[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557576":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":41,"locations":50,"responsibleParty":63,"collaborators":28,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":28,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":28,"maxAge":28,"enrollmentInfo":75,"targetDuration":28,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":87,"whyStopped":28,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Alexandria University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Modified TIPS Block","EXPERIMENTAL","Modified Triple Injection Peri-sartorial Block Patients will receive ultrasound guided single puncture triple injections through medial to lateral approach. LA will be injected at the distal FT lateral to the superficial femoral artery (FA), deep to adductor longus muscle (ALM), and at the supra-sartorial plane",[13,14,15],"Procedure: General Anesthesia","Procedure: TIPS block","Procedure: Mutimodal analgesia",{"label":17,"type":18,"description":19,"interventionNames":20},"TIPS Block","ACTIVE_COMPARATOR","Triple Injection Peri-sartorial Block Patients will receive distal FTB through conventional lateral to medial approach, in addition to a supra-sartorial plane injection",[13,21,15],"Procedure: Modified TIPS block",[23,29,33,37],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"PROCEDURE","General Anesthesia","All blocks will be performed after induction of general anaesthesia (GA). Upon arrival to the operating room (OR), a multichannel monitor will be attached to patients, followed by the administration of 2 mg midazolam IV after securing an IV cannula. Controlled GA via a laryngeal mask airway (LMA) will be done to all patients",[9,17],null,{"type":24,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"TIPS block","Patients will receive distal FTB through conventional lateral to medial approach, in addition to a supra-sartorial plane injection. Distal adductor canal block via another needle puncture.Ten mL of a mixture of 0.25 % bupivacaine and 8 mg dexamethasone will be injected in the suprasartorial plane and 20 mL will be injected at the distal adductor canal.Ten mL of the LA mixture will be injected 2 cm above the FT apex via ultrasound guided in-plane lateral to medial approach just lateral to the superficial femoral artery",[9],{"type":24,"name":34,"description":35,"armGroupLabels":36,"otherNames":28},"Modified TIPS block","Patients will receive ultrasound guided single puncture triple injections through medial to lateral approach. LA will be injected at the distal FT lateral to the superficial femoral artery (FA), deep to adductor longus muscle (ALM), and at the supra-sartorial plane.Both groups will receive a mixture of 0.25 % bupivacaine and 8 mg dexamethasone. Ten mL will be injected in the suprasartorial plane and 20 mL will be injected at the distal adductor canal.Ten mL of the LA anaesthetic mixture will be injected 2 cm above the FT apex via ultrasound guided in-plane medial to lateral approach just lateral to the superficial femoral artery. Then, the needle will be redirected just underneath the ALM and 10 mL of the LA mixture will be injected in the plane between the ALM and the adductor magnus muscle (AMM).Total volume of LA will be 50 mL.",[17],{"type":24,"name":38,"description":39,"armGroupLabels":40,"otherNames":28},"Mutimodal analgesia","Postoperatively, multimodal analgesia regimen will be continued in the form of paracetamol 1 g \u002F8 hours and ketorolac 30 mg \u002F8 hours intravenously for 24 hours. Intravenous morphine patient controlled analgesia will be started at the end of surgery at a concentration of 0.5 mg\u002Fml without a background infusion on a demand dose of 1 mg with a lockout interval of 10 minutes",[9,17],[42,48],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"moustafa Abdelaziz, MD","CONTACT","1222373407","+20","m.3abdelaziz@hotmail.com",{"name":49,"role":44,"phone":45,"phoneExt":46,"email":47},"moustafa Abdelaziz",[51],{"facility":52,"status":28,"city":53,"state":28,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":28},"Alexandria Faculty of Medicine","Alexandria","21651","Egypt","EG",{"type":58,"coordinates":59},"Point",[60,61],29.91582,31.20176,{"lat":61,"lon":60},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"PRINCIPAL_INVESTIGATOR","moustafa abdelaziz","Professor of Anaesthesia and Surgical Intensive Care","100557576","phase-4-modified-tips-block-for-total-knee-arthroplasty-100557576",false,"NCT06539910","Modified TIPS Block for Total Knee Arthroplasty","Modified Triple Injection Peri-Sartorius (TIPS) Block for Postoperative Analgesia After Total Knee Arthroplasty (TKA)","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-III\n\nExclusion Criteria:\n\n* BMI \\> 35 kg\u002Fm2 Pre-existing neurological deficit Any disability of the non-operated limb preventing fair mobilization Known contraindications to peripheral nerve block (coagulopathy or infection at the site of injection) Chronic opioid users\u002Fabusers","ALL",{"count":76,"type":77},90,"ESTIMATED","INTERVENTIONAL",[80],"PHASE4","The is carried out to compare triple injection peri-sartorial block to a modified block including an extra local anesthetic injection deep to the adductor longs muscle via a medial to lateral approach regarding the peri-operative analgesia following total knee arthroplasty (TKA)",[83,84],"Knee Arthropathy","Anesthesia, Local",[86],"Analgesia, arthroplasty, knee replacement, nerve block, peri-sartorial block, triple injection, visual analogue scale","NOT_YET_RECRUITING","2024-08-02",{"date":90,"type":91},"2024-08-06","ACTUAL",{"date":93,"type":77},"2024-08",{"date":95,"type":77},"2025-03",{"name":5,"class":6},1]