"count":53,"type":54},60,"ESTIMATED","INTERVENTIONAL",[57],"PHASE4","Acne vulgaris is a common inflammatory skin disorder. This randomized controlled trial (RCT) will compare the efficacy and safety of 2% metronidazole gel versus 1% clindamycin gel in adults with moderate acne vulgaris at Jinnah Postgraduate Medical Centre (JPMC), Karachi. Sixty eligible participants (18-35 years) will be enrolled using consecutive sampling and randomized in a 1:1 ratio using blocked randomization. Participants will apply the assigned gel as a thin layer twice daily for 12 weeks. Acne severity will be assessed using the Modified Global Acne Grading System (mGAGS) at baseline and at weeks 4, 8, and 12. The primary outcome is the proportion of participants achieving at least a 50% reduction from baseline in total mGAGS score at week 12. Local adverse effects (e.g., erythema, itching, irritation) will be recorded at each follow-up visit.",[60],"Acne Vulgaris",[62,63,64,65,66],"Moderate acne","Metronidazole gel","Clindamycin gel","Topical antibiotic","Modified Global Acne Grading System","NOT_YET_RECRUITING","2026-02-05",{"date":70,"type":71},"2026-02-06","ACTUAL",{"date":73,"type":54},"2026-02",{"date":75,"type":54},"2026-08",{"name":5,"class":6}]