[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621771":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":26,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":26,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":64,"overallStatus":70,"whyStopped":26,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":26},{"fullName":5,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Costoclavicular block with same previous successful volume","ACTIVE_COMPARATOR","Patients randomized to this group will receive the same volume that was successful in the previous recruitment.",[13],"Procedure: Ultrasound-guided double-injection costoclavicular nerve block with same previous volume",{"label":15,"type":16,"description":17,"interventionNames":18},"Costoclavicular block with lower volume","EXPERIMENTAL","This group will be randomized to receive a fixed lower volume than the previously successful block.",[19],"Procedure: Ultrasound-guided double-injection costoclavicular nerve block with lower volume",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Ultrasound-guided double-injection costoclavicular nerve block with same previous volume","ultrasound-guided double-injection costoclavicular nerve block with the same volume used in the previous successful block",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Ultrasound-guided double-injection costoclavicular nerve block with lower volume","Ultrasound-guided double-injection costoclavicular nerve block with lower volume than the previous successful block",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Julián Aliste, M.D.","CONTACT","+15149341934-43795","julian.aliste@mcgill.ca",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Julián Aliste","Associate Professor","100621771","phase-4-minimal-effective-volume-90-for-double-injection-costoclavicular-block-100621771",false,"NCT07374952","Minimal Effective Volume 90% for Double-injection Costoclavicular Block","Minimum Effective Volume of Lidocaine for Double-Injection Ultrasound-Guided Costoclavicular Block","Inclusion Criteria:\n\n* Age between 18 and 70 years\n* American Society of Anesthesiologists classification 1-3\n* Body mass index between 20 and 30\n\nExclusion Criteria:\n\n* Adults who are unable to give their own consent\n* Pre-existing neuropathy (assessed by history and physical examination)\n* Coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets≤ 100, International Normalized Ratio≥ 1.4 or partial prothrombin time ≥ 50)\n* Renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine≥ 100)\n* Hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases≥ 100)\n* Allergy to LA\n* Pregnancy\n* Prior surgery in the infraclavicular region\n* Chronic pain syndromes requiring opioid intake at home","ALL","18 Years","70 Years",{"count":52,"type":53},60,"ESTIMATED","INTERVENTIONAL",[56],"PHASE4","In 2020, a trial demonstrated that a 2-injection technique constitutes the optimal method for the costoclavicular block.\n\nThis study aims to determine the minimum amount of medication required to achieve a successful double-injection costoclavicular nerve.\n\nBlock dose assignment will be done using an up-and-down sequential method, called the Biased Coin Design (BCD).\n\nThe double-injection technique for US-guided costoclavicular block consists in depositing two thirds of the LA volume in the deep compartment (to anesthetize the posterior and medial cords), and one third of the injectate in the superficial compartment (to anesthetize the lateral cord).\n\nThe ED90 will be calculated using isotonic regression with a 95% confidence interval derived by bootstrapping.",[59,60,61,62,63],"Brachial Plexus Blocks","Lidocaine","Nerve Block","Dose Finding Study","Costoclavicular Block",[65,66,67,68,69],"costoclavicular block","double injection technique","dose finding","nerve block","lidocaine","NOT_YET_RECRUITING","2026-02-18",{"date":73,"type":74},"2026-02-20","ACTUAL",{"date":76,"type":53},"2026-02-01",{"date":78,"type":53},"2026-12-31",{"name":5,"class":6}]