[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583480":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":31,"locations":36,"responsibleParty":40,"collaborators":42,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":36,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":69,"whyStopped":36,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":36},{"fullName":5,"class":6},"Uppsala University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Propofol","ACTIVE_COMPARATOR","Propofol Maintenance Anesthesia",[13],"Drug: Anesthesia Maintenance Agent",{"label":15,"type":10,"description":16,"interventionNames":17},"Sevoflurane","Sevoflurane Maintenance Anesthesia",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Anesthesia Maintenance Agent","Difference in renal blood flow (RBF) between Propofol and Sevoflurane groups. Quantified by specific Multiparametric MRI metrics (e.g., (Renal blood flow by phase contrast imaging) (regional perfusion by Arterial Spin labeling (ASL) and global and regional oxygenation by Blood oxygen dependent signal (BOLD))",[9,15],[25,15,9],"Anesthesia",[27],{"name":28,"affiliation":29,"role":30},"Robert Frithiof, Professor","Istitution of Surgical Sciences, Anesthesiology and Intensive Care","STUDY_CHAIR",[32,38],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Arash Emami, PhD student","CONTACT","+46763222722",null,"arash.emami@uu.se",{"name":28,"role":34,"phone":36,"phoneExt":36,"email":39},"robert.frithiof@uu.se",{"type":41,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR",[43],{"name":44,"class":6},"Uppsala University Hospital","100583480","phase-4-mr-evaluation-of-renal-function-in-anesthetized-pediatric-patients-100583480",false,"NCT06876870","MR-Evaluation of Renal Function in Anesthetized Pediatric Patients","MERAPED","Inclusion Criteria:\n\n* Pediatric Patients (1 month -14 years of age)\n* Indicated for MRI with anesthesia\n* ASA (American Society of Anesthesiologists) physical status I-III\n\nExclusion Criteria:\n\n* Known renal impairment or chronic kidney disease\n* Severe cardiac or pulmonary disease\n* Allergy to either Propofol or Sevoflurane\n* Contraindications to Magnetic Resonance Imaging\n* Contraindications to either Propofol or Sevoflurane\n* Declined participation or declined consent from patients, parents or guardians\n* Ongoing acute kidney injury","ALL","1 Month","14 Years",{"count":56,"type":57},50,"ESTIMATED","INTERVENTIONAL",[60],"PHASE4","The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys.\n\nPediatric patients who are planned to undergo an MRI scan with generalized anesthesia will be randomized to either IV anesthesia with propofol or inhalation anesthesia with sevoflurane. Both of these anesthetic methods are commonly used for anesthesia on an everyday basis.\n\nIn addition to the clinically indicated MRI, Multiparametric MRI will be performed to visualize the effect of the anesthetic agent on renal blood flow, perfusion and oxygenation.",[63,25,64,65],"Renal Blood Flow","MRI","Renal Oxygenation",[67,25,68,64],"Renal Blood flow","Pediatric","NOT_YET_RECRUITING","2025-03-20",{"date":72,"type":73},"2025-03-25","ACTUAL",{"date":75,"type":57},"2025-10-01",{"date":77,"type":57},"2027-06-20",{"name":5,"class":6}]