[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623043":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":26,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":26,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":64,"whyStopped":26,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":70,"leadSponsor":72,"locationsCount":26},{"fullName":5,"class":6},"Shenzhen Hospital of Southern Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nitroglycerin Ointment Group","EXPERIMENTAL","Participants in this arm will receive standard perioperative management following endoscopic rubber band ligation for internal hemorrhoids, plus topical nitroglycerin ointment. The ointment will be applied to the intrarectal wound area starting after the procedure, three times daily, with approximately 1-1.5 cm of ointment per application, for a total duration of 2 weeks. Rescue analgesia with oral loxoprofen sodium will be permitted according to the predefined protocol when clinically indicated.",[13],"Drug: Nitroglycerin Ointment",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Ointment Group","PLACEBO_COMPARATOR","Participants in this arm will receive standard perioperative management following endoscopic rubber band ligation for internal hemorrhoids, plus a placebo ointment identical in appearance to the study drug. The placebo ointment will be applied to the intrarectal wound area starting after the procedure, three times daily, with approximately 1-1.5 cm of ointment per application, for a total duration of 2 weeks. Rescue analgesia with oral loxoprofen sodium will be permitted according to the predefined protocol when clinically indicated.",[19],"Drug: Placebo Ointment",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Nitroglycerin Ointment","Nitroglycerin ointment will be applied locally to the intrarectal wound area after endoscopic rubber band ligation for internal hemorrhoids. Treatment will begin immediately after the procedure. Participants will apply approximately 1-1.5 cm of ointment three times daily for a total duration of 2 weeks, in addition to standard perioperative management. Rescue analgesia with oral loxoprofen sodium will be permitted according to the predefined protocol when clinically indicated.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo Ointment","A placebo ointment identical in appearance and packaging to the study drug will be applied locally to the intrarectal wound area after endoscopic rubber band ligation for internal hemorrhoids. Treatment will begin immediately after the procedure. Participants will apply approximately 1-1.5 cm of ointment three times daily for a total duration of 2 weeks, in addition to standard perioperative management. Rescue analgesia with oral loxoprofen sodium will be permitted according to the predefined protocol when clinically indicated.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Zhu Ying","CONTACT","+86-13384662039","zhuying1@smu.edu.cn",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Ying Zhu","Principal Investigator, Department of Internal Medicine","100623043","phase-4-nitroglycerin-ointment-for-pain-relief-after-endoscopic-hemorrhoid-band-ligation-100623043",false,"NCT07391501","Nitroglycerin Ointment for Pain Relief After Endoscopic Hemorrhoid Band Ligation","A Randomized, Double-Blind, Placebo-Controlled Study of Nitroglycerin Ointment for Postoperative Pain Relief After Endoscopic Rubber Band Ligation of Internal Hemorrhoids","Inclusion Criteria:\n\n* Age: 18 to 75 years, male or female\n* Diagnosis\u002Findication: Internal hemorrhoids grade I, II, or III scheduled for endoscopic rubber band ligation\n* Consent: Able and willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Compliance\u002Fassessment: Unable to understand study endpoints or complete study records\u002Fforms\n* Concomitant medications: Current use of oral nitrates or calcium channel blockers\n* Allergy: Known allergy to lactulose oral solution, nitroglycerin ointment, or other study-related medications\n* Pregnancy\u002Flactation: Pregnant or breastfeeding women\n* Procedure tolerance: Unable to tolerate hemorrhoid band ligation, colonoscopy, or bowel preparation\n* Severe comorbidities: Severe cardiac, respiratory, neurologic, or psychiatric disorders\n* Legal capacity: Lacking legal capacity for civil conduct or lacking insight\u002Fjudgment to provide valid consent","ALL","18 Years","75 Years",{"count":52,"type":53},68,"ESTIMATED","INTERVENTIONAL",[56],"PHASE4","This study is designed to evaluate whether nitroglycerin ointment can reduce pain after endoscopic rubber band ligation for internal hemorrhoids. Endoscopic rubber band ligation is a commonly used, minimally invasive treatment for internal hemorrhoids, but postoperative anal pain is a frequent and sometimes severe complication that can affect daily activities and recovery.\n\nParticipants undergoing endoscopic rubber band ligation will be randomly assigned to receive either nitroglycerin ointment or a placebo ointment applied locally after the procedure. Both participants and investigators will be blinded to the treatment assignment. All participants will receive the same standard perioperative care, and rescue pain medication will be provided when necessary.\n\nThe primary goal of the study is to compare the proportion of patients who require rescue pain medication within 72 hours after the procedure between the two groups. Secondary outcomes include pain intensity at multiple time points, time to complete pain relief, postoperative complications, treatment-related adverse events, and overall treatment effectiveness at 30 days. The results of this study may help identify a safe and effective option for improving pain control after endoscopic treatment of internal hemorrhoids.",[59,60],"Internal Hemorrhoids","Postoperative Pain After Endoscopic Rubber Band Ligation",[59,62,63,23],"Endoscopic Rubber Band Ligation","Postoperative Pain","NOT_YET_RECRUITING","2026-02-01",{"date":67,"type":68},"2026-02-05","ACTUAL",{"date":65,"type":53},{"date":71,"type":53},"2028-11-30",{"name":39,"class":6}]