[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530389":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":36,"locations":46,"responsibleParty":67,"collaborators":25,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":25,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":49,"whyStopped":25,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Murdoch Childrens Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intravenous (IV) Morphine Patient controlled analgesia (PCA)","ACTIVE_COMPARATOR","Morphine PCA IV 20mcg\u002Fkg bolus to a maximum of 1mg with a 5-minute lockout- as per current RCH Children's Pain Management Service (CPMS) dosing and use.",[13],"Drug: Morphine",{"label":15,"type":10,"description":16,"interventionNames":17},"IV Oxycodone PCA","Oxycodone PCA IV 20mcg\u002Fkg bolus to a maximum of 1mg with a 5-minute lockout- as per current RCH Children's Pain Management Service (CPMS) dosing and use.",[18],"Drug: Oxycodone",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Morphine","Intravenous (IV) delivery via Patient Controlled Analgesia device (PCA) 20mcg\u002Fkg bolus to a maximum of 1mg with a 5-minute lockout",[9],null,{"type":21,"name":27,"description":23,"armGroupLabels":28,"otherNames":29},"Oxycodone",[15],[30,31],"Oxycodone Juno","Oxycodone HCI Medsurge",[33],{"name":34,"affiliation":5,"role":35},"Sue May Koh","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":25,"email":41},"Justine Adams","CONTACT","03 8341 6200","justine.adams@mcri.edu.au",{"name":43,"role":39,"phone":44,"phoneExt":25,"email":45},"Suzette Sheppard","03 9345 4901","Suzette.sheppard@mcri.edu.au",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"The Royal Children's Hospital","RECRUITING","Melbourne","Victoria","3052","Australia","AU",{"type":56,"coordinates":57},"Point",[58,59],144.96332,-37.814,{"lat":59,"lon":58},[62,63],{"name":38,"role":39,"phone":40,"phoneExt":25,"email":41},{"name":64,"role":39,"phone":65,"phoneExt":25,"email":66},"Su May Koh","03 9345 5233","Su.Koh@rch.org.au",{"type":68,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100530389","phase-4-nausea-and-vomiting-in-postoperative-paediatric-patients-with-patient-controlled-analgesia-pca-morphine-vs-oxycodone-100530389",false,"NCT06186141","Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone","A Comparison of Nausea and Vomiting in Postoperative Paediatric Patients With Patient-controlled Analgesia (PCA): Morphine vs Oxycodone (POPCORN)","POPCORN","Inclusion Criteria:\n\n* Postoperative patients who are appropriate for a PCA including those aged 6 and above and up to age 18 years.\n* Those deemed appropriate for either morphine or oxycodone by their treating anaesthetist.\n* American Society of Anaesthesiologists (ASA) score 1-3 inclusive\n* Those whose parents or legal guardians have provided informed consent on the patient's behalf.\n\nExclusion Criteria:\n\n* Any patients with an allergy, hypersensitivity, or contraindication to morphine or oxycodone.\n* Patients in the age group with significant intellectual disability or physical incapacity rendering them incapable of using the PCA device\n* ASA score 4 or above\n* Inability or unwillingness of parent or legal guardian to provide informed consent for the study.","ALL","6 Years","18 Years",{"count":81,"type":82},690,"ESTIMATED","INTERVENTIONAL",[85],"PHASE4","POPCORN trial will compare the side effects and effectiveness of Morphine versus Oxycodone medication when prescribed for use as patient controlled analgesia (PCA) for pain relief for paediatric patients after-surgery. This trial is embedded into routine patient care using the hospital electronic medical record (EMR). Participants will be randomly assigned to either medication after they enrol in the study.\n\nThe main questions the POPCORN trial aims to answer are:\n\n* 1\\. Is there a difference in the usage of medication to treat nausea and vomiting for those who received oxycodone PCA versus morphine PCA for post-surgery pain relief?\n* 2\\. Is there a difference in side effects or pain relief needed between the two groups?\n\nStudy activities are as follows:\n\n* Participants enrolled to study during their pre-operative consultation\n* Participants are randomly assigned to morphine or oxycodone\n* No further study-specific activities expected from participant after enrolment and randomisation\n* Participant receives routine medical care as planned\n* Clinicians record assessments as per routine care in electronic medical record (EMR)\n* EMR data are extracted as trial data",[88],"Patient-Controlled Analgesia",[90,91,92,93,94,95],"Post-operative Pain","Paediatric","Patient-controlled analgesia","Paediatric analgesia","Post-operative","Embedded clinical trials","2025-08-20",{"date":98,"type":99},"2025-08-27","ACTUAL",{"date":101,"type":99},"2024-03-13",{"date":103,"type":82},"2027-03-19",{"name":5,"class":6},1]